Active ingredient: Tramadol Hydrochloride

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Tramadol Hydrochloride uses


Pharmacological action

Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Tramadol Hydrochloride is a racemate and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.

Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Tramadol Hydrochloride has also an antitussive effect.

Pharmacokinetics

After oral administration Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). Cmax in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.

Plasma protein binding is 20%. Tramadol Hydrochloride is widely distributed in tissues. Vd after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.

Tramadol Hydrochloride metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.

This medicine excreted by the kidneys - 90% and through the intestines - 10%.

Why is Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals prescribed?

Moderate and severe pain of various origins. Conducting painful diagnostic or therapeutic procedures.

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Dosage and administration

A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.

For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.

The duration of treatment is determined individually.

The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.

Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals side effects, adverse reactions

CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin.

Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.

Digestive system: dry mouth, nausea, vomiting.

Metabolism: increased sweating.

Musculoskeletal system: miosis.

Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals contraindications

  • acute intoxication with alcohol and drugs, providing a depressing effect on the CNS
  • children up to age 1 year
  • hypersensitivity to Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals

    Using during pregnancy and breastfeeding

    During pregnancy patients should avoid prolonged use of Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.

    If necessary using in lactation should be aware that Tramadol Hydrochloride in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.

    Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.

    Patients need to avoid combination with MAO inhibitors.

    During the period of treatment with Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals you should avoid to take alcohol.

    Tramadol Hydrochloride in the form of long-acting formulations should not be used in children under the age of 14 years.

    During the period of Tramadol Hydrochloride using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.

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    Special instructions

    With caution Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals should be used in convulsions of central genesis of drug dependence, confusion, patients with impaired renal function and liver, as well as increased sensitivity to other opioid receptor agonists.

    Tramadol Hydrochloride should not be used beyond the period justified from a therapeutic point of view.

    Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals drug interactions

    Simultaneous administration of Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals with:

  • drugs providing a depressing effect on the CNS or with ethanol may increase the CNS depressant effects of Tramadol Hydrochloride;
  • MAO inhibitors are likely development of serotonin syndrome;
  • serotonin reuptake inhibitors, tricyclic antidepressants, antipsychotics, other means of reducing the threshold of convulsive readiness, increases the risk of seizures;
  • warfarin and phenprocoumon increase anticoagulant effect;
  • carbamazepine reduced the concentration of Tramadol Hydrochloride in plasma and its analgesic effect;
  • paroxetine describes cases of serotonin syndrome, seizures;
  • sertraline, fluoxetine describes cases of serotonin syndrome;
  • opioid analgesics is likely to reduce the analgesic action. Prolonged use of opioid analgesics or barbiturates stimulates the development of cross-tolerance;
  • naloxone activates respiration, eliminating analgesia after opioid analgesics.

    Tramadol Hydrochloride Karnataka Antibiotics & Pharmaceuticals in case of emergency / overdose

    Symptoms: respiratory depression, until apnea, seizures, Pupillary, anuria, coma.

    Treatment: IV injection of naloxone (a specific antagonist), gastric lavage, maintenance of vital functions.

    Tramadol Hydrochloride available forms, composition, doses:


    Indications and Usages:

    ATC codes:


    ICD-10 codes:


    Tramadol Hydrochloride destination | category:


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    Drugs with same active ingredients (Pharmaceutical companies):


    References

    1. Dailymed."TRAMADOL HYDROCHLORIDE TABLET [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "Tramadol". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "Tramadol". http://www.drugbank.ca/drugs/DB0019... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Tramadol Hydrochloride?

    Depending on the reaction of the Tramadol Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tramadol Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Tramadol Hydrochloride addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Tramadol Hydrochloride, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Tramadol Hydrochloride consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    One visitor reported side effects

    Did you get side effects while taking the Tramadol Hydrochloride drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Tramadol Hydrochloride medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    It has side effects1
    100.0%

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Tramadol Hydrochloride is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Expensive1
    100.0%

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Tramadol Hydrochloride drug as prescribed by the doctor?

    Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Tramadol Hydrochloride is mentioned below.
    Visitors%
    4 times in a day1
    100.0%

    Two visitors reported doses

    What is the dose of Tramadol Hydrochloride drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    51-100mg1
    50.0%
    1-5mg1
    50.0%

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Visitor reported age

    No survey data has been collected yet

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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