Active ingredient: Fluoxetine

When are you taking this medicine?

Fluoxetine uses

Pharmacological action

fluoxetine is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. fluoxetine is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants fluoxetine apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. fluoxetine does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.


fluoxetine absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. fluoxetine easily penetrates through the BBB.

fluoxetine metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

T1/2 of fluoxetine is 2-3 days, norfluoxetine - 7-9 days.

Why is fluoxetine prescribed?

Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage and administration

The initial dose of fluoxetine is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

The maximum oral daily dose for adults is 80 mg.

fluoxetine side effects, adverse reactions

CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

Digestive system: diarrhea, nausea.

Metabolism: increased sweating, hypoglycemia, hyponatremia.

Reproductive system: decreased libido.

Allergic reactions: skin rash, itching.

Other: pain in joints and muscles, shortness of breath, increased body temperature.


fluoxetine contraindications

Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to fluoxetine.

Using during pregnancy and breastfeeding

fluoxetine is contraindicated during pregnancy and lactation.

Special instructions

fluoxetine should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with fluoxetine increases the risk of epileptic seizures.

With the simultaneous application of fluoxetine and electroconvulsive therapy may develop prolonged seizures.

fluoxetine can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of fluoxetine before therapy MAO inhibitors should not be less than 5 weeks.

Elderly patients need correction of dosing regimen.

Safety of fluoxetine in children has not been established.

During the period of treatment it needed to avoid use alcohol.

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

fluoxetine drug interactions

Simultaneous administration of fluoxetine with:

  • drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
  • MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome ;
  • fluoxetine inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
  • it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
  • hypoglycemic agents may increase their activities;
  • haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
  • with lithium salts may increase or decrease the concentration of lithium in blood plasma;
  • may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of fluoxetine Sanis Health);
  • propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
  • may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with fluoxetine.

    fluoxetine in case of emergency / overdose

    Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of fluoxetine (in combination with maprotiline, codeine, temazepam).

    Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.


    Fluoxetine available forms, composition, doses:

    Apo-Fluoxetine 10 mg Capsule1.13 USD
    Apo-Fluoxetine 20 mg Capsule1.06 USD
    Apo-Fluoxetine 4 mg/ml Liquid0.61 USD
    Capsules, Delayed Release; Oral; Fluoxetine Hydrochloride 90 mg
    Capsules; Oral; Fluoxetine Hydrochloride 10 mg
    Capsules; Oral; Fluoxetine Hydrochloride 20 mg
    Capsules; Oral; Fluoxetine Hydrochloride 40 mg
    Co Fluoxetine 10 mg Capsule1.13 USD
    Co Fluoxetine 20 mg Capsule1.06 USD
    FLUoxetine HCl 10 mg capsule2.7 USD
    FLUoxetine HCl 20 mg capsule2.77 USD
    FLUoxetine HCl 20 mg/5ml Solution1.03 USD
    FLUoxetine HCl 40 mg capsule5.54 USD
    Fluoxetine hcl 10 mg tablet2.72 USD
    Fluoxetine hcl 20 mg tablet4.26 USD
    Fluoxetine hcl powder8.32 USD
    Fxt 40 40 mg Capsule2.3 USD
    Mylan-Fluoxetine 10 mg Capsule1.13 USD
    Mylan-Fluoxetine 20 mg Capsule1.06 USD
    Novo-Fluoxetine 10 mg Capsule1.13 USD
    Novo-Fluoxetine 20 mg Capsule1.06 USD
    Nu-Fluoxetine 10 mg Capsule1.13 USD
    Nu-Fluoxetine 20 mg Capsule1.06 USD
    PROzac 10 mg capsule2.02 USD
    PROzac 10 mg tablet4.31 USD
    PROzac 20 mg capsule2.02 USD
    PROzac 20 mg/5ml Solution 120ml Bottle266.51 USD
    PROzac 40 mg capsule13.89 USD
    PROzac Weekly 1 Package = 4 capsule (90 mg) Disp Pack140.77 USD
    Phl-Fluoxetine 10 mg Capsule1.13 USD
    Phl-Fluoxetine 20 mg Capsule1.06 USD
    Pms-Fluoxetine 10 mg Capsule1.13 USD
    Pms-Fluoxetine 20 mg Capsule1.06 USD
    Prozac weekly 90 mg capsule34.5 USD
    Rapiflux 20 mg tablet3.11 USD
    Ratio-Fluoxetine Hydrochloride 10 mg Capsule1.13 USD
    Ratio-Fluoxetine Hydrochloride 20 mg Capsule1.06 USD
    Sandoz Fluoxetine 20 mg Capsule1.06 USD
    Sandoz Fluoxetine 10 mg Capsule1.13 USD
    Sarafem 10 mg tablet7.91 USD
    Sarafem 15 mg tablet7.91 USD
    Sarafem 20 mg tablet7.91 USD
    Sarafem 7 10 mg tablet Box61.08 USD
    Sarafem 7 20 mg tablet Each Box Contains 7 tablet59.55 USD
    Solution; Oral; 20 mg / 5 ml
    Solution; Oral; Fluoxetine Hydrochloride 20 mg / 5 ml
    Tablets, Dispersible; Oral; Fluoxetine Hydrochloride 20 mg
    Tablets; Oral; Fluoxetine Hydrochloride 10 mg
    Tablets; Oral; Fluoxetine Hydrochloride 20 mg
    Tablets; Oral; Fluoxetine Hydrochloride 40 mg

    Indications and Usages:

    ATC codes:

    ICD-10 codes:

    Fluoxetine destination | category:


    Drugs with same active ingredients (Pharmaceutical companies):


    2. "fluoxetine". (accessed August 28, 2018).
    3. "fluoxetine". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Fluoxetine?

    Depending on the reaction of the Fluoxetine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fluoxetine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Fluoxetine addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Fluoxetine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Fluoxetine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    Two visitors reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Fluoxetine drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of website users about the frequency of taking the drug Fluoxetine is mentioned below.
    Once in a day2

    Visitor reported doses

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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