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DRUGS & SUPPLEMENTS
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Aciclodan
What is the dose of the medication you are taking? |
Aciclodan uses
Pharmacological action
Aciclodan is an antiviral agent. Thymidine kinase of virus-infected cells actively converts Aciclodan through a series of sequential reactions in the mono-, di- and triphosphate of Aciclodan. The latter interacts with the viral DNA polymerase, and embedded in DNA, which is synthesized for new viruses. Thus it is formed a "defective" viral DNA which leads to suppression of replication of new generations of viruses.
This mediciine Aciclodan is active against Herpes Simplex virus types 1 and 2, Varicella Zoster virus, Epstein-Barr virus and cytomegalovirus.
Pharmacokinetics
For oral administration bioavailability is 15-30%. Widely distributed in tissues and body fluids. Plasma protein binding is 9-33%. Metabolised in liver. T1/2 for oral administration - 3.3 h, intravenous - 2.5 hours; Aciclodan excreted in the urine, also in small quantities - with feces.
Why is Aciclodan prescribed?
For systemic use : infections caused by Herpes Simplex virus types 1 and 2 and Varicella Zoster; prevention of infections caused by viruses Herpes Simplex and Varicella Zoster (including in patients with low immunity); in combined therapy with the pronounced immunodeficiency (including in the clinical picture of HIV infection) and in patients undergoing marrow transplantation, prevention of cytomegalovirus infection after marrow transplantation.
For topical use in ophthalmology: keratitis and other eye damage caused by Herpes Simplex virus.
For external use: infections of the skin caused by Herpes Simplex virus and Varicella Zoster like Herpes Simplex of the skin and mucous membranes, genital herpes (primary and recurrent) localized zoster (support therapy).
Dosage and administration
Aciclodan for oral usage for adults and children older than 2 years - 200-400 mg of 3-5 times / day, if necessary - to 20 mg / kg (up to 800 mg per dose) 4 times / day. For children under 2 years are used in doses equal to half the adult dose. Duration of treatment - 5-10 days. In renal insufficiency is recommended correction dosing regimen.
IV in adults and children over 12 years - 5-10 mg / kg, the interval between infusions - 8 hours. Children under the age of 3 months to 12 years - 250-500 mg / m2 body surface, the interval between infusions - 8 hours, for infants dose is 10 mg / kg, the interval between infusions - 8 hours.
In renal insufficiency must be corrected dosing regimen.
Locally and externally applied 5 times / 24 h. Dose and duration of treatment depends on the testimony and the use of dosage form.
Maximum dose for adults for IV usage is 30 mg / kg / 24 h.
Aciclodan side effects, adverse reactions
For oral usage: nausea, vomiting, diarrhea, abdominal pain, skin rash, headache, dizziness, fatigue, reduced concentration, hallucinations, drowsiness or insomnia, fever, rarely - hair loss, a transient increase in blood concentrations of bilirubin, urea, creatinine, liver enzymes, lymphocytopenia, eritropeniya, leukopenia.
For IV usage: acute renal failure, crystalluria, encephalopathy, phlebitis, or inflammation at the injection site, nausea, vomiting.
For topically usage: a burning sensation in the application area, superficial punctate keratitis, blepharitis, conjunctivitis.
For external usage: in the application area may be a burning sensation, skin rash, itching, peeling, erythema, dry skin in contact with mucous membranes - inflammation.
Contraindications
Hypersensitivity to Aciclodan and valaciclovir; for IV usage - lactation (breast feeding).
Using during pregnancy and breastfeeding
Pregnancy. Perhaps, if the expected effect of the therapy outweighs the potential risk to the fetus ; Aciclodan passes through the placenta. Data on the outcome of pregnancy in women taking Aciclodan systemic action in the I trimester of pregnancy showed no increase in birth defects compared with the total population. Since the observation was included a small number of women, reliable and definitive conclusions about the safety of Aciclodan in pregnancy can be done.
Breastfeeding. Aciclodan penetrates into breast milk. After taking Aciclodan by mouth, it was determined in breast milk in concentrations, the ratio of which, with concentrations in blood plasma was 0,6-1,4. At these concentrations in breast milk, children who are breastfed can receive Aciclodan at a dose of 0.3 mg / kg / day. Given this, should appoint Aciclodan lactating women with caution, only if necessary.
Special instructions
Do not use Aciclodan with severely impaired renal function.
Note that the application of Aciclodan may develop acute renal failure due to precipitate formation of crystals of Aciclodan, which is especially likely during rapid IV introduction, the simultaneous use of nephrotoxic drugs in patients with impaired renal function and lack of water stress.
When applying aciclovir should monitor renal function (determination of the level in the blood urea nitrogen and creatinine in blood plasma).
Treatment of elderly patients should be conducted with a sufficient increase in water load and under the supervision of a physician, because among these patients increased half-life of Aciclodan.
In the treatment of genital herpes should avoid sex or use condoms, because use of Aciclodan does not prevent transmission to partners.
This medication Aciclodan in the form of dosage forms for topical use should not be applied to mucous membranes of the mouth, eyes, vagina.
Aciclodan drug interactions
With simultaneous use of probenecid decreases the tubular secretion of Aciclodan, and thereby increases the concentration in blood plasma and the half-life of Aciclodan.
With simultaneous use of Aciclodan with other nephrotoxic drugs increases the risk of nephrotoxicity.
Enhancing effect of Aciclodan is noted while appointing immunostimulators.
When mixed solutions should be considered an alkaline reaction to Aciclodan for IV introduction (pH 11).
Aciclodan in case of emergency / overdose
Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, renal failure, lethargy, convulsions, coma.
Treatment: symptomatic therapy, the maintenance of vital functions, adequate hydration, hemodialysis (especially in acute renal failure and anuria).There is no data for overdose when applied topically.
Aciclodan pharmaceutical active ingredients containing related brand and generic drugs:
Aciclodan available forms, composition, doses:
Aciclodan destination | category:
Aciclodan Anatomical Therapeutic Chemical codes:
Aciclodan pharmaceutical companies:
References
- Dailymed."ACYCLOVIR TABLET [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."ACYCLOVIR: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "acyclovir". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Aciclodan?Depending on the reaction of the Aciclodan after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Aciclodan not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Aciclodan addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Aciclodan, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Aciclodan consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetTwo visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Aciclodan drug as prescribed by the doctor?
Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Aciclodan is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| 4 times in a day | 1 | 50.0% | |
| Once in a day | 1 | 50.0% | |
Visitor reported doses
No survey data has been collected yetOne visitor reported time for results
What is the time duration Aciclodan drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 days to notice the result from using Aciclodan drug. The time needed to show improvement in health condition after using the medicine Aciclodan need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 3 days | 1 | 100.0% | |
One visitor reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Aciclodan drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Empty stomach | 1 | 100.0% | |
Visitor reported age
No survey data has been collected yetVisitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology