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DRUGS & SUPPLEMENTS
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Active ingredient: Diphenhydramine Hydrochloride
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Diphenhydramine Hydrochloride uses
Pharmacological action
Diphenhydramine Hydrochloride Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.
When Diphenhydramine Hydrochloride Xepa-Soul Pattinson administered orally Diphenhydramine Hydrochloride has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.
When applied externally it has antiallergic effect.
Pharmacokinetics
Diphenhydramine Hydrochloride Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min. Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).
Why is Diphenhydramine Hydrochloride Xepa-Soul Pattinson prescribed?
Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.
Dosage and administration
Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of Diphenhydramine Hydrochloride Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.
Diphenhydramine Hydrochloride Xepa-Soul Pattinson side effects, adverse reactions
Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.
Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.
Diphenhydramine Hydrochloride Xepa-Soul Pattinson contraindications
Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to Diphenhydramine Hydrochloride.
Using during pregnancy and breastfeeding
During pregnancy and lactation, Diphenhydramine Hydrochloride used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.
Special instructions
With careful use Diphenhydramine Hydrochloride during pregnancy and lactation.
During the period of treatment with Diphenhydramine Hydrochloride Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.
Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.
Precautionary measures
Diphenhydramine Hydrochloride Xepa-Soul Pattinson is not recommended for SC injection. Since Diphenhydramine Hydrochloride has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history, increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with Diphenhydramine Hydrochloride should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.
Diphenhydramine Hydrochloride Xepa-Soul Pattinson drug interactions
When Diphenhydramine Hydrochloride Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.
With simultaneous use of Diphenhydramine Hydrochloride Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of Diphenhydramine Hydrochloride.
The antagonistic interaction observed with a joint appointment with psychostimulants.
Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.
Diphenhydramine Hydrochloride Xepa-Soul Pattinson in case of emergency / overdose
Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.
Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.
Diphenhydramine Hydrochloride available forms, composition, doses:
Indications and Usages:
ATC codes:
ICD-10 codes:
Diphenhydramine Hydrochloride destination | category:
Drugs with same active ingredients (Pharmaceutical companies):
References
- Dailymed."VICKS ZZZQUIL LIQUID AND LIQUICAPS COMBO (DIPHENHYDRAMINE HYDROCHLORIDE) KIT [THE PROCTER & GAMBLE MANUFACTURING COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "diphenhydramine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "diphenhydramine". http://www.drugbank.ca/drugs/DB0107... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Diphenhydramine Hydrochloride?Depending on the reaction of the Diphenhydramine Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Diphenhydramine Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Diphenhydramine Hydrochloride addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Diphenhydramine Hydrochloride, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Diphenhydramine Hydrochloride consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Diphenhydramine Hydrochloride useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Visitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Diphenhydramine Hydrochloride is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Expensive | 1 | 100.0% | |
One visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Diphenhydramine Hydrochloride drug as prescribed by the doctor?
Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Diphenhydramine Hydrochloride is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 4 times in a day | 1 | 100.0% | |
Visitor reported doses
No survey data has been collected yetVisitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology