Active ingredient: Orphenadrine Citrate

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Orphenadrine Citrate uses


INDICATIONS AND USAGE

Orphenadrine Citrate citrate extended-release tablets, USP are indicated as an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculo skeletal conditions.

CONTRAINDICATIONS

Contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (megaesophagus) and myasthenia gravis.

Contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.

WARNINGS

Some patients may experience transient episodes of light-headedness, dizziness or syncope. Orphenadrine Citrate citrate may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.

PRECAUTIONS

Confusion, anxiety and tremors have been reported in few patients receiving propoxyphene and Orphenadrine Citrate concomitantly. As these symptoms may be simply due to an additive effect, reduction of dosage and/or discontinuation of one or both agents is recommended in such cases.

Orphenadrine Citrate citrate should be used with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias.

Safety of continuous long-term therapy with Orphenadrine Citrate citrate has not been established. Therefore, if Orphenadrine Citrate citrate is prescribed for prolonged use, periodic monitoring of blood, urine and liver function values is recommended.

PREGNANCY

Pregnancy Category C

Animal reproduction studies have not been conducted with Orphenadrine Citrate citrate. It is also not known whether Orphenadrine Citrate citrate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Orphenadrine Citrate citrate should be given to a pregnant woman only if clearly needed.

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PEDIATRIC USE

Safety and effectiveness in pediatric patients have not been established.

ADVERSE REACTIONS

Adverse reactions of Orphenadrine Citrate citrate are mainly due to the mild anti-cholinergic action of Orphenadrine Citrate citrate and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of Orphenadrine Citrate tablets have been reported. No causal relationship has been established.

DRUG ABUSE AND DEPENDENCE

Orphenadrine Citrate citrate has been chronically abused for its euphoric effects.[1] The mood elevating effects may occur at therapeutic doses of Orphenadrine Citrate.[2]

OVERDOSAGE

Orphenadrine Citrate citrate is toxic when overdosed and typically induces anti-cholinergic effects.[3] In a review of Orphenadrine Citrate toxicity, the minimum lethal dose was found to be 2 to 3 grams for adults; however, the range of toxicity is variable and unpredictable.[4] Treatment for Orphenadrine Citrate citrate overdose is evacuation of stomach contents (when necessary), charcoal at repeated doses, intensive monitoring and appropriate supportive treatment of any emergent anti-cholinergic effects.[5]

DOSAGE AND ADMINISTRATION

Adults-Two tablets per day; one in the morning and one in the evening.

HOW SUPPLIED

Product: 68151-1463

NDC: 68151-1463-0 1 TABLET in a PACKAGE

Orphenadrine Citrate Citrate ER 100 mg tabs

Orphenadrine Citrate available forms, composition, doses:


Indications and Usages:

ATC codes:


ICD-10 codes:


Orphenadrine Citrate destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."ORPHENADRINE CITRATE TABLET [CARILION MATERIALS MANAGEMENT]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "orphenadrine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "orphenadrine". http://www.drugbank.ca/drugs/DB0117... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Orphenadrine Citrate?

Depending on the reaction of the Orphenadrine Citrate after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Orphenadrine Citrate not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Orphenadrine Citrate addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Orphenadrine Citrate, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Orphenadrine Citrate consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Visitor reported frequency of use

No survey data has been collected yet

Two visitors reported doses

What is the dose of Orphenadrine Citrate drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
51-100mg1
50.0%
11-50mg1
50.0%

Two visitors reported time for results

What is the time duration Orphenadrine Citrate drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 3 days to notice the result from using Orphenadrine Citrate drug. The time needed to show improvement in health condition after using the medicine Orphenadrine Citrate need not be same for all the users. It varies based on other factors.
Visitors%
3 days1
50.0%
> 3 month1
50.0%

Visitor reported administration

No survey data has been collected yet

One visitor reported age

Visitors%
> 601
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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