Citalopram

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Citalopram uses


Pharmacological action

Citalopram is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Citalopram lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.

Pharmacokinetics

After oral administration Cmax of Citalopram in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Citalopram are linear. Css in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Citalopram is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T1/2 is 1.5 days.

Citalopram is excreted by the kidneys and the bowel.

Why is Citalopram prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Citalopram is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Citalopram is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Citalopram side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.

Citalopram contraindications

Hypersensitivity to Citalopram; simultaneous taking MAO inhibitors.

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Using during pregnancy and breastfeeding

Safety of Citalopram during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Citalopram on reproduction and prenatal development of the fetus.

Special instructions

In patients with liver failure Citalopram should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Citalopram Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Citalopram it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Citalopram may cause a more pronounced bradycardia.

The efficacy and safety of Citalopram in children has not been established.

Citalopram should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Citalopram in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Citalopram drug interactions

Simultaneous administration of Citalopram with:

  • MAO inhibitors may develop a hypertensive crisis ;
  • cimetidine may moderate increase in Css of Citalopram in plasmaThe inhibitory effect on CYP2D6 isoenzyme is expressed very poorly, so the interaction with drugs that affect the metabolism of this enzyme is minimal. But we can not exclude the decrease in the concentration of Citalopram in plasma by increasing its metabolism by carbamazepine induction of liver enzymes in their simultaneous application.

    The effects of sumatriptan and other serotonergic medications can be amplified by Citalopram in their simultaneous application.

    Citalopram in case of emergency / overdose

    Symptoms: dizziness, sweating, nausea, vomiting, tremor, somnolence, sinus tachycardia. In more rare cases - amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, ECG changes.

    Treatment: gastric lavage and use of activated carbon. Maintaining an airway to ensure adequate ventilation and oxygenation. It is recommended careful observation and monitoring of vital functions. Due to the large volume of distribution of Citalopram is unlikely efficiency such measures as forced diuresis, dialysis, hemoperfusion and exchange transfusion. There is no specific antidote.

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    Citalopram pharmaceutical active ingredients containing related brand and generic drugs:


    Citalopram available forms, composition, doses:

    Price
    Apo-Citalopram 20 mg Tablet0.82 USD
    Apo-Citalopram 40 mg Tablet0.82 USD
    CITALOPRAM 10MG TABLET
    CITALOPRAM 20MG TABLET
    CITALOPRAM 40MG TABLET
    Celexa 10 mg tablet3.57 USD
    Celexa 20 mg tablet1.47 USD
    Celexa 40 mg tablet1.47 USD
    Citalopram 20 mg Tablet0.82 USD
    Citalopram 40 mg Tablet0.82 USD
    Citalopram Hydrobromide 10 mg tablet2.68 USD
    Citalopram Hydrobromide 10 mg/5ml Solution 240ml Bottle122.28 USD
    Citalopram Hydrobromide 20 mg tablet2.8 USD
    Citalopram Hydrobromide 40 mg tablet2.89 USD
    Citalopram hbr 10 mg tablet2.33 USD
    Citalopram hbr 20 mg tablet2.43 USD
    Citalopram hbr 40 mg tablet2.53 USD
    Citalopram-Odan 20 mg Tablet0.82 USD
    Citalopram-Odan 40 mg Tablet0.82 USD
    Co Citalopram 20 mg Tablet0.82 USD
    Co Citalopram 40 mg Tablet0.82 USD
    Ctp 30 30 mg Tablet0.99 USD
    Jamp-Citalopram 20 mg Tablet0.82 USD
    Jamp-Citalopram 40 mg Tablet0.82 USD
    Mint-Citalopram 20 mg Tablet0.82 USD
    Mint-Citalopram 40 mg Tablet0.82 USD
    Mylan-Citalopram 20 mg Tablet0.82 USD
    Mylan-Citalopram 40 mg Tablet0.82 USD
    Ng Citalopram 20 mg Tablet0.82 USD
    Ng Citalopram 40 mg Tablet0.82 USD
    Novo-Citalopram 20 mg Tablet0.82 USD
    Novo-Citalopram 40 mg Tablet0.82 USD
    Phl-Citalopram 20 mg Tablet0.82 USD
    Phl-Citalopram 40 mg Tablet0.82 USD
    Pms-Citalopram 10 mg Tablet0.47 USD
    Pms-Citalopram 20 mg Tablet0.82 USD
    Pms-Citalopram 40 mg Tablet0.82 USD
    Ran-Citalo 20 mg Tablet0.82 USD
    Ran-Citalo 40 mg Tablet0.82 USD
    Ran-Citalopram 20 mg Tablet0.82 USD
    Ran-Citalopram 40 mg Tablet0.82 USD
    Ratio-Citalopram 20 mg Tablet0.82 USD
    Ratio-Citalopram 40 mg Tablet0.82 USD
    Sandoz Citalopram 20 mg Tablet0.82 USD
    Sandoz Citalopram 40 mg Tablet0.82 USD
    Tablets, Film-Coated; Oral; Citalopram 10 mg
    Tablets, Film-Coated; Oral; Citalopram 20 mg
    Tablets, Film-Coated; Oral; Citalopram 40 mg
    Tablets, Film-Coated; Oral; Citalopram 60 mg

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    Citalopram destination | category:


    Citalopram Anatomical Therapeutic Chemical codes:


    Citalopram pharmaceutical companies:


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    References

    1. Dailymed."CITALOPRAM TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "citalopram". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "citalopram". http://www.drugbank.ca/drugs/DB0021... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Citalopram?

    Depending on the reaction of the Citalopram after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Citalopram not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Citalopram addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Citalopram, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Citalopram consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    One visitor reported side effects

    Did you get side effects while taking the Citalopram drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Citalopram medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    No side effects1
    100.0%

    Visitor reported price estimates

    No survey data has been collected yet

    Two visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Citalopram drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Citalopram is mentioned below.
    Visitors%
    Once in a day2
    100.0%

    Two visitors reported doses

    What is the dose of Citalopram drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    1-5mg1
    50.0%
    6-10mg1
    50.0%

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Visitor reported age

    No survey data has been collected yet

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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