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Tramadol uses

Pharmacological action

Tramadol Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Tramadol is a racemate and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.

Tramadol Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Tramadol has also an antitussive effect.


After oral administration Tramadol Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). Cmax in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.

Plasma protein binding is 20%. Tramadol is widely distributed in tissues. Vd after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.

Tramadol metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.

This medicine excreted by the kidneys - 90% and through the intestines - 10%.

Why is Tramadol Karnataka Antibiotics & Pharmaceuticals prescribed?

Moderate and severe pain of various origins. Conducting painful diagnostic or therapeutic procedures.

Dosage and administration

A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.

For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.

The duration of treatment is determined individually.

The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.


Tramadol Karnataka Antibiotics & Pharmaceuticals side effects, adverse reactions

CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin.

Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.

Digestive system: dry mouth, nausea, vomiting.

Metabolism: increased sweating.

Musculoskeletal system: miosis.

Tramadol Karnataka Antibiotics & Pharmaceuticals contraindications

  • acute intoxication with alcohol and drugs, providing a depressing effect on the CNS
  • children up to age 1 year
  • hypersensitivity to Tramadol Karnataka Antibiotics & Pharmaceuticals

    Using during pregnancy and breastfeeding

    During pregnancy patients should avoid prolonged use of Tramadol Karnataka Antibiotics & Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.

    If necessary using in lactation should be aware that Tramadol in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.

    Tramadol Karnataka Antibiotics & Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.

    Patients need to avoid combination with MAO inhibitors.

    During the period of treatment with Tramadol Karnataka Antibiotics & Pharmaceuticals you should avoid to take alcohol.

    Tramadol in the form of long-acting formulations should not be used in children under the age of 14 years.

    During the period of Tramadol using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.

    Special instructions

    With caution Tramadol Karnataka Antibiotics & Pharmaceuticals should be used in convulsions of central genesis of drug dependence, confusion, patients with impaired renal function and liver, as well as increased sensitivity to other opioid receptor agonists.

    Tramadol should not be used beyond the period justified from a therapeutic point of view.

    Tramadol Karnataka Antibiotics & Pharmaceuticals drug interactions

    Simultaneous administration of Tramadol Karnataka Antibiotics & Pharmaceuticals with:

  • drugs providing a depressing effect on the CNS or with ethanol may increase the CNS depressant effects of Tramadol;
  • MAO inhibitors are likely development of serotonin syndrome;
  • serotonin reuptake inhibitors, tricyclic antidepressants, antipsychotics, other means of reducing the threshold of convulsive readiness, increases the risk of seizures;
  • warfarin and phenprocoumon increase anticoagulant effect;
  • carbamazepine reduced the concentration of Tramadol in plasma and its analgesic effect;
  • paroxetine describes cases of serotonin syndrome, seizures;
  • sertraline, fluoxetine describes cases of serotonin syndrome;
  • opioid analgesics is likely to reduce the analgesic action. Prolonged use of opioid analgesics or barbiturates stimulates the development of cross-tolerance;
  • naloxone activates respiration, eliminating analgesia after opioid analgesics.

    Tramadol Karnataka Antibiotics & Pharmaceuticals in case of emergency / overdose

    Symptoms: respiratory depression, until apnea, seizures, Pupillary, anuria, coma.

    Treatment: IV injection of naloxone (a specific antagonist), gastric lavage, maintenance of vital functions.


    Tramadol pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

    Tramadol available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Capsules, Extended Release; Oral; Tramadol Hydrochloride 100 mg
    Capsules, Extended Release; Oral; Tramadol Hydrochloride 200 mg
    Capsules, Extended Release; Oral; Tramadol Hydrochloride 300 mg
    Capsules; Oral; Tramadol Hydrochloride
    Capsules; Oral; Tramadol Hydrochloride 100 mg
    Capsules; Oral; Tramadol Hydrochloride 50 mg
    Drops; Oral; Tramadol Hydrochloride
    Drops; Oral; Tramadol Hydrochloride 100 mg / ml
    Injectable; Injection; Tramadol Hydrochloride 100 mg / ml
    Injectable; Injection; Tramadol Hydrochloride 50 mg / ml
    Solution; Oral; Tramadol Hydrochloride
    Suppositories; Rectal; Tramadol Hydrochloride
    Suppositories; Rectal; Tramadol Hydrochloride 100 mg
    Tablets, Effervescent; Oral; Tramadol Hydrochloride 50 mg
    Tablets, Extended Release; Oral; Tramadol Hydrochloride 100 mg
    Tablets, Extended Release; Oral; Tramadol Hydrochloride 200 mg
    Tablets, Extended Release; Oral; Tramadol Hydrochloride 300 mg
    Tablets, Film-Coated; Oral; Tramadol Hydrochloride 50 mg
    Tablets, Orally Disintegrating; Oral; Tramadol Hydrochloride 50 mg
    Tablets, Retard; Oral; Tramadol Hydrochloride 100 mg
    Tablets, Retard; Oral; Tramadol Hydrochloride 150 mg
    Tablets, Retard; Oral; Tramadol Hydrochloride 200 mg
    Tablets; Oral; Tramadol Hydrochloride
    Tablets; Oral; Tramadol Hydrochloride 100 mg
    Tablets; Oral; Tramadol Hydrochloride 50 mg
    TraMADol HCl 100 mg 24 Hour tablet3.78 USD
    TraMADol HCl 200 mg 24 Hour tablet6.25 USD
    Tramadol hcl 50 mg tablet0.7 USD
    Tramadol hcl powder29.08 USD
    Tramadol-Acetaminophen 37.5-325 mg tablet1.07 USD
    Ultram 50 mg tablet1.99 USD
    Ultram ER 100 mg 24 Hour tablet4.62 USD
    Ultram ER 200 mg 24 Hour tablet7.64 USD
    Ultram ER 300 mg 24 Hour tablet10.66 USD
    Ultram er 100 mg tablet4.44 USD
    Ultram er 200 mg tablet7.35 USD
    Ultram er 300 mg tablet10.25 USD


    Tramadol destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

    Tramadol Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

    Tramadol pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



    2. "Tramadol". (accessed August 28, 2018).
    3. "Tramadol". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Tramadol?

    Depending on the reaction of the Tramadol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tramadol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Tramadol addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Tramadol, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Tramadol consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the website users shows the following figures about several people who felt the medicine Tramadol is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.

    Visitor reported frequency of use

    No survey data has been collected yet

    Sixteen visitors reported doses

    What is the dose of Tramadol drug you are taking?
    According to the survey conducted among website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

    Five visitors reported time for results

    What is the time duration Tramadol drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say website users needed 1 day to notice the result from using Tramadol drug. The time needed to show improvement in health condition after using the medicine Tramadol need not be same for all the users. It varies based on other factors.
    1 day2
    3 days1
    > 3 month1
    1 month1

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Tramadol drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    After food1

    Six visitors reported age

    > 604

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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