Active ingredient: Gabapentin

Rating: 3.75 - 4 review(s)
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Gabapentin uses


Pharmacological action

Gabapentin is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Gabapentin is different from other anticonvulsants acting through GABA synapses. In in vitro studies showed that Gabapentin is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Gabapentin and its derivatives. Gabapentin in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.

The final mechanism of action of Gabapentin is not defined.

Pharmacokinetics

Gabapentin is absorbed from the gastrointestinal tract. After oral administration of Gabapentin Cmax in plasma achieved within 2-3 hours. The absolute bioavailability of approximately 60%. Taking of this medication in conjunction with food (including a high-fat) does not affect the pharmacokinetics of Gabapentin.

Gabapentin is not bound to plasma proteins and has Vd 57.7 l.

Gabapentin is excreted only by the kidneys. Signs of biotransformation of Gabapentin in the human body were not found.

Gabapentin is removed from plasma by hemodialysis.

The concentrations of Gabapentin in the plasma of children were similar to those of adults.

Why is Gabapentin prescribed?

Treatment of neuropathic pain in adults over the age of 18 years; monotherapy of partial seizures with secondary generalization and without its fot children and adults older than 12 years; as an adjunct in the treatment of partial seizures with secondary generalization and without its for adults and children aged 3 years and older.

Dosage and administration

Dosing regimen of Gabapentin is individual, depending on the indications and treatment regimens.

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Gabapentin side effects, adverse reactions

CNS and peripheral nervous system: amnesia, ataxia, confusion, impaired coordination, depression, dizziness, dysarthria, nervous hyperexcitability, nystagmus, drowsiness, impaired thinking, tremor, muscle cramps, amblyopia, diplopia, hyperkinesia, strengthening, weakening or absence of reflexes, paresthesia, anxiety, hostility, impaired gait.

Digestive system: change in staining of teeth, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests.

Hemopoietic system: leucopenia, decrease the number of leukocytes, thrombocytopenic purpura.

Respiratory system: rhinitis, pharyngitis, cough, pneumonia.

Musculoskeletal system: myalgia, arthralgia, bone fractures.

Cardiovascular: hypertension, manifestations of vasodilation.

Urinary system: urinary tract infections, urinary incontinence.

Allergic reactions: erythema multiforme, Stevens-Johnson syndrome.

Dermatological reactions: maceration of the skin, acne, itching, rash.

Other: back pain, fatigue, peripheral edema, impotence, fatigue, malaise, swelling of the face, increase in body weight, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose in children - a viral infection, otitis media.

Gabapentin contraindications

Hypersensitivity to Gabapentin.

Using during pregnancy and breastfeeding

Adequate and well-controlled studies on the safety of Gabapentin during pregnancy and lactation in humans has not been conducted. If necessary use Gabapentin during pregnancy and lactation patients should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or infant.

Gabapentin is excreted in breast milk. When this drug used in the lactation period, the character of the action of Gabapentin on the infant is not defined.

Category effects on the fetus by FDA - C.

Special instructions

Abrupt discontinuation of therapy by anticonvulsant drugs in patients with partial seizures may provoke a convulsive status. If necessary to reduce the dose of Gabapentin, to cancel or replace it with an alternative means it should be phased over a minimum of 1 week.

Gabapentin is not an effective drug for treatment of absence seizures.

For patients with impaired renal function and patients in hemodialysis it requires correction of dosing regimen. Elderly patients may require correction of the dosing regimen of Gabapentin due to the fact that such patients may decrease renal clearance.

The efficacy and safety of neuropathic pain treatment in patients under age 18 is not defined.

During the period of treatment it is necessary to avoid taking alcohol.

Prior to determining individual response to treatment the patient should refrain from potentially dangerous activities coupled with the need to focus and improve the speed of psychomotor reactions.

Gabapentin drug interactions

Simultaneous administration of Gabapentin with:

  • antacids reduces the absorption of Gabapentin from the gastrointestinal tract.
  • felbamate may increase its T1/2.
  • described a case of increasing the concentration of phenytoin in blood plasma.

    Gabapentin in case of emergency / overdose

    There was reported an acute overdose while taking 49 g of Gabapentin. Symptoms: double vision, slurred speech, drowsiness, lethargy, diarrhea.

    Treatment: maintenance therapy, hemodialysis.

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    Gabapentin available forms, composition, doses:

    Price
    Apo-Gabapentin 100 mg Capsule0.26 USD
    Apo-Gabapentin 300 mg Capsule0.64 USD
    Apo-Gabapentin 400 mg Capsule0.76 USD
    Capsules; Oral; Gabapentin 100 mg
    Capsules; Oral; Gabapentin 300 mg
    Capsules; Oral; Gabapentin 400 mg
    Co Gabapentin 100 mg Capsule0.26 USD
    Co Gabapentin 300 mg Capsule0.64 USD
    Co Gabapentin 400 mg Capsule0.76 USD
    Gabapentin 100 mg Capsule0.41 USD
    Gabapentin 100 mg tablet0.53 USD
    Gabapentin 300 mg Capsule1.02 USD
    Gabapentin 300 mg tablet1.32 USD
    Gabapentin 400 mg Capsule1.21 USD
    Gabapentin 400 mg tablet1.59 USD
    Gabapentin 600 mg tablet2.58 USD
    Gabapentin 800 mg tablet3.09 USD
    Gabapentin powder30.0 USD
    Mylan-Gabapentin 100 mg Capsule0.26 USD
    Mylan-Gabapentin 300 mg Capsule0.64 USD
    Mylan-Gabapentin 400 mg Capsule0.76 USD
    Neurontin 100 mg Capsule0.65 USD
    Neurontin 250 mg/5ml Solution0.32 USD
    Neurontin 300 mg Capsule1.67 USD
    Neurontin 400 mg Capsule1.97 USD
    Neurontin 600 mg tablet3.94 USD
    Neurontin 800 mg tablet4.73 USD
    Novo-Gabapentin 100 mg Capsule0.26 USD
    Novo-Gabapentin 300 mg Capsule0.64 USD
    Novo-Gabapentin 400 mg Capsule0.76 USD
    Phl-Gabapentin 100 mg Capsule0.26 USD
    Phl-Gabapentin 300 mg Capsule0.64 USD
    Phl-Gabapentin 400 mg Capsule0.76 USD
    Pms-Gabapentin 100 mg Capsule0.26 USD
    Pms-Gabapentin 300 mg Capsule0.64 USD
    Pms-Gabapentin 400 mg Capsule0.76 USD
    Ran-Gabapentin 100 mg Capsule0.26 USD
    Ran-Gabapentin 300 mg Capsule0.64 USD
    Ran-Gabapentin 400 mg Capsule0.76 USD
    Ratio-Gabapentin 100 mg Capsule0.26 USD
    Ratio-Gabapentin 300 mg Capsule0.64 USD
    Ratio-Gabapentin 400 mg Capsule0.76 USD
    Solution; Oral; Gabapentin 250 mg / 5 ml
    Tablets, Film-Coated; Oral; Gabapentin 600 mg
    Tablets, Film-Coated; Oral; Gabapentin 800 mg
    Tablets; Oral; Gabapentin 100 mg
    Tablets; Oral; Gabapentin 300 mg
    Tablets; Oral; Gabapentin 400 mg
    Tablets; Oral; Gabapentin 600 mg
    Tablets; Oral; Gabapentin 800 mg

    Indications and Usages:

    ATC codes:


    ICD-10 codes:


    Gabapentin destination | category:


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    Drugs with same active ingredients (Pharmaceutical companies):


    References

    1. Dailymed."GABAPENTIN TABLET, FILM COATED [LAKE ERIE MEDICAL & SURGICAL S6758UPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."GABAPENTIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. "gabapentin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Gabapentin?

    Depending on the reaction of the Gabapentin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Gabapentin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Gabapentin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Gabapentin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Gabapentin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug Gabapentin useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Useful1
    100.0%

    Two visitors reported side effects

    Did you get side effects while taking the Gabapentin drug, or were there no side effects?
    According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Gabapentin medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
    Visitors%
    It has side effects1
    50.0%
    No side effects1
    50.0%

    One visitor reported price estimates

    What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
    The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Gabapentin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
    Visitors%
    Not expensive1
    100.0%

    Three visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Gabapentin drug as prescribed by the doctor?

    Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Gabapentin is mentioned below.
    Visitors%
    Twice in a day2
    66.7%
    3 times in a day1
    33.3%

    Five visitors reported doses

    What is the dose of Gabapentin drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    201-500mg3
    60.0%
    101-200mg1
    20.0%
    501mg-1g1
    20.0%

    Visitor reported time for results

    No survey data has been collected yet

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Gabapentin drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    After food1
    100.0%

    Two visitors reported age

    Visitors%
    > 601
    50.0%
    16-291
    50.0%

    Visitor reviews


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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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