DRUGS & SUPPLEMENTS
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Paroxetine Hydrochloride is an antidepressant, selective serotonin reuptake inhibitor. This medication has a bicyclic structure distinct from the structures of other known antidepressants. Paroxetine Hydrochloride has antidepressant and anxiolytic effects when expressed enough incentive effect.
Antidepressant (thymoleptic) action is related to the ability of Paroxetine Hydrochloride selectively block the reuptake of serotonin presynaptic membrane than is caused by increase of free content of this neurotransmitter in the synaptic cleft and enhancement of its activity in the CNS.
Effect on the m-cholinergic receptors, alpha- and beta-adrenergic receptors is only slightly which determines the extremely weak intensity of the side effects.
After oral administration Paroxetine Hydrochloride is well absorbed from the gastrointestinal tract. Ingestion did not affect absorption. Css is set to the 7-14 day since the start of therapy. The major metabolites of Paroxetine Hydrochloride are polar and conjugated products of oxidation and methylation. Due to the low pharmacological activity of metabolites their impact on therapeutic efficacy is unlikely.
T1/2 on average is 16-24 hours. Less than 2% excreted in the urine in unchanged form, the rest - in the form of metabolites or urine (64%), or bile.
Excretion of Paroxetine Hydrochloride is biphasic.
With long-term continuous using of this drug pharmacokinetic parameters do not change.
Endogenous, neurotic and reactive depression.
When Paroxetine Hydrochloride administered orally an initial dose is 10-20 mg / day. If necessary, depending on the evidence, the dose was increased to 40-60 mg / day. Increasing the dose spend gradually on 10 mg with intervals of 1 week. Frequency of admission is 1 time / day. The treatment of long-term. Treatment's efficacy is assessed after 6-8 weeks.
For elderly and debilitated patients, as well as renal impairment and hepatic the initial dose is 10 mg / day, the maximum dose is 40 mg / day.
CNS: rarely - drowsiness, tremor, fatigue, insomnia.
Digestive system: rarely (when used in doses more than 20 mg) - nausea, dry mouth, and in some cases constipation. Other: rarely (when used in doses more than 20 mg) - increased sweating, ejaculation disorders.
Simultaneous treatment with MAO inhibitors, and the period up to 14 days after their withdrawal, hypersensitivity to Paroxetine Hydrochloride.
Angle-closure glaucoma, prostate adenoma, pregnancy and breastfeeding.
Category effects on the fetus by FDA - C.
Stop taking of Paroxetine Hydrochloride should be gradually reducing the dose to avoid withdrawal syndrome, which manifests itself dizziness, nausea, vomiting, insomnia, confusion, increased sweating.
There is contraindicated drinking alcohol during the treatment with Paroxetine Hydrochloride.
Be wary of over 14 days after taking of MAO inhibitors, gradually increasing the dose. MAO inhibitors should not be administered within 2 weeks after complete withdrawal of Paroxetine Hydrochloride.
Simultaneous administration with drugs that inhibit the metabolism of liver enzymes, Paroxetine Hydrochloride should be used in the smallest recommended doses.
In simultaneous use with drugs that induce the metabolism of enzymes it does not required any changes in the initial doses of Paroxetine Hydrochloride.
Be wary of using Paroxetine Hydrochloride with lithium therapy and oral anticoagulants.
There was not found carcinogenic and mutagenic properties of Paroxetine Hydrochloride in experimental studies.
Use Paroxetine Hydrochloride with caution in patients whose activities are connected with the necessity of high concentration of attention and quickness of psychomotor reactions.
Simultaneous administration of Paroxetine Hydrochloride with:
Symptoms: nausea, vomiting, drowsiness, sinus tachycardia, dilated pupils, etc.
Treatment: symptomatic; to remove from the stomach not absorbed part of this drug it is necessary to induce vomiting or gastric lavage.
Depending on the reaction of the Paroxetine Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Paroxetine Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Paroxetine Hydrochloride addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology