Vitamin C (vitamin c) is essential for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones, and the capillary walls. Vitamin C (Ascorbic Acid) participates in redox reactions, the metabolism of tyrosine, converting folic acid into folinic acid, metabolism of carbohydrates, the synthesis of lipids and proteins, iron metabolism, processes of cellular respiration. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, enhances the body's resistance to infections; enhances iron absorption, contributing to its sequestration in reduced form. Vitamin C (Ascorbic Acid) has antioxidant properties.
With intravaginal application of Vitamin C (Ascorbic Acid) lowers the vaginal pH, inhibiting the growth of bacteria and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).
After oral administration Vitamin C (Ascorbic Acid) is completely absorbed from the gastrointestinal tract. Widely distributed in body tissues.
The concentration of Vitamin C (Ascorbic Acid) in blood plasma in normal amounts to approximately 10-20 mg / ml.
The concentration of Vitamin C (Ascorbic Acid) in white blood cells and platelets is higher than in erythrocytes and plasma. When deficient state of concentration in leucocytes is reduced later and more slowly and is regarded as the best criterion for evaluating the deficit than the concentration in plasma.
Plasma protein binding is about 25%.
Vitamin C (Ascorbic Acid) is reversibly oxidized to form dehydroascorbic acid, is metabolized with the formation of ascorbate-2-sulphate which is inactive and oxalic acid which is excreted in the urine.
Vitamin C (Ascorbic Acid) taken in excessive quantities is rapidly excreted unchanged in urine, it usually happens when exceeding a daily dose is 200 mg.
Why is Vitamin C prescribed?
For systemic use of Vitamin C (Ascorbic Acid) RiteMED Phils: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.
For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.
Dosage and administration
This medication administered orally, IM, IV, intravaginally.
For the prevention of deficiency conditions Vitamin C dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.
For intravaginal used Vitamin C (Ascorbic Acid) drugs in appropriate dosage forms.
Vitamin C (Ascorbic Acid) side effects, adverse reactions
CNS: headache, fatigue, insomnia.
Digestive system: stomach cramps, nausea and vomiting.
Allergic reaction: describes a few cases of skin reactions and manifestations of the respiratory system.
Urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones of calcium oxalate.
Local reactions: with intravaginal application - a burning or itching in the vagina, increased mucous discharge, redness, swelling of the vulva. Other: sensation of heat.
Vitamin C contraindications
Increased sensitivity to Vitamin C (Ascorbic Acid).
Using during pregnancy and breastfeeding
The minimum daily requirement of Vitamin C in the II and III trimester of pregnancy is about 60 mg.
Vitamin C (Ascorbic Acid) crosses the placental barrier. It should be borne in mind that the fetus can adapt to high doses of Vitamin C (Ascorbic Acid), which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. Therefore, during pregnancy should not to take Vitamin C (Ascorbic Acid) in high doses, except in cases where the expected benefit outweighs the potential risk.
The minimum daily requirement during lactation (breastfeeding) is 80 mg. Vitamin C (Ascorbic Acid) is excreted in breast milk. A mother's diet that contains adequate amounts of Vitamin C (Ascorbic Acid), is sufficient to prevent deficiency in an infant. It is unknown whether dangerous to the child's mother use of Vitamin C (Ascorbic Acid) in high doses. Theoretically it is possible. Therefore, it is recommended not to exceed the maximum daily nursing mother needs to Vitamin C (Ascorbic Acid), except when the expected benefit outweighs the potential risk.
Vitamin C (Ascorbic Acid) is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because Vitamin C (Ascorbic Acid) increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia.
Patients with high content body iron should apply Vitamin C (Ascorbic Acid) in minimal doses.
Vitamin C (Ascorbic Acid) is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase.
The use of Vitamin C (Ascorbic Acid) in high doses can cause exacerbation of sickle cell anemia.
Data on the diabetogenic action of Vitamin C (Ascorbic Acid) are contradictory. However, prolonged use of Vitamin C (Ascorbic Acid) should periodically monitor your blood glucose levels.
It is believed that the use of Vitamin C (Ascorbic Acid) in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in Vitamin C (Ascorbic Acid) in patients with advanced cancer.
Absorption of Vitamin C (Ascorbic Acid) decreased while use of fresh fruit or vegetable juices, alkaline drinking.
Vitamin C drug interactions
In an application with barbiturates, primidone increases the excretion of Vitamin C (Ascorbic Acid) in the urine.
With the simultaneous use of oral contraceptives reduces the concentration of Vitamin C (Ascorbic Acid) in blood plasma.
In an application of Vitamin C (Ascorbic Acid) with iron preparations Vitamin C (Ascorbic Acid), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.
Vitamin C (Ascorbic Acid) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.
With the simultaneous use of aspirin reduces the absorption of Vitamin C (Ascorbic Acid) by about a third.
Vitamin C (Ascorbic Acid) in an application with warfarin may decrease effects of warfarin.
With the simultaneous application of Vitamin C (Ascorbic Acid) increases the excretion of iron in patients receiving deferoxamine. In the application of Vitamin C (Ascorbic Acid) at a dose of 500 mg / day possibly left ventricular dysfunction.
In an application with tetracycline is increased excretion of Vitamin C (Ascorbic Acid) in the urine.
There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Vitamin C (Ascorbic Acid) 500 mg 2 times / day.
May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.
Vitamin C in case of emergency / overdose
Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day).
Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy).
When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.
Vitamin C (Ascorbic Acid) available forms, composition, doses:
Can i drive or operate heavy machine after consuming Vitamin C (Ascorbic Acid)?
Depending on the reaction of the Vitamin C (Ascorbic Acid) after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Vitamin C (Ascorbic Acid) not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Vitamin C (Ascorbic Acid) addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
sDrugs.com conducted a study on Vitamin C (Ascorbic Acid), and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Vitamin C (Ascorbic Acid) consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
One visitor reported useful
How is the drug Vitamin C (Ascorbic Acid) useful in reducing or relieving the symptoms? How useful is it? According to the survey conducted by the website sDrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
One visitor reported frequency of use
How often in a day do you take the medicine? Are you taking the Vitamin C (Ascorbic Acid) drug as prescribed by the doctor? Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Vitamin C (Ascorbic Acid) is mentioned below.
Once in a day
One visitor reported time for results
What is the time duration Vitamin C (Ascorbic Acid) drug must be taken for it to be effective or for it to reduce the symptoms? Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sDrugs.com website users needed 5 days to notice the result from using Vitamin C (Ascorbic Acid) drug. The time needed to show improvement in health condition after using the medicine Vitamin C (Ascorbic Acid) need not be same for all the users. It varies based on other factors.
Two visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Vitamin C (Ascorbic Acid) drug, before food or after food? Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
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The information was verified by Dr. Arunabha Ray, MD Pharmacology