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DRUGS & SUPPLEMENTS
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Acido Ascorbico
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Acido Ascorbico uses
Pharmacological action
Acido Ascorbico is essential for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones, and the capillary walls. Acido Ascorbico participates in redox reactions, the metabolism of tyrosine, converting folic acid into folinic acid, metabolism of carbohydrates, the synthesis of lipids and proteins, iron metabolism, processes of cellular respiration. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, enhances the body's resistance to infections; enhances iron absorption, contributing to its sequestration in reduced form. Acido Ascorbico has antioxidant properties.
With intravaginal application of Acido Ascorbico lowers the vaginal pH, inhibiting the growth of bacteria and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).
Pharmacokinetics
After oral administration Acido Ascorbico is completely absorbed from the gastrointestinal tract. Widely distributed in body tissues.
The concentration of Acido Ascorbico in blood plasma in normal amounts to approximately 10-20 mg / ml.
The concentration of Acido Ascorbico in white blood cells and platelets is higher than in erythrocytes and plasma. When deficient state of concentration in leucocytes is reduced later and more slowly and is regarded as the best criterion for evaluating the deficit than the concentration in plasma.
Plasma protein binding is about 25%.
Acido Ascorbico is reversibly oxidized to form dehydroascorbic acid, is metabolized with the formation of ascorbate-2-sulphate which is inactive and oxalic acid which is excreted in the urine.
Acido Ascorbico taken in excessive quantities is rapidly excreted unchanged in urine, it usually happens when exceeding a daily dose is 200 mg.
Why is Acido Ascorbico prescribed?
For systemic use of Acido Ascorbico RiteMED Phils: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.
For intravaginal use: chronic or recurrent vaginitis caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.
Dosage and administration
This medication administered orally, IM, IV, intravaginally.
For the prevention of deficiency conditions Acido Ascorbico dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.
For intravaginal used Acido Ascorbico drugs in appropriate dosage forms.
Acido Ascorbico side effects, adverse reactions
CNS: headache, fatigue, insomnia.
Digestive system: stomach cramps, nausea and vomiting.
Allergic reaction: describes a few cases of skin reactions and manifestations of the respiratory system.
Urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones of calcium oxalate.
Local reactions: with intravaginal application - a burning or itching in the vagina, increased mucous discharge, redness, swelling of the vulva. Other: sensation of heat.
Acido Ascorbico contraindications
Increased sensitivity to Acido Ascorbico.
Using during pregnancy and breastfeeding
The minimum daily requirement of Acido Ascorbico in the II and III trimester of pregnancy is about 60 mg.
Acido Ascorbico crosses the placental barrier. It should be borne in mind that the fetus can adapt to high doses of Acido Ascorbico, which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. Therefore, during pregnancy should not to take Acido Ascorbico in high doses, except in cases where the expected benefit outweighs the potential risk.
The minimum daily requirement during lactation is 80 mg. Acido Ascorbico is excreted in breast milk. A mother's diet that contains adequate amounts of Acido Ascorbico, is sufficient to prevent deficiency in an infant. It is unknown whether dangerous to the child's mother use of Acido Ascorbico in high doses. Theoretically it is possible. Therefore, it is recommended not to exceed the maximum daily nursing mother needs to Acido Ascorbico, except when the expected benefit outweighs the potential risk.
Special instructions
Acido Ascorbico is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because Acido Ascorbico increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia.
Patients with high content body iron should apply Acido Ascorbico in minimal doses.
Acido Ascorbico is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase.
The use of Acido Ascorbico in high doses can cause exacerbation of sickle cell anemia.
Data on the diabetogenic action of Acido Ascorbico are contradictory. However, prolonged use of Acido Ascorbico should periodically monitor your blood glucose levels.
It is believed that the use of Acido Ascorbico in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in Acido Ascorbico in patients with advanced cancer.
Absorption of Acido Ascorbico decreased while use of fresh fruit or vegetable juices, alkaline drinking.
Acido Ascorbico drug interactions
In an application with barbiturates, primidone increases the excretion of Acido Ascorbico in the urine.
With the simultaneous use of oral contraceptives reduces the concentration of Acido Ascorbico in blood plasma.
In an application of Acido Ascorbico with iron preparations Acido Ascorbico, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.
Acido Ascorbico in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.
With the simultaneous use of aspirin reduces the absorption of Acido Ascorbico by about a third.
Acido Ascorbico in an application with warfarin may decrease effects of warfarin.
With the simultaneous application of Acido Ascorbico increases the excretion of iron in patients receiving deferoxamine. In the application of Acido Ascorbico at a dose of 500 mg / day possibly left ventricular dysfunction.
In an application with tetracycline is increased excretion of Acido Ascorbico in the urine.
There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Acido Ascorbico 500 mg 2 times / day.
May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.
Acido Ascorbico in case of emergency / overdose
Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day).
Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy).
When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.
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Frequently asked Questions
Can i drive or operate heavy machine after consuming Acido Ascorbico?Depending on the reaction of the Acido Ascorbico after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Acido Ascorbico not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Acido Ascorbico addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Acido Ascorbico, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Acido Ascorbico consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
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The information was verified by Dr. Rachana Salvi, MD Pharmacology