Citalopram-RL

Citalopram-RL uses

• Pharmacological action
• Pharmacokinetics
• Why is Citalopram-RL prescribed?
• Dosage and administration
• Citalopram-RL side effects, adverse reactions
• Citalopram-RL contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Citalopram-RL drug interactions
• Citalopram-RL in case of emergency / overdose
• Citalopram-RL reviews

Pharmacological action

Citalopram-RL is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Citalopram-RL lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.

Pharmacokinetics

After oral administration C_max of Citalopram-RL in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Citalopram-RL are linear. C_ss in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Citalopram-RL is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T_1/2 is 1.5 days.

Citalopram-RL is excreted by the kidneys and the bowel.

Why is Citalopram-RL prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Citalopram-RL is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Citalopram-RL is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Citalopram-RL side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.

Citalopram-RL contraindications

Hypersensitivity to Citalopram-RL; simultaneous taking MAO inhibitors.

Using during pregnancy and breastfeeding

Safety of Citalopram-RL during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Citalopram-RL on reproduction and prenatal development of the fetus.

Special instructions

In patients with liver failure Citalopram-RL should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Citalopram-RL Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Citalopram-RL it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Citalopram-RL may cause a more pronounced bradycardia.

The efficacy and safety of Citalopram-RL in children has not been established.

Citalopram-RL should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Citalopram-RL in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Citalopram-RL drug interactions

Simultaneous administration of Citalopram-RL with: