Active ingredient: Doxycycline Hydrochloride

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Doxycycline Hydrochloride uses


Pharmacological action

Doxycycline Hydrochloride is an semisynthetic tetracycline group's antibiotic of broad-spectrum. This medication has bacteriostatic action due to suppression of protein synthesis of pathogens. It active against aerobic gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.

Doxycycline Hydrochloride is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.

Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis are resistant to Doxycycline Hydrochloride.

Pharmacokinetics

After oral administration Doxycycline Hydrochloride is quickly and almost completely absorbed from the gastrointestinal tract. Ingestion has very little effect on the absorption of Doxycycline Hydrochloride. This medication is widely distributed in tissues and body fluids. Plasma protein binding is 80-95%. T1/2 is 12-22 h. Doxycycline Hydrochloride excreted in the urine as unchanged (40%) but the main part of the dose excreted unchanged in the feces through bile secretion.

Why is Doxycycline Hydrochloride prescribed?

Infectious-inflammatory diseases caused by microorganisms sensitive to Doxycycline Hydrochloride including infections of the respiratory and ENT organs; gastrointestinal tract infections; purulent infections of skin and soft tissues ; infection of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.

Dosage and administration

Doxycycline Hydrochloride is indicated for adults orally or IV (infusions) in 200 mg / day dosess on the first day of treatment, in the coming days at 100-200 mg / day. Multiplicity of admission (or IV infusion) is 1-2 times / day. For children older than 8 years of age and weighing over 50 kg the daily Doxycycline Hydrochloride dose for oral administration or IV (infusion) in the first day of treatment is 4 mg / kg. In next days ir is 2-4 mg / kg depending on the severity of the clinical course of disease. Multiplicity of admission (or intravenous infusion) is 1-2 times / day. The recommended minimum time for IV infusion 100 mg of Doxycycline Hydrochloride (a concentration of infusion solution is 0.5 mg / ml) is 1 hour.

Maximum doses: for adults for oral administration is 300 mg / day or 600 mg / day (depending on the etiology of the agent); for iv injection it is 300 mg / day.

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Doxycycline Hydrochloride side effects, adverse reactions

Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in the blood of hepatic transaminases, alkaline phosphatase, bilirubin.

Hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.

Allergic reactions: skin rash, itching, eosinophilia, rarely - angioedema, photosensitivity.

Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.

Doxycycline Hydrochloride contraindications

Pregnancy, children age up to 8 years, hypersensitivity to tetracyclines, porphyria, severe liver insufficiency, leukopenia, lactation period, myasthenia (for IV administration).

Using during pregnancy and breastfeeding

Doxycycline Hydrochloride is contraindicated during pregnancy and lactation. Doxycycline Hydrochloride crosses the placental barrier. This medication may cause long-term discoloration of the teeth, enamel hypoplasia, inhibition of growth of bones of the fetus and also the development of fatty liver.

If necessary using during lactation patients should stop breastfeeding.

Special instructions

With careful use of Doxycycline Hydrochloride with impaired liver function. If a patient has renal impairment the dose adjustment is not required.

To prevent local irritating action Doxycycline Hydrochloride should be taken during the day with plenty of fluids, food or milk. Due to possible development of photosensitivity it is necessary the restriction of insolation during treatment and for 4-5 days thereafter.

Doxycycline Hydrochloride is not used in children younger than 8 years because tetracyclines (including Doxycycline Hydrochloride) are causing long-term discoloration of the teeth, enamel hypoplasia and retardation of longitudinal growth of bones in these patients.

Doxycycline Hydrochloride solution for IV administration should be used no later than 72 hours after its preparation.

Doxycycline Hydrochloride drug interactions

Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxycycline Hydrochloride, in connection with what it is necessary to avoid their simultaneous use.

It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxycycline Hydrochloride).

Absorption of Doxycycline Hydrochloride is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).

Due to suppression of intestinal microflora Doxycycline Hydrochloride reduces prothrombin index which requires dose adjustment of indirect anticoagulants.

Doxycycline Hydrochloride reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.

Simultaneous administration of Doxycycline Hydrochloride with:

  • barbiturates, carbamazepine, phenytoin concentrations of Doxycycline Hydrochloride in plasma decreases due to the induction of liver enzymes, which may be responsible for the decrease of its antibacterial action.
  • retinol improves intracranial pressure.

    Doxycycline Hydrochloride in case of emergency / overdose

    Treatment: discontinuation, symptomatic and supportive therapy. Hemodialysis is ineffective.

    Doxycycline Hydrochloride available forms, composition, doses:


    Indications and Usages:

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    Doxycycline Hydrochloride destination | category:


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    Drugs with same active ingredients (Pharmaceutical companies):


    References

    1. Dailymed."DOXYCYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "doxycycline". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "doxycycline". http://www.drugbank.ca/drugs/DB0025... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Doxycycline Hydrochloride?

    Depending on the reaction of the Doxycycline Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Doxycycline Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Doxycycline Hydrochloride addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Doxycycline Hydrochloride, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Doxycycline Hydrochloride consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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