Active ingredient: Diphenhydramine

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Diphenhydramine uses

Pharmacological action

diphenhydramine Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.

When diphenhydramine Xepa-Soul Pattinson administered orally diphenhydramine has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.

When applied externally it has antiallergic effect.


diphenhydramine Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is achieved after 20-40 min. Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).

Why is diphenhydramine Xepa-Soul Pattinson prescribed?

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.

Dosage and administration

Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of diphenhydramine Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.

diphenhydramine Xepa-Soul Pattinson side effects, adverse reactions

Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.

Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.


diphenhydramine Xepa-Soul Pattinson contraindications

Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to diphenhydramine.

Using during pregnancy and breastfeeding

During pregnancy and lactation, diphenhydramine used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

Special instructions

With careful use diphenhydramine during pregnancy and lactation.

During the period of treatment with diphenhydramine Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.

Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.

Precautionary measures

diphenhydramine Xepa-Soul Pattinson is not recommended for SC injection. Since diphenhydramine has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history, increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with diphenhydramine should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.

diphenhydramine Xepa-Soul Pattinson drug interactions

When diphenhydramine Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.

With simultaneous use of diphenhydramine Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of diphenhydramine.

The antagonistic interaction observed with a joint appointment with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.

diphenhydramine Xepa-Soul Pattinson in case of emergency / overdose

Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.

Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.


Diphenhydramine available forms, composition, doses:

Allergy 25 mg tablet0.14 USD
Banophen 25 mg tablet0.08 USD
Banophen allergy liquid0.02 USD
Banophen anti-itch 2% cream0.16 USD
Benadryl 2% spray0.09 USD
Benadryl 25 mg kapseals0.14 USD
Benadryl 50 mg/ml vial1.36 USD
Benadryl allergy 25 mg kapgels0.15 USD
Benadryl allergy 25 mg softgel0.19 USD
Benadryl allergy 25 mg strips0.45 USD
Benadryl allergy 25 mg ultratab0.19 USD
Benadryl allergy fastmelt tablet0.26 USD
Benadryl allergy-cold kapgels0.19 USD
Benadryl allergy-sinus caplet0.22 USD
Benadryl allergy-sinus kapgels0.19 USD
Benadryl anti-itch 0.45% gel0.05 USD
Benadryl itch relief stick0.16 USD
Benadryl itch stopping crm0.14 USD
Benadryl itch stopping gel0.04 USD
Benadryl-d allergy-sinus ultratab0.19 USD
CVS Pharmacy allergy 25 mg caplet0.07 USD
CVS Pharmacy allergy 25 mg tablet0.11 USD
CVS Pharmacy itch relief spray0.06 USD
Capsules; Oral; Diphenhydramine Hydrochloride 25 mg
Capsules; Oral; Diphenhydramine Hydrochloride 50 mg
Child benadryl-d aller-sin liquid0.04 USD
Compoz 25 mg gelcap0.2 USD
Compoz 50 mg tablet0.27 USD
Diphen 25 mg capsule0.06 USD
Diphenhist 25 mg caplet0.06 USD
Diphenhist 50 mg tablet0.09 USD
Diphenhist with zinc cream0.12 USD
DiphenhydrAMINE HCl 100 50 mg capsule Bottle13.99 USD
DiphenhydrAMINE HCl 25 mg capsule0.13 USD
DiphenhydrAMINE HCl 50 mg/ml vial1.44 USD
Diphenhydramine 25 mg capsule0.04 USD
Diphenhydramine 25 mg minitab0.11 USD
Diphenhydramine 25 mg tablet0.02 USD
Diphenhydramine 50 mg caplet0.05 USD
Diphenhydramine 50 mg capsule0.1 USD
Diphenhydramine 50 mg/ml3.94 USD
Diphenhydramine 50 mg/ml vial1.69 USD
Diphenhydramine hcl powder0.17 USD
Diphenmax 25 mg tablet1.24 USD
Dytan 25 mg tablet chewable1.37 USD
Elixir; Oral; Diphenhydramine Hydrochloride 12.5 mg / 5 ml
Eql allergy 25 mg tablet0.17 USD
Genahist 25 mg tablet0.09 USD
Injectable; Injection; Diphenhydramine Hydrochloride 10 mg / ml
Injectable; Injection; Diphenhydramine Hydrochloride 50 mg / ml
Nighttime sleep aid 25 mg caplet0.07 USD
Nighttime sleep aid 25 mg cplt0.17 USD
Nytol 25 mg tablet0.23 USD
Ra allergy 25 mg tablet0.12 USD
Ra anti-tussive dm syrup0.02 USD
Ra sleep tablet0.09 USD
Siladryl 12.5 mg/5 ml liquid0.02 USD
Silphen cough syrup0.02 USD
Silphen dm cough syrup0.02 USD
Simply sleep 25 mg caplet0.11 USD
Sleep ii tablet0.11 USD
Sleep-eze 3 tablet0.29 USD
Solution; Oral; Diphenhydramine Hydrochloride 10 mg / 5 ml
Solution; Oral; Diphenhydramine Hydrochloride 5 mg / 5 ml
Sominex 25 mg tablet0.16 USD
Sominex max str 50 mg caplet0.27 USD
Syrup; Oral; Diphenhydramine Hydrochloride 10 mg / 5 ml
Syrup; Oral; Diphenhydramine Hydrochloride 12.5 mg / 5 ml
Tablets; Oral; Diphenhydramine Hydrochloride 25 mg
Tablets; Oral; Diphenhydramine Hydrochloride 50 mg
Unisom 25 mg sleeptabs0.25 USD
Unisom 50 mg sleepgels0.25 USD
Unisom sleep aid tablet0.34 USD
Unisom sleepmelts 25 mg tablet0.24 USD
Vicks 44d cough & head liquid0.03 USD
Vicks 44e cough & chest liquid0.03 USD
Wal-dryl anti-itch spray0.08 USD


Indications and Usages:

ATC codes:

ICD-10 codes:

Diphenhydramine destination | category:


Drugs with same active ingredients (Pharmaceutical companies):


  1. "diphenhydramine". (accessed August 28, 2018).
  2. "diphenhydramine". (accessed August 28, 2018).
  3. "8GTS82S83M: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Diphenhydramine?

Depending on the reaction of the Diphenhydramine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Diphenhydramine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Diphenhydramine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Diphenhydramine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Diphenhydramine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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What is the dose of Diphenhydramine drug you are taking?
According to the survey conducted among website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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