Active ingredient: Nifedipine

What is the dose of the medication you are taking?
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Nifedipine uses


Pharmacological action

Nifedipine is aSelective calcium channel blocker class II, a derivative of dihydropyridine. This medication inhibits the entry of calcium into cardiomyocytes and vascular smooth muscle cells. Nifedipine has antianginal and hypotensive action. This drug lowers the tone of vascular smooth muscle. Nifedipine dilates coronary and peripheral arteries, lowers blood pressure and slightly - myocardial contractility, reduces afterload and myocardial oxygen demand. This medicine improves coronary blood flow. Nifedipine practically does not possess antiarrhythmic activity, it does not inhibit the conductance of myocardium.

Pharmacokinetics

When administered orally Nifedipine is rapidly absorbed from the gastrointestinal tract. This drug undergoes metabolism in the "first pass" through the liver. The protein binding is 92-98%. Nifedipine metabolized in the liver to form inactive metabolites. T1/2 is about 2 hours. This medication excreted mainly by the kidneys as metabolites in trace amounts in unchanged form; 20% is excreted from the gut in the form of metabolites.

Why is Nifedipine prescribed?

Prevention of angina attacks, in some cases - relief of angina attacks, hypertension, hypertensive crises, Raynaud's disease.

Dosage and administration

The dosing regimen is individual. For oral administration the initial dose is 10 mg 3-4 times / day. If necessary the dose gradually increased up to 20 mg 3-4 times / day. In some cases (variant angina, severe hypertension) for a short time the dose can be increased to 30 mg 3-4 times / day. For relief of hypertensive crisis, as well as angina attack this drug can be used sublingually in 10-20 mg (rarely 30 mg).

To IN relieve an angina attack or hypertensive crisis - 5 mg for 4-8 hours.

Intracoronary dose for relief of acute coronary artery spasm injected bolus is 100-200 mcg. With stenosis of major coronary vessels starting dose is 50-100 micrograms.

The maximum daily dose: oral - 120 mg, IV - 30 mg.

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Nifedipine side effects, adverse reactions

Cardiovascular: flushing of the skin, a feeling of warmth, tachycardia, hypotension, peripheral edema; rarely - bradycardia, ventricular tachycardia, asystole, increased angina attacks.

Digestive system: nausea, heartburn, diarrhea, rarely - liver function impairment and in rare cases - gingival hyperplasia. The chronic administration in high doses may cause dyspeptic symptoms, elevated liver enzymes, intrahepatic cholestasis.

CNS and peripheral nervous system: headache. The chronic administration in high doses may cause paresthesia, muscle pain, tremors, visual disturbances light, and sleep disorders.

Hemopoietic system: in rare cases - leukopenia, thrombocytopenia.

Urinary system: an increase in daily diuresis. The chronic administration in high doses may cause renal dysfunction.

Endocrine system: in rare cases - gynecomastia.

Allergic reactions: skin rash.

Local reactions: for IV injections might burning at the injection site.

Within 1 min after intracoronary administration it can be a result in the negative inotropic action of Nifedipine, the increase in heart rate, hypotension, and these symptoms gradually disappear within 5-15 minutes.

Nifedipine contraindications

Hypotension, collapse, cardiogenic shock, severe heart failure, severe aortic stenosis; increased sensitivity to Nifedipine.

Using during pregnancy and breastfeeding

Adequate and well-controlled studies safety of Nifedipine in pregnancy was not been conducted. The use of Nifedipine in pregnancy is not recommended.

Because Nifedipine is excreted in breast milk, you should avoid its use during lactation or to stop breastfeeding during the treatment with this medication.

In experimental studies it have been revealed embryotoxic, fetotoxic and teratogenic effects of Nifedipine.

Category effects on the fetus by FDA - C.

Special instructions

In patients with stable angina at the beginning of treatment paradoxical enhancement anginalnyh pain may occurs, with pronounced coronary sclerosis and unstable angina - the aggravation of myocardial ischemia. Not recommended to use short-acting drugs for long-term treatment of angina or hypertension, because it is possible the development of unpredictable changes in BP and reflex angina.

Nifedipine drug interactions

Nitrates, beta-blockers, diuretics, tricyclic antidepressants, fentanyl, alcohol increase the hypotensive effect of Nifedipine Quality Pharmaceutical Laboratory. This medication increases the activity of theophylline reduces the renal clearance of digoxin. Nifedipine increases the side effects of vincristine ; increases the bioavailability of cephalosporins (cefixime). Cimetidine and ranitidine increase the level of this drug in plasma. Diltiazem slows the metabolism (requires dose reduction of Nifedipine) of Nifedipine Quality Pharmaceutical Laboratory. This medicine is incompatible with rifampicin (accelerates biotransformation and does not allow to create effective concentration). Grapefruit juice (large quantity) increases its bioavailability.

Nifedipine in case of emergency / overdose

Symptoms: sudden bradycardia, bradyarrhythmia, hypotension, in severe cases - collapse, slowing conduction. When you receive a large number of retard-tablets symptoms of intoxication occur no earlier than 3-4 h and may additionally be expressed in loss of consciousness up to coma, cardiogenic shock, convulsions, hyperglycemia, metabolic acidosis, hypoxia.

Treatment: gastric lavage, activated charcoal method, injections of norepinephrine, calcium chloride or calcium gluconate in a solution of atropine (IV). Hemodialysis is ineffective.

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Nifedipine available forms, composition, doses:

Price
Adalat CC 30 mg 24 Hour tablet1.81 USD
Adalat CC 60 mg 24 Hour tablet2.99 USD
Adalat CC 90 mg 24 Hour tablet3.5 USD
Adalat Xl 20 mg Extended-Release Tablet1.34 USD
Adalat Xl 30 mg Extended-Release Tablet1.34 USD
Adalat Xl 60 mg Extended-Release Tablet1.41 USD
Adalat cc 30 mg tablet1.61 USD
Adalat cc 60 mg tablet2.87 USD
Adalat cc 90 mg tablet3.37 USD
Afeditab cr 30 mg tablet1.26 USD
Afeditab cr 60 mg tablet2.24 USD
Apo-Nifed 10 mg Capsule0.51 USD
Apo-Nifed 5 mg Capsule0.39 USD
Capsules; Oral; Nifedipine 10 mg
Capsules; Oral; Nifedipine 20 mg
Capsules; Oral; Nifedipine 5 mg
Coral calcium 1000 mg caplet0.09 USD
Coral calcium plus 1500 mg caplet0.13 USD
Dragee; Oral; Nifedipine 10 mg
Mylan-Nifedipine Extended Release 60 mg Extended-Release Tablet1.18 USD
NIFEDIPINE 10 MG CAPSULE
NIFEDIPINE 5MG CAPSULE
NIFEdipine 10 mg capsule0.97 USD
NIFEdipine 20 mg capsule1.74 USD
NIFEdipine CR Osmotic 30 mg 24 Hour tablet1.35 USD
NIFEdipine CR Osmotic 60 mg 24 Hour tablet2.38 USD
NIFEdipine CR Osmotic 90 mg 24 Hour tablet2.66 USD
Nifediac cc 30 mg tablet1.15 USD
Nifediac cc 60 mg tablet2.17 USD
Nifediac cc 90 mg tablet2.57 USD
Nifedipine er 30 mg tablet1.32 USD
Nifedipine er 60 mg tablet2.29 USD
Nifedipine er 90 mg tablet2.56 USD
Nifedipine powder15.3 USD
Procardia 10 mg capsule1.17 USD
Procardia XL 30 mg 24 Hour tablet2.39 USD
Procardia XL 60 mg 24 Hour tablet4.13 USD
Procardia XL 90 mg 24 Hour tablet4.77 USD
Procardia xl 30 mg tablet2.56 USD
Procardia xl 60 mg tablet4.43 USD
Procardia xl 90 mg tablet4.58 USD
Tablets, Extended Release; Oral; Nifedipine 10 mg
Tablets, Extended Release; Oral; Nifedipine 20 mg
Tablets, Extended Release; Oral; Nifedipine 30 mg
Tablets, Extended Release; Oral; Nifedipine 60 mg
Tablets, Extended Release; Oral; Nifedipine 90 mg
Tablets, Film-Coated; Oral; Nifedipine 10 mg
Tablets, Prolonged Release; Oral; Nifedipine 10 mg
Tablets, Prolonged Release; Oral; Nifedipine 20 mg
Tablets, Prolonged Release; Oral; Nifedipine 30 mg
Tablets; Oral; Nifedipine 10 mg
Tablets; Oral; Nifedipine 5 mg

Indications and Usages:

ATC codes:


ICD-10 codes:


Nifedipine destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."PROCARDIA XL (NIFEDIPINE) TABLET, FILM COATED, EXTENDED RELEASE [PFIZER LABORATORIES DIV PFIZER INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."NIFEDIPINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "nifedipine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Nifedipine?

Depending on the reaction of the Nifedipine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Nifedipine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Nifedipine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Nifedipine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Nifedipine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Visitor reported frequency of use

No survey data has been collected yet

Two visitors reported doses

What is the dose of Nifedipine drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
201-500mg1
50.0%
6-10mg1
50.0%

Two visitors reported time for results

What is the time duration Nifedipine drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 5 days to notice the result from using Nifedipine drug. The time needed to show improvement in health condition after using the medicine Nifedipine need not be same for all the users. It varies based on other factors.
Visitors%
5 days1
50.0%
> 3 month1
50.0%

Visitor reported administration

No survey data has been collected yet

One visitor reported age

Visitors%
> 601
100.0%

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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