Active ingredient: Azithromycin

Rating: 5 - 3 review(s)
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Azithromycin uses


Pharmacological action

azithromycin is a macrolide antibiotic of azalides group. azithromycin inhibits RNA-dependent protein synthesis of sensitive microorganisms.

It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. ; gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Pharmacokinetics

azithromycin rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of azithromycin. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the azithromycin is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.

Why is azithromycin prescribed?

Infectious-inflammatory diseases caused by microorganisms susceptible to azithromycin, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease.

Dosage and administration

Dosage of azithromycin is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

azithromycin side effects, adverse reactions

Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.

Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Dermatological reactions: rarely - photosensitization.

CNS: dizziness, headache, rarely - drowsiness, weakness.

Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.

Cardiovascular system: rarely - chest pain.

Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.

Other: rarely - hyperglycemia, arthralgia.

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Contraindications

Hypersensitivity to azithromycin and other macrolide antibiotics.

Using during pregnancy and breastfeeding

azithromycin crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary to use azithromycin in the lactation period should solve the issue of termination of breastfeeding.

Special instructions

azithromycin not recommended for use in patients with compromised liver function.

azithromycin uses with careful with impaired renal function.

This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.

azithromycin drug interactions

Simultaneous administration of azithromycin with these drugs and medications may has followed effects:

  • ergot alkaloids: can not been exclude the risk of ergotism;
  • warfarin: there was described amplification effect of warfarin;
  • digoxin or digitoxin: may be significantly increase the concentration of cardiac glycosides in plasma and risk of glycoside intoxication;
  • disopyramide: described a case of ventricular fibrillation;
  • lovastatin: there was describes some cases of rhabdomyolysis;
  • azithromycin with rifabutin increases risk of neutropenia and leukopenia;
  • cyclosporine: disturbed metabolism of cyclosporine which increases the risk of adverse and toxic reactions caused by cyclosporine

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    Azithromycin available forms, composition, doses:

    Price
    AZITHROMYCIN 250MG TABLET
    AZITHROMYCIN 600MG TABLET
    Apo-Azithromycin 250 mg Tablet3.11 USD
    Azasite 1% eye drops42.85 USD
    Azithromycin 2.5 gm bulk vial75.6 USD
    Azithromycin 200 mg/5ml Suspension 15ml Bottle34.25 USD
    Azithromycin 250 mg tablet6.33 USD
    Azithromycin 3 500 mg tablet Disp Pack48.52 USD
    Azithromycin 500 mg tablet15.87 USD
    Azithromycin 6 250 mg tablet Disp Pack48.52 USD
    Azithromycin 600 mg tablet19.04 USD
    Azithromycin i.v. 500 mg vial11.09 USD
    Azithromycin powder10.89 USD
    Capsules; Oral; Azithromycin 250 mg
    Capsules; Oral; Azithromycin Dihydrate 250 mg
    Co Azithromycin 250 mg Tablet3.11 USD
    For Suspension; Oral; Azithromycin 100 mg / 5 ml
    For Suspension; Oral; Azithromycin 200 mg / 5 ml
    Injectable; Injection; Azithromycin 500 mg
    Injectable; Injection; Azithromycin Hydrogen Citrate 2.5 g
    Injectable; Injection; Azithromycin Hydrogen Citrate 500 mg
    Injectable; Injection; Azithromycin Monohydrate 50 mg / ml
    Injectable; Injection; Azithromycin Monohydrate 500 mg
    Mylan-Azithromycin 250 mg Tablet3.11 USD
    Novo-Azithromycin 20 mg/ml Suspension0.67 USD
    Novo-Azithromycin 250 mg Tablet3.11 USD
    Novo-Azithromycin 40 mg/ml Suspension0.95 USD
    Phl-Azithromycin 250 mg Tablet3.11 USD
    Pms-Azithromycin 20 mg/ml Suspension0.67 USD
    Pms-Azithromycin 250 mg Tablet3.11 USD
    Pms-Azithromycin 40 mg/ml Suspension0.95 USD
    Powder for Solution; Intravenous; Azithromycin Hydrogen Citrate 500 mg
    Powder for Suspension, Oral; Azithromycin 100 mg / 5 ml
    Powder for Suspension, Oral; Azithromycin 200 mg / 5 ml
    Powder for Suspension; Oral; Azithromycin 100 mg / 5 ml
    Powder for Suspension; Oral; Azithromycin 200 mg / 5 ml
    Ratio-Azithromycin 250 mg Tablet3.11 USD
    Sandoz Azithromycin 20 mg/ml Suspension0.67 USD
    Sandoz Azithromycin 250 mg Tablet3.11 USD
    Sandoz Azithromycin 40 mg/ml Suspension0.95 USD
    Suspension; Oral; Azithromycin 100 mg / 5 ml
    Suspension; Oral; Azithromycin 200 mg / 5 ml
    Tablets, Film-Coated; Oral; Azithromycin 250 mg
    Tablets, Film-Coated; Oral; Azithromycin 500 mg
    Tablets, Film-Coated; Oral; Azithromycin Monohydrate 250 mg
    Tablets, Film-Coated; Oral; Azithromycin Monohydrate 500 mg
    Tablets; Oral; Azithromycin 250 mg
    Tablets; Oral; Azithromycin 500 mg
    Tablets; Oral; Azithromycin 600 mg
    Tablets; Oral; Azithromycin Monohydrate 250 mg
    Tablets; Oral; Azithromycin Monohydrate 600 mg
    Trimox 125 mg/5ml Suspension 100ml Bottle11.99 USD
    Trimox 125 mg/5ml Suspension 150ml Bottle11.99 USD
    Trimox 250 mg/5ml Suspension 80ml Bottle11.99 USD
    Zithromax 100 mg/5ml Suspension 15ml Bottle51.6 USD
    Zithromax 20 mg/ml Suspension1.2 USD
    Zithromax 200 mg/5ml Suspension 15ml Bottle50.46 USD
    Zithromax 200 mg/5ml Suspension 22.5ml Bottle50.46 USD
    Zithromax 200 mg/5ml Suspension 30ml Bottle52.0 USD
    Zithromax 250 mg tablet9.41 USD
    Zithromax 250 mg z-pak tablet11.12 USD
    Zithromax 3 1 gm Packets Box118.26 USD
    Zithromax 40 mg/ml Suspension1.7 USD
    Zithromax 500 mg tablet22.68 USD
    Zithromax 600 mg tablet27.22 USD
    Zithromax Tri-Pak 3 500 mg tablet Disp Pack69.67 USD
    Zithromax Z-Pak 6 250 mg tablet Disp Pack68.62 USD
    Zithromax i.v. 500 mg vial34.39 USD
    Zithromax tri-pak 500 mg tablet22.24 USD
    Zmax 2 g/60 ml susp sr67.04 USD
    Zmax adult-ped 2 g/60 ml susp70.39 USD
    Zmax pediatric 2 g/60 ml susp67.04 USD

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    Indications and Usages:

    ATC codes:


    ICD-10 codes:


    Azithromycin destination | category:


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    Drugs with same active ingredients (Pharmaceutical companies):


    References

    1. Dailymed."AZITHROMYCIN TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."AZITHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "azithromycin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Azithromycin?

    Depending on the reaction of the Azithromycin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Azithromycin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Azithromycin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Azithromycin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Azithromycin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug Azithromycin useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Useful1
    100.0%

    One visitor reported side effects

    Did you get side effects while taking the Azithromycin drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Azithromycin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    No side effects1
    100.0%

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Azithromycin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Not expensive1
    100.0%

    Eight visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Azithromycin drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Azithromycin is mentioned below.
    Visitors%
    Once in a day4
    50.0%
    Twice in a day3
    37.5%
    4 times in a day1
    12.5%

    Six visitors reported doses

    What is the dose of Azithromycin drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 501mg-1g. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    501mg-1g3
    50.0%
    201-500mg3
    50.0%

    One visitor reported time for results

    What is the time duration Azithromycin drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 week to notice the result from using Azithromycin drug. The time needed to show improvement in health condition after using the medicine Azithromycin need not be same for all the users. It varies based on other factors.
    Visitors%
    1 week1
    100.0%

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Azithromycin drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    After food1
    100.0%

    Five visitors reported age

    Visitors%
    46-602
    40.0%
    16-292
    40.0%
    1-51
    20.0%

    Visitor reviews


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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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