Active ingredient: Tetanus Immune Globulin Human

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Tetanus Immune Globulin Human uses


HyperTET S/D is indicated for prophylaxis against tetanus following injury in patients whose immunization is incomplete or uncertain. It is also indicated, although evidence of effectiveness is limited, in the regimen of treatment of active cases of tetanus. [7,8,15]

A thorough attempt must be made to determine whether a patient has completed primary vaccination. Patients with unknown or uncertain previous vaccination histories should be considered to have had no previous tetanus toxoid doses. Persons who had military service since 1941 can be considered to have received at least one dose, and although most of them may have completed a primary series of tetanus toxoid, this cannot be assumed for each individual. Patients who have not completed a primary series may require tetanus toxoid and passive immunization at the time of wound cleaning and debridement. [2]

The following table is a summary guide to tetanus prophylaxis in wound management:

History of Tetanus Immunization


Clean, Minor Wounds All Other Wounds Such as, but not limited to, wounds contaminated with dirt, feces, soil, and saliva; puncture wounds; avulsions; and wounds resulting from missiles, crushing, burns and frostbite.
Td Adult type tetanus and diphtheria toxoids. If the patient is less than 7 years old, DT or DTP is preferred to tetanus toxoid alone. For persons ≥7 years of age, Td is preferred to tetanus toxoid alone. TIG Tetanus Immune Globulin Human (Human). Td TIG
Uncertain or less than 3 Yes No Yes Yes
3 or more If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given. No Yes if more than 10 years since the last dose. No No Yes if more than 5 years since the last dose. (More frequent boosters are not needed and can accentuate side effects). No


None known.


HyperTET S/D is made from human plasma. Products made from human plasma may contain infectious agents, such as viruses, and, theoretically, the Creutzfeldt-Jakob Disease (CJD) agent that can cause disease. The risk that such products will transmit an infectious agent has been reduced by screening plasma donors for prior exposure to certain viruses, by testing for the presence of certain current virus infections, and by inactivating and/or removing certain viruses. Despite these measures, such products can still potentially transmit disease. There is also the possibility that unknown infectious agents may be present in such products. Individuals who receive infusions of blood or plasma products may develop signs and/or symptoms of some viral infections, particularly hepatitis C. ALL infections thought by a physician possibly to have been transmitted by this product should be reported by the physician or other healthcare provider to Grifols Therapeutics Inc. [1-800-520-2807].

The physician should discuss the risks and benefits of this product with the patient, before prescribing or administering it to the patient.

HyperTET S/D should be given with caution to patients with a history of prior systemic allergic reactions following the administration of human immunoglobulin preparations.

In patients who have severe thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections, HyperTET S/D should be given only if the expected benefits outweigh the risks.



HyperTET S/D should not be given intravenously. Intravenous injection of immunoglobulin intended for intramuscular use can, on occasion, cause a precipitous fall in blood pressure, and a picture not unlike anaphylaxis. Injections should only be made intramuscularly and care should be taken to draw back on the plunger of the syringe before injection in order to be certain that the needle is not in a blood vessel. Intramuscular injections are preferably administered in the deltoid muscle of the upper arm or lateral thigh muscle. The gluteal region should not be used as an injection site because of the risk of injury to the sciatic nerve. [16]

Chemoprophylaxis against tetanus is neither practical nor useful in managing wounds. Wound cleaning, debridement when indicated, and proper immunization are important. The need for tetanus toxoid, with or without TIG (passive immunization), depends on both the condition of the wound and the patient’s vaccination history. Rarely has tetanus occurred among persons with documentation of having received a primary series of toxoid injections. [2] See table under INDICATIONS AND USAGE.

Skin tests should not be done. The intradermal injection of concentrated IgG solutions often causes a localized area of inflammation which can be misinterpreted as a positive allergic reaction. In actuality, this does not represent an allergy; rather, it is localized tissue irritation. Misinterpretation of the results of such tests can lead the physician to withhold needed human antitoxin from a patient who is not actually allergic to this material. True allergic responses to human IgG given in the prescribed intramuscular manner are rare.

Although systemic reactions to human immunoglobulin preparations are rare, epinephrine should be available for treatment of acute anaphylactic reactions.

Drug Interactions

Antibodies in immunoglobulin preparations may interfere with the response to live viral vaccines such as measles, mumps, polio, and rubella. Therefore, use of such vaccines should be deferred until approximately 3 months after Tetanus Immune Globulin Human (Human) - HyperTET ® S/D administration.

No interactions with other products are known.

Pregnancy Category C

Animal reproduction studies have not been conducted with HyperTET S/D. It is also not known whether HyperTET S/D can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. HyperTET S/D should be given to a pregnant woman only if clearly needed.

Pediatric Use

Safety and effectiveness in the pediatric population have not been established.



Slight soreness at the site of injection and slight temperature elevation may be noted at times. Sensitization to repeated injections of human immunoglobulin is extremely rare.

In the course of routine injections of large numbers of persons with immunoglobulin there have been a few isolated occurrences of angioneurotic edema, nephrotic syndrome, and anaphylactic shock after injection.


Although no data are available, clinical experience with other immunoglobulin preparations suggests that the only manifestations would be pain and tenderness at the injection site.


Routine prophylactic dosage schedule:

Treatment of active cases of tetanus:

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. They should not be used if particulate matter and/or discoloration are present.

HyperTET S/D is supplied with a syringe and an attached UltraSafe® Needle Guard for your protection and convenience. Please follow instructions below for proper use of syringe and UltraSafe® Needle Guard.

Directions for Syringe Usage

A number of factors could reduce the efficacy of this product or even result in an ill effect following its use. These include improper storage and handling of the product after it leaves our hands, diagnosis, dosage, method of administration, and biological differences in individual patients. Because of these factors it is important that this product be stored properly and that the directions be followed carefully during use.



HyperTET S/D is supplied in 250 unit prefilled disposable syringes with attached needles. HyperTET S/D is preservative-free, in a latex-free delivery system.

NDC Number Size
13533-634-02 250 unit syringe


Store at 2–8°C (36–46°F). Solution that has been frozen should not be used.


Rx only

U.S. federal law prohibits dispensing without prescription.


Grifols Therapeutics Inc.

Research Triangle Park, NC 27709 USA

U.S. License No. 1871


(Rev. September 2012)

Tetanus Immune Globulin Human (Human)

HyperTET ® S/D

Solvent/Detergent Treated


latex-free delivery system

250 Units

Contents: One single dose disposable syringe with attached needle.

Tetanus Immune Globulin Human (Human) is a sterile solution of immunoglobulin containing 15%–18% protein stabilized with 0.21–0.32M glycine. The pH is adjusted with sodium carbonate.

The potency of each syringe is not less than 250 antitoxin units based on the U.S. Standard Antitoxin and the U.S. Control Tetanus Toxin.


Store at 2–8°C (36–46°F).

Do not freeze.

NDC 13533-634-02


The patient and physician should discuss the risks and benefits of this product.

For complete dosage and administration information, read enclosed package insert.

For directions for syringe usage, see enclosed package insert.

Do not use if the syringe is prematurely engaged.

Not returnable for credit or exchange.

Rx only

CAUTION: U.S. federal law prohibits dispensing without prescription.

Grifols Therapeutics Inc.

Research Triangle Park,

NC 27709 USA

U.S. License No. 1871

Carton: 08940722

Tetanus Immune Globulin Human (Human)

HyperTET ® S/D

Solvent/Detergent Treated

250 Units

Grifols Therapeutics Inc.

Research Triangle Park,

NC 27709 USA

U.S. License No. 1871

The patient and physician should discuss the risks and benefits of this product.




Tetanus Immune Globulin Human available forms, composition, doses:

Indications and Usages:

ATC codes:

ICD-10 codes:

Tetanus Immune Globulin Human destination | category:


Drugs with same active ingredients (Pharmaceutical companies):

Frequently asked Questions

Can i drive or operate heavy machine after consuming Tetanus Immune Globulin Human?

Depending on the reaction of the Tetanus Immune Globulin Human after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tetanus Immune Globulin Human not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Tetanus Immune Globulin Human addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Tetanus Immune Globulin Human, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Tetanus Immune Globulin Human consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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