Active ingredient: Citalopram Hydrobromide

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Citalopram Hydrobromide uses

Pharmacological action

Citalopram Hydrobromide is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Citalopram Hydrobromide lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.


After oral administration Cmax of Citalopram Hydrobromide in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Citalopram Hydrobromide are linear. Css in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Citalopram Hydrobromide is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T1/2 is 1.5 days.

Citalopram Hydrobromide is excreted by the kidneys and the bowel.

Why is Citalopram Hydrobromide prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Citalopram Hydrobromide is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Citalopram Hydrobromide is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Citalopram Hydrobromide side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.


Citalopram Hydrobromide contraindications

Hypersensitivity to Citalopram Hydrobromide; simultaneous taking MAO inhibitors.

Using during pregnancy and breastfeeding

Safety of Citalopram Hydrobromide during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Citalopram Hydrobromide on reproduction and prenatal development of the fetus.

Special instructions

In patients with liver failure Citalopram Hydrobromide should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Citalopram Hydrobromide Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Citalopram Hydrobromide it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Citalopram Hydrobromide may cause a more pronounced bradycardia.

The efficacy and safety of Citalopram Hydrobromide in children has not been established.

Citalopram Hydrobromide should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Citalopram Hydrobromide in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Citalopram Hydrobromide drug interactions

Simultaneous administration of Citalopram Hydrobromide with:

  • MAO inhibitors may develop a hypertensive crisis ;
  • cimetidine may moderate increase in Css of Citalopram Hydrobromide in plasmaThe inhibitory effect on CYP2D6 isoenzyme is expressed very poorly, so the interaction with drugs that affect the metabolism of this enzyme is minimal. But we can not exclude the decrease in the concentration of Citalopram Hydrobromide in plasma by increasing its metabolism by carbamazepine induction of liver enzymes in their simultaneous application.

    The effects of sumatriptan and other serotonergic medications can be amplified by Citalopram Hydrobromide in their simultaneous application.

    Citalopram Hydrobromide in case of emergency / overdose

    Symptoms: dizziness, sweating, nausea, vomiting, tremor, somnolence, sinus tachycardia. In more rare cases - amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, ECG changes.

    Treatment: gastric lavage and use of activated carbon. Maintaining an airway to ensure adequate ventilation and oxygenation. It is recommended careful observation and monitoring of vital functions. Due to the large volume of distribution of Citalopram Hydrobromide is unlikely efficiency such measures as forced diuresis, dialysis, hemoperfusion and exchange transfusion. There is no specific antidote.

    Citalopram Hydrobromide available forms, composition, doses:

    Indications and Usages:

    ATC codes:

    ICD-10 codes:

    Citalopram Hydrobromide destination | category:


    Drugs with same active ingredients (Pharmaceutical companies):


    2. "citalopram". (accessed August 28, 2018).
    3. "citalopram". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Citalopram Hydrobromide?

    Depending on the reaction of the Citalopram Hydrobromide after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Citalopram Hydrobromide not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Citalopram Hydrobromide addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Citalopram Hydrobromide, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Citalopram Hydrobromide consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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