Active ingredient: Doxycycline Hyclate

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When are you taking this medicine?

Doxycycline Hyclate uses


Pharmacological action

Doxycycline Hyclate is an semisynthetic tetracycline group's antibiotic of broad-spectrum. This medication has bacteriostatic action due to suppression of protein synthesis of pathogens. It active against aerobic gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.

Doxycycline Hyclate is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Mycoplasma spp. and Chlamydia spp.

Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis are resistant to Doxycycline Hyclate.

Pharmacokinetics

After oral administration Doxycycline Hyclate is quickly and almost completely absorbed from the gastrointestinal tract. Ingestion has very little effect on the absorption of Doxycycline Hyclate. This medication is widely distributed in tissues and body fluids. Plasma protein binding is 80-95%. T1/2 is 12-22 h. Doxycycline Hyclate excreted in the urine as unchanged (40%) but the main part of the dose excreted unchanged in the feces through bile secretion.

Why is Doxycycline Hyclate prescribed?

Infectious-inflammatory diseases caused by microorganisms sensitive to Doxycycline Hyclate including infections of the respiratory and ENT organs; gastrointestinal tract infections; purulent infections of skin and soft tissues ; infection of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsiosis, osteomyelitis, trachoma, chlamydia.

Dosage and administration

Doxycycline Hyclate is indicated for adults orally or IV (infusions) in 200 mg / day dosess on the first day of treatment, in the coming days at 100-200 mg / day. Multiplicity of admission (or IV infusion) is 1-2 times / day. For children older than 8 years of age and weighing over 50 kg the daily Doxycycline Hyclate dose for oral administration or IV (infusion) in the first day of treatment is 4 mg / kg. In next days ir is 2-4 mg / kg depending on the severity of the clinical course of disease. Multiplicity of admission (or intravenous infusion) is 1-2 times / day. The recommended minimum time for IV infusion 100 mg of Doxycycline Hyclate (a concentration of infusion solution is 0.5 mg / ml) is 1 hour.

Maximum doses: for adults for oral administration is 300 mg / day or 600 mg / day (depending on the etiology of the agent); for iv injection it is 300 mg / day.

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Doxycycline Hyclate side effects, adverse reactions

Digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, transient increase in the blood of hepatic transaminases, alkaline phosphatase, bilirubin.

Hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.

Allergic reactions: skin rash, itching, eosinophilia, rarely - angioedema, photosensitivity.

Other: increased residual nitrogen, candidiasis, intestinal dysbiosis, discoloration of teeth in children.

Doxycycline Hyclate contraindications

Pregnancy, children age up to 8 years, hypersensitivity to tetracyclines, porphyria, severe liver insufficiency, leukopenia, lactation period, myasthenia (for IV administration).

Using during pregnancy and breastfeeding

Doxycycline Hyclate is contraindicated during pregnancy and lactation. Doxycycline Hyclate crosses the placental barrier. This medication may cause long-term discoloration of the teeth, enamel hypoplasia, inhibition of growth of bones of the fetus and also the development of fatty liver.

If necessary using during lactation patients should stop breastfeeding.

Special instructions

With careful use of Doxycycline Hyclate with impaired liver function. If a patient has renal impairment the dose adjustment is not required.

To prevent local irritating action Doxycycline Hyclate should be taken during the day with plenty of fluids, food or milk. Due to possible development of photosensitivity it is necessary the restriction of insolation during treatment and for 4-5 days thereafter.

Doxycycline Hyclate is not used in children younger than 8 years because tetracyclines (including Doxycycline Hyclate) are causing long-term discoloration of the teeth, enamel hypoplasia and retardation of longitudinal growth of bones in these patients.

Doxycycline Hyclate solution for IV administration should be used no later than 72 hours after its preparation.

Doxycycline Hyclate drug interactions

Medications containing metal ions (antacids, products containing iron, magnesium, calcium) form inactive chelates with Doxycycline Hyclate, in connection with what it is necessary to avoid their simultaneous use.

It needed to avoid combination with penicillins, cephalosporins, bactericidal action and is an antagonist of bacteriostatic antibiotics (including Doxycycline Hyclate).

Absorption of Doxycycline Hyclate is reduced by cholestyramine and colestipol (observe the interval between the reception of at least 3 h).

Due to suppression of intestinal microflora Doxycycline Hyclate reduces prothrombin index which requires dose adjustment of indirect anticoagulants.

Doxycycline Hyclate reduces the reliability of contraception and increases the frequency of breakthrough bleeding while taking estrogen-containing oral contraceptives.

Simultaneous administration of Doxycycline Hyclate with:

  • barbiturates, carbamazepine, phenytoin concentrations of Doxycycline Hyclate in plasma decreases due to the induction of liver enzymes, which may be responsible for the decrease of its antibacterial action.
  • retinol improves intracranial pressure.

    Doxycycline Hyclate in case of emergency / overdose

    Treatment: discontinuation, symptomatic and supportive therapy. Hemodialysis is ineffective.

    Doxycycline Hyclate available forms, composition, doses:


    Indications and Usages:

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    Doxycycline Hyclate destination | category:


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    Drugs with same active ingredients (Pharmaceutical companies):


    References

    1. Dailymed."DOXYCYCLINE HYCLATE CAPSULE, GELATIN COATED [WEST-WARD PHARMACEUTICALS CORP]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Doxycycline Hyclate?

    Depending on the reaction of the Doxycycline Hyclate after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Doxycycline Hyclate not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Doxycycline Hyclate addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Doxycycline Hyclate, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Doxycycline Hyclate consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

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    Visitor reported price estimates

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    Visitor reported frequency of use

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    One visitor reported doses

    What is the dose of Doxycycline Hyclate drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    51-100mg1
    100.0%

    One visitor reported time for results

    What is the time duration Doxycycline Hyclate drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Doxycycline Hyclate drug. The time needed to show improvement in health condition after using the medicine Doxycycline Hyclate need not be same for all the users. It varies based on other factors.
    Visitors%
    1 day1
    100.0%

    Visitor reported administration

    No survey data has been collected yet

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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