Active ingredient: Ranitidine

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Ranitidine uses

Pharmacological action

ranitidine is a blocker of histamine H2-receptors. Inhibits basal and stimulated by histamine, gastrin and acetylcholine the secretion of hydrochloric acid. Increases the pH of gastric contents and reduces the activity of pepsin. The duration of action of ranitidine with a single admission - 12 hours.


After oral administration, ranitidine is rapidly absorbed from the gastrointestinal tract. Eating and antacids significantly affect the extent of absorption. Subjected to the effect of "first passage" through the liver. Cmax in plasma is reached within 2 h after a single oral administration. After IM injection ranitidine rapidly and almost completely absorbed from the injection site. Cmax achieved within 15 min.

Protein binding - 15%. Vd - 1.4 L / kg. ranitidine is excreted in breast milk.

T1/2 is 2-3 h. About 30% of the dose excreted in the urine in unchanged form. Elimination rate decreases with abnormal liver function or renal function.

Why is ranitidine prescribed?

Gastric ulcer and duodenal ulcer in acute phase; prevention of relapse of peptic ulcer; symptomatic ulcer; erosive and reflux esophagitis; Zollinger-Ellison syndrome; prevention of "stress" ulcers of the gastrointestinal tract, postoperative ulcers, recurrent bleeding from upper gastrointestinal tract; prevention of aspiration of gastric juice during operations under general anesthesia.

Dosage and administration

Individual. For oral administration for treatment of adults and children over 14 years daily ranitidine dose is 300-450 mg; if necessary, the daily dose was increased to 600-900 mg; multiplicity of administration is 2-3 times / day. For the prevention of exacerbations of disease are used by 150 mg / day at bedtime. The duration of treatment is determined by the indications for use.

The dose of ranitidine for patients with renal insufficiency at the level of creatinine more than 3.3 mg / 100 ml is 75 mg 2 times / day.

IV or IM by 50-100 mg every 6-8 hours.


ranitidine side effects, adverse reactions

Cardio-vascular system: in a few cases - AV-blockade.

Digestive system: rarely - diarrhea, constipation, and in isolated cases - hepatitis.

CNS: Rarely - headache, dizziness, fatigue, blurred vision, and in isolated cases (at seriously ill patients) - confusion, hallucinations.

Hematopoietic system: rarely - thrombocytopenia, prolonged use at high doses - leukopenia.

Metabolism: rarely - a slight increase of creatinine in serum at the beginning of treatment.

Endocrine system: long-term use in high doses may increase the content of prolactin, gynecomastia, amenorrhea, impotence, decreased libido.

From the musculoskeletal system: very rarely - arthralgia, myalgia.

Allergic reactions: rarely - a skin rash, urticaria, angioedema, anaphylactic shock, bronchospasm, hypotension.

Other: rarely - recurrent parotitis, and in isolated cases - hair loss.

ranitidine contraindications

Pregnancy, lactation (breastfeeding), increased sensitivity to ranitidine.

Using during pregnancy and breastfeeding

Adequate and well controlled studies of the safety of ranitidine during pregnancy has not been conducted, therefore the use during pregnancy is contraindicated.

If necessary the use of ranitidine during lactation should stop breastfeeding.

Special instructions

With careful use in patients with impaired renal excretory function.

Before treatment with ranitidine is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.

With long-term treatment of debilitated patients under stress conditions may be bacterial lesions of the stomach with subsequent spread of infection.

Undesirable abrupt discontinuation of ranitidine because of the risk of recurrence of peptic ulcer. Effectiveness of prophylactic treatment of peptic ulcer above while taking ranitidine courses for 45 days in spring and autumn than during the reception. Quick intravenous injection of ranitidine in rare cases cause bradycardia, usually in patients predisposed to cardiac arrhythmias.

There are a few reports that ranitidine might contribute to the development of acute attacks of porphyria, in connection with what is necessary to avoid its use in patients with acute porphyria in history.

Therapy with ranitidine possible distortions of laboratory data: increased creatinine, the activity of gamma-glutamyl transpeptidase and liver transaminases in the blood plasma.

In cases where ranitidine is used in combination with antacids, the break between taking antacids and ranitidine should be at least 1-2 hours.

Clinical data on the safety of ranitidine in pediatric patients is limited.

ranitidine drug interactions

In an application with antacids may decrease absorption of ranitidine.

In an application of ranitidine with anticholinergics may be in breach of memory and attention in elderly patients.

Probably that histamine H2-blockers reduce receptor ulcerogenic action of NSAIDs on the gastric mucosa.

In an application with warfarin may decrease clearance of warfarin. There is one case of gipoprotrombinemiey and bleeding in patients receiving warfarin.

In an application with bismuth tripotassium dicitrate may increase unwanted absorption of bismuth, with glyburide - described the cases of hypoglycemia, with ketoconazole, itraconazole - decreased absorption of ketoconazole, itraconazole.

In an application with metoprolol may increase the plasma concentrations and increased AUC and T1 / 2 of metoprolol.

In an application with sucralfate in high doses (2 g) possible violation of the absorption of ranitidine.

In an application ranitidine with procainamide may be decrease excretion of procainamide by the kidneys which leads to an increase in its concentration in blood plasma.

There is a data of increased absorption of triazolam in its simultaneous application, apparently due to changes in pH of gastric contents under the influence of ranitidine.

Probably that while the application with phenytoin may increase the concentration of phenytoin in plasma and increased risk of toxicity.

In an application with furosemide moderately expressed increasing the bioavailability of furosemide.

There is a described case of ventricular arrhythmias (bigeminy) with simultaneous application of quinidine, with cisapride - described a case of cardiotoxicity.

It can not be excluded some increase in cyclosporine concentration in blood plasma in its simultaneous application with ranitidine.

ranitidine in case of emergency / overdose

Symptoms: seizures, bradycardia, ventricular arrhythmias.

Treatment: induction of vomiting or gastric lavage, symptomatic therapy. In convulsions - diazepam IV, bradycardia - atropine, ventricular arrhythmias - lidocaine.


Ranitidine available forms, composition, doses:

Acid reducer 150 mg tablet0.2 USD
Acid reducer 75 mg tablet0.11 USD
Apo-Ranitidine 15 mg/ml Solution0.12 USD
Apo-Ranitidine 150 mg Tablet0.42 USD
Apo-Ranitidine 300 mg Tablet0.82 USD
CVS Pharmacy acid reducer 75 mg tablet0.11 USD
CVS Pharmacy ranitidine 75 mg tablet0.15 USD
Capsules; Oral; Ranitidine Hydrochloride 150 mg
Capsules; Oral; Ranitidine Hydrochloride 300 mg
Co Ranitidine 150 mg Tablet0.42 USD
Co Ranitidine 300 mg Tablet0.82 USD
Injectable; Injection; Ranitidine 25 mg / ml
Injectable; Injection; Ranitidine Hydrochloride 25 mg / ml
Mylan-Ranitidine 150 mg Tablet0.42 USD
Mylan-Ranitidine 300 mg Tablet0.82 USD
Novo-Ranidine 15 mg/ml Solution0.12 USD
Novo-Ranidine 150 mg Tablet0.19 USD
Novo-Ranidine 300 mg Tablet0.38 USD
Nu-Ranit 150 mg Tablet0.42 USD
Nu-Ranit 300 mg Tablet0.82 USD
Phl-Ranitidine 150 mg Tablet0.19 USD
Phl-Ranitidine 300 mg Tablet0.38 USD
Pms-Ranitidine 150 mg Tablet0.42 USD
Pms-Ranitidine 300 mg Tablet0.82 USD
Qc ranitidine 75 mg tablet0.07 USD
Ran-Ranitidine 150 mg Tablet0.42 USD
Ran-Ranitidine 300 mg Tablet0.82 USD
Ranitidine 150 mg tablet1.48 USD
Ranitidine 25 mg/ml1.26 USD
Ranitidine 300 mg tablet2.69 USD
Ranitidine HCl 15 mg/ml Syrup1.0 USD
Ranitidine HCl 150 mg capsule1.58 USD
Ranitidine HCl 150 mg tablet1.54 USD
Ranitidine HCl 300 mg capsule2.85 USD
Ranitidine HCl 300 mg tablet2.79 USD
Ranitidine hcl 25 mg/ml vial2.0 USD
Ranitidine hcl 75 mg tablet0.22 USD
Ranitidine hcl powder5.2 USD
Ratio-Ranitidine 150 mg Tablet0.42 USD
Ratio-Ranitidine 300 mg Tablet0.82 USD
Sandoz Ranitidine 150 mg Tablet0.19 USD
Sandoz Ranitidine 300 mg Tablet0.38 USD
Sm acid reducer 75 mg tablet0.22 USD
Solution; Oral; Ranitidine 15 mg / ml
Solution; Oral; Ranitidine Hydrochloride 15 mg / ml
Solution; Oral; Ranitidine Hydrochloride 150 mg / 10 ml
Syrup; Oral; Ranitidine Hydrochloride 15 mg / ml
Tablets, Effervescent; Oral; Ranitidine 150 mg
Tablets, Effervescent; Oral; Ranitidine 300 mg
Tablets, Effervescent; Oral; Ranitidine Hydrochloride 150 mg
Tablets, Effervescent; Oral; Ranitidine Hydrochloride 300 mg
Tablets, Effervescent; Oral; Ranitidine Hydrochloride 75 mg
Tablets, Film-Coated; Oral; Ranitidine 150 mg
Tablets, Film-Coated; Oral; Ranitidine 300 mg
Tablets, Film-Coated; Oral; Ranitidine Hydrochloride 150 mg
Tablets, Film-Coated; Oral; Ranitidine Hydrochloride 300 mg
Tablets; Oral; Ranitidine Hydrochloride 150 mg
Tablets; Oral; Ranitidine Hydrochloride 300 mg
Tablets; Oral; Ranitidine Hydrochloride 75 mg
Wal-zan 75 mg tablet0.27 USD
Wal-zan 75 tablet0.2 USD
Zantac 15 mg/ml Solution0.23 USD
Zantac 15 mg/ml Syrup0.81 USD
Zantac 150 mg tablet0.19 USD
Zantac 25 efferdose tablet4.02 USD
Zantac 25 mg/ml1.58 USD
Zantac 25 mg/ml vial2.0 USD
Zantac 300 mg tablet0.38 USD
Zantac 75 mg tablet0.28 USD
Zantac 75 tablet0.49 USD
Zantac EFFERdose 25 mg Effervescent Tabs4.18 USD


Indications and Usages:

ATC codes:

ICD-10 codes:

Ranitidine destination | category:


Drugs with same active ingredients (Pharmaceutical companies):


  2. "ranitidine". (accessed August 28, 2018).
  3. "ranitidine". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Ranitidine?

Depending on the reaction of the Ranitidine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ranitidine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Ranitidine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Ranitidine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ranitidine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Ranitidine drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of website users about the frequency of taking the drug Ranitidine is mentioned below.
Once in a day1

Two visitors reported doses

What is the dose of Ranitidine drug you are taking?
According to the survey conducted among website users, the maximum number of people are using the following dose 101-200mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

Two visitors reported time for results

What is the time duration Ranitidine drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say website users needed 1 month to notice the result from using Ranitidine drug. The time needed to show improvement in health condition after using the medicine Ranitidine need not be same for all the users. It varies based on other factors.
1 month1
> 3 month1

Visitor reported administration

No survey data has been collected yet

One visitor reported age

> 601

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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