ZCin

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ZCin uses


Pharmacological action

ZCin is a macrolide antibiotic of azalides group. ZCin inhibits RNA-dependent protein synthesis of sensitive microorganisms.

It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. ; gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Pharmacokinetics

ZCin rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of ZCin. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the ZCin is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.

Why is ZCin prescribed?

Infectious-inflammatory diseases caused by microorganisms susceptible to ZCin, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease.

Dosage and administration

Dosage of ZCin is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

ZCin side effects, adverse reactions

Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.

Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Dermatological reactions: rarely - photosensitization.

CNS: dizziness, headache, rarely - drowsiness, weakness.

Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.

Cardiovascular system: rarely - chest pain.

Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.

Other: rarely - hyperglycemia, arthralgia.

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Contraindications

Hypersensitivity to ZCin and other macrolide antibiotics.

Using during pregnancy and breastfeeding

ZCin crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary to use ZCin in the lactation period should solve the issue of termination of breastfeeding.

Special instructions

ZCin not recommended for use in patients with compromised liver function.

ZCin uses with careful with impaired renal function.

This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.

ZCin drug interactions

Simultaneous administration of ZCin with these drugs and medications may has followed effects:

  • ergot alkaloids: can not been exclude the risk of ergotism;
  • warfarin: there was described amplification effect of warfarin;
  • digoxin or digitoxin: may be significantly increase the concentration of cardiac glycosides in plasma and risk of glycoside intoxication;
  • disopyramide: described a case of ventricular fibrillation;
  • lovastatin: there was describes some cases of rhabdomyolysis;
  • ZCin with rifabutin increases risk of neutropenia and leukopenia;
  • cyclosporine: disturbed metabolism of cyclosporine which increases the risk of adverse and toxic reactions caused by cyclosporine

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    ZCin pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    ZCin available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    ZCin destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    ZCin Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    ZCin pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."AZITHROMYCIN TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "azithromycin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming ZCin?

    Depending on the reaction of the ZCin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider ZCin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is ZCin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on ZCin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of ZCin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug ZCin useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Not useful1
    100.0%

    One visitor reported side effects

    Did you get side effects while taking the ZCin drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking ZCin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    It has side effects1
    100.0%

    Visitor reported price estimates

    No survey data has been collected yet

    Visitor reported frequency of use

    No survey data has been collected yet

    Visitor reported doses

    No survey data has been collected yet

    Visitor reported time for results

    No survey data has been collected yet

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking ZCin drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    With a meal1
    100.0%

    Visitor reported age

    No survey data has been collected yet

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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