Active ingredient: Ketoprofen

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Ketoprofen uses


Pharmacological action

Ketoprofen is a NSAID, propionic acid derivative. This medication has analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. A pronounced analgesic effect of Ketoprofen is due to two mechanisms: peripheral and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the influence on the biological activity of other neurotrophic substances that play a key role in the release of neurotransmitters in the spinal pain brain). In addition, this drug has anti-bradykinin activity, stabilizes lysosomal membranes, causes a significant inhibition of neutrophils in patients with rheumatoid arthritis.

Pharmacokinetics

After oral and rectal administration Ketoprofen is well absorbed from the gastrointestinal tract. Cmax in plasma by ingestion is achieved through 1-5 hours (depending on dosage form), with rectal administration - after 45-60 min; IM administration - after 20-30 min; IV injections - after 5 minutes.

The plasma protein binding is 99%. Due to the lipophilicity expressed rapidly penetrates the BBB. Css in plasma and cerebrospinal fluid stored between 2 and 18 h.

Ketoprofen well penetrates into synovial fluid, where its concentration is 4 hours after admission exceeds that in plasma.

This medicine is metabolized by binding to glucuronic acid and to a lesser extent by hydroxylation.

Ketoprofen is excreted primarily by kidneys and to a lesser extent through the intestines. T1/2 of Ketoprofen from plasma after oral administration is 1.5-2 h; after rectal administration - about 2 hours; IM administration - 1.27 hours, IV injections - 2 hours.

Why is Ketoprofen prescribed?

Articular syndrome ; symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal (shoulder, artrosinovit, tendonitis, tenosynovitis, bursitis, lumbago), back pain, neuralgia, myalgia. Uncomplicated trauma, particularly sports, sprains, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain. As part of combination therapy of inflammatory diseases of veins, lymphatic vessels, lymph nodes (phlebitis, periflebit, lymphangitis, lymphadenitis surface).

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Dosage and administration

The dosage regimen set individually according to the severity of the disease. For oral administration in adult the initial daily dose is 300 mg in 2-3 doses. For maintenance treatment the dose depends on the dosage form. For the treatment of acute conditions or exacerbations of chronic edema of the process this medication is administered in 100 mg as a single IM injection. Next Ketoprofen administered orally or rectally.

Topically this drug used to the skin surface 2 times / day.

The maximum dose oral or rectal administration is 300 mg / day.

Ketoprofen side effects, adverse reactions

Digestive system: epigastric pain, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, liver, rarely - erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding and perforation.

CNS: headache, dizziness, tinnitus and drowsiness.

Urinary system: kidney damage.

Allergic reactions: skin rash, rarely - bronchospasm.

Local reactions: when Ketoprofen used in rectal suppositories it is possible irritation of the mucous membrane of the rectum, painful defecation, when this medication used in a gel form - itching, skin rash at the site of application.

Ketoprofen contraindications

For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in acute phase, "aspirin triad" expressed by the human liver and / or kidney disease; III trimester of pregnancy; age up of 15 years ; increased sensitivity to Ketoprofen and salicylates.

For rectal administration: proctitis and bleeding from the rectum in history.

For external use: moist dermatitis, eczema, infected abrasions and wounds.

Using during pregnancy and breastfeeding

Ketoprofen is contraindicated for use in the III trimester of pregnancy. In I and II trimesters of pregnancy the use of Ketoprofen may be in cases when the potential benefit to the mother outweighs the potential risk to the fetus.

If necessary to use Ketoprofen in lactating a breast-feeding should be stopped

.Category of the fetus by FDA - C.

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Special instructions

With great caution use Ketoprofen in patients with liver and kidney, gastrointestinal tract diseases in the history of dyspeptic symptoms after major surgery. In the course of treatment it requires systematic monitoring of liver and kidney.

Ketoprofen drug interactions

When this drug applied simultaneously with:

- other NSAIDs increases the risk of erosive and ulcerative lesions of the gastrointestinal tract and bleeding

- antihypertensive drugs it may decreases their actions

- aspirin may decrease the binding of Ketoprofen to plasma proteins and increase its plasma clearance

- heparin, ticlopidine increase risk of bleeding

- lithium therapy - it may increase the concentration of lithium in blood plasma to the toxic by reducing its renal excretion

- diuretics increases the risk of renal failure due to a decrease in renal blood flow caused by inhibition of prostaglandin synthesis, and against the background of hypovolemia

- probenecid it may decreases the clearance of Ketoprofen and its binding to plasma proteins

- methotrexate - may increase the side effects of methotrexate

- warfarin may develop severe, sometimes fatal bleeding.

Ketoprofen in case of emergency / overdose

Symptoms: lethargy, dizziness, nausea, vomiting, epigastric pain - these symptoms are usually reversible. May be respiratory distress, coma, convulsions. Rarely - bleeding from the gastrointestinal tract, hypotension / hypertension, acute renal failure.

Treatment: symptomatic and supportive therapy, monitoring of respiratory and cardiovascular systems. The is no a specific antidote. Hemodialysis is ineffective.

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Ketoprofen available forms, composition, doses:

Price
Apo-Keto 50 mg Capsule0.35 USD
Apo-Keto Sr 200 mg Sustained-Release Tablet1.46 USD
Apo-Keto-E 100 mg Enteric-Coated Tablet0.71 USD
Apo-Keto-E 50 mg Enteric-Coated Tablet0.35 USD
Capsules, Extended Release; Oral; Ketoprofen
Capsules, Extended Release; Oral; Ketoprofen 100 mg
Capsules, Extended Release; Oral; Ketoprofen 150 mg
Capsules, Extended Release; Oral; Ketoprofen 200 mg
Capsules, Retard; Oral; Ketoprofen 100 mg
Capsules, Retard; Oral; Ketoprofen 200 mg
Capsules; Oral; Ketoprofen 25 mg
Capsules; Oral; Ketoprofen 50 mg
Capsules; Oral; Ketoprofen 75 mg
Gel; Topical; Ketoprofen 2.5%
Injectable; Injection; Ketoprofen 10%
Injectable; Injection; Ketoprofen 50 mg / ml
Ketoprofen 50 mg capsule1.0 USD
Ketoprofen 75 mg capsule1.12 USD
Ketoprofen CR 200 mg 24 Hour Capsule2.8 USD
Ketoprofen micronized powder3.84 USD
Ketoprofen powder43.74 USD
Orudis 75 mg capsule1.58 USD
Orudis kt 12.5 mg tablet0.3 USD
Pms-Ketoprofen 100 mg Suppository1.1 USD
Suppositories; Rectal; Ketoprofen 100 mg
Tablets, Enteric Coated; Oral; Ketoprofen
Tablets, Extended Release; Oral; Ketoprofen
Tablets, Film-Coated; Oral; Ketoprofen 100 mg
Tablets, Film-Coated; Oral; Ketoprofen 50 mg
Tablets; Oral; Ketoprofen 100 mg
Tablets; Oral; Ketoprofen 12.5 mg

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Indications and Usages:

ATC codes:


ICD-10 codes:


Ketoprofen destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."KETOPROFEN CAPSULE [A-S MEDICATION SOLUTIONS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."KETOPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "ketoprofen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Ketoprofen?

Depending on the reaction of the Ketoprofen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ketoprofen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Ketoprofen addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Ketoprofen, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ketoprofen consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Ketoprofen useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Visitor reported frequency of use

No survey data has been collected yet

Three visitors reported doses

What is the dose of Ketoprofen drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
1-5mg1
33.3%
51-100mg1
33.3%
11-50mg1
33.3%

Visitor reported time for results

No survey data has been collected yet

One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Ketoprofen drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
With a meal1
100.0%

One visitor reported age

Visitors%
46-601
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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