Active ingredient: Lorazepam

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Lorazepam uses

Pharmacological action

lorazepam is an anxiolytic drug, a derivative of benzodiazepine. This medication has anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant central, antiemetic effect. The mechanism of the anxiolytic, sedative and hypnotic action is associated with increased inhibitory effect of GABA in the CNS. Anticonvulsant action, apparently in part due to increased presynaptic inhibition; inhibited the spread of epileptogenic activity arising in the epileptogenic foci in the cortex, thalamus and limbic structures, but not removed the excited state of the hearth. Muscle relaxant effect is primarily associated with the suppression of spinal polysynaptic afferent pathways and, presumably, an inhibition of monosynaptic afferent pathways; possibly also a direct inhibitory effect on motor nerves and muscle function.


After oral administration the bioavailability of lorazepam is 95-99%. The plasma proteins binding is about 80%. Vd is 1.3 L / kg. lorazepam is metabolized in the liver by conjugation to form inactive metabolites. T1/2 is 8-15 h. This medicine is derived primarily by the kidneys.

Why is lorazepam prescribed?

Anxiety, sleep disturbances due to anxiety or transient stressful situation, neuroses and neurosis-like states, panic disorder, endogenous psychoses: mania, catatonic state, anxiety and excitement in schizophrenia; acute alcoholic delirium; premedication in anesthesia, epilepsy (in combination therapy), status epilepticus; symptomatic convulsive status; psychosomatic disorders and headaches.

Dosage and administration

For oral administration for adults and adolescents the dose is 0.5-4 mg 1-3 times / day. In IV or IM introduction a single dose is 50 mg / kg, the dose frequency is set depending on the evidence and the clinical situation.

The maximum daily dose when lorazepam administered orally is 10 mg, for IV and IM injections a single dose is 4 mg.


lorazepam side effects, adverse reactions

CNS: rarely - dizziness, ataxia, fatigue, muscle weakness; in some cases - the episodes of amnesia.

Digestive system: rarely - dry mouth, dysphagia, nausea, diarrhea, constipation, appetite disorders; in some cases - liver function abnormalities.

Allergic reactions: rarely - skin rash, itching.

Laboratory parameters: changes in peripheral blood.

Local reactions: for IV injections can be phlebitis or venous thrombosis.

lorazepam contraindications

Myasthenia gravis, angle-closure glaucoma, acute intoxication with psychotropic drugs, acute alcohol intoxication, increased sensitivity to lorazepam.

Using during pregnancy and breastfeeding

During pregnancy, especially in the I trimester, apply lorazepam only under strict indications. lorazepam and / or its metabolites are excreted in breast milk. provision. It should be borne in mind that newborns benzodiazepines metabolized more slowly than adults, therefore it is possible accumulation of the active substance and / or its metabolites in the body of the child.

Special instructions

With extreme caution lorazepam is used in closed-angle glaucoma is suspected, severe chronic obstructive pulmonary disease, in a coma, shock, epilepsy, renal dysfunction, hyperkinesis, hypoproteinemia, severe depression, organic brain disease, porphyria, psychosis with suspected sleep apnea.

The development of adverse reactions are more likely at the beginning of treatment and in cases of exceeding the recommended doses.

With prolonged use of lorazepam may develop addiction and drug dependence.

In the case of using this medication for sedation it may be required reducing the dose of fentanyl derivative used for induction of anesthesia, and it is possible a reduction of time before the mind with induction doses.

Patients receiving lorazepam should refrain from activities in potentially hazardous activities that require attention and psychomotor speed of reaction.

lorazepam drug interactions

When this drug applied simultaneously with:

- drugs which have a depressing effect on the CNS, with alcohol, alcohol containing drugs increased inhibitory effect on the CNS.

- lorazepam and alcohol may develop agitation, aggression, pathological intoxication.

- diminishes the effectiveness of oral contraceptives.

- enhanced effect of depolarizing relaxants.

- nicotine increases the metabolism of lorazepam, and decreases its activity.

- probenecid may interfere with the binding of lorazepam with glucuronic acid, resulting in higher concentrations in blood plasma, and by enhancing the therapeutic effect may develop excessive sedation.

lorazepam in case of emergency / overdose

Symptoms: drowsiness, hypotension, confusion, depression of reflexes, coma.

Treatment: induction of vomiting, gastric lavage, IV introduction of norepinephrine to increase blood pressure, symptomatic therapy, monitoring of vital functions. The introduction of a specific antidote - an antagonist of benzodiazepine receptors flumazenil (in hospital).


Lorazepam available forms, composition, doses:

Apo-Lorazepam 0.5 mg Tablet0.04 USD
Apo-Lorazepam 1 mg Tablet0.05 USD
Apo-Lorazepam 2 mg Tablet0.07 USD
Ativan 0.5 mg Sublingual Tablet0.12 USD
Ativan 0.5 mg tablet1.37 USD
Ativan 1 mg Sublingual Tablet0.15 USD
Ativan 1 mg tablet1.96 USD
Ativan 2 mg Sublingual Tablet0.24 USD
Ativan 2 mg tablet2.3 USD
Ativan 2 mg/ml vial0.9 USD
Ativan 4 mg/ml vial2.16 USD
Concentrate; Oral; Lorazepam 2 mg / ml
Injectable; Injection; Lorazepam 2 mg / ml
Injectable; Injection; Lorazepam 4 mg / ml
LORazepam Intensol 2 mg/ml Concentrate 30ml Bottle44.99 USD
Lorazepam 0.5 mg tablet0.55 USD
Lorazepam 1 mg tablet0.69 USD
Lorazepam 2 mg tablet1.01 USD
Lorazepam 2 mg/ml vial2.5 USD
Lorazepam 4 mg/ml vial9.59 USD
Lorazepam intensol 2 mg/ml1.6 USD
Lorazepam powder20.81 USD
Lorazepam-d5w 100 mg/100 ml1.16 USD
Lorazepam-ns 100 mg/100 ml bag1.16 USD
Lorazepam-ns 60 mg/60 ml bag1.53 USD
Novo-Lorazem 0.5 mg Tablet0.04 USD
Novo-Lorazem 1 mg Tablet0.05 USD
Novo-Lorazem 2 mg Tablet0.07 USD
Pms-Lorazepam 0.5 mg Tablet0.04 USD
Pms-Lorazepam 1 mg Tablet0.05 USD
Pms-Lorazepam 2 mg Tablet0.07 USD
Solution; Oral; Lorazepam 0.5 mg / 5 ml
Tablets, Film-Coated; Oral; Lorazepam 1 mg
Tablets, Film-Coated; Oral; Lorazepam 2.5 mg
Tablets; Oral; Lorazepam 0.5 mg
Tablets; Oral; Lorazepam 1 mg
Tablets; Oral; Lorazepam 2 mg
Tablets; Oral; Lorazepam 2.5 mg


Indications and Usages:

ATC codes:

ICD-10 codes:

Lorazepam destination | category:


Drugs with same active ingredients (Pharmaceutical companies):


  1. Dailymed."LORAZEPAM CONCENTRATE [AMNEAL PHARMACEUTICALS, LLC]". (accessed August 28, 2018).
  2. Dailymed."LORAZEPAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed August 28, 2018).
  3. "lorazepam". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Lorazepam?

Depending on the reaction of the Lorazepam after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Lorazepam not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Lorazepam addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Lorazepam, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Lorazepam consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Lorazepam drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of website users about the frequency of taking the drug Lorazepam is mentioned below.
Once in a day1

Two visitors reported doses

What is the dose of Lorazepam drug you are taking?
According to the survey conducted among website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

Visitor reported time for results

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Visitor reported administration

No survey data has been collected yet

One visitor reported age

> 601

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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