Active ingredient: Cloxacillin

Rating: 5 - 1 review(s)
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Cloxacillin uses



NADA 055-058, Approved by FDA

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description:

cloxacillin (cloxacillin benzathine) for Intramammary Infusion into the Dry Cow is a product which provides bactericidal activity against gram-positive bacteria. The active agent, cloxacillin benzathine, is a sparingly soluble salt of the semisynthetic penicillin, cloxacillin. cloxacillin is a derivative of 6-aminopenicillanic acid, and therefore is chemically related to other penicillins. It has, however, the antibacterial properties described below, which distinguish it from certain other penicillins.

Each 10 mL disposable syringe contains cloxacillin benzathine equivalent to 500 mg of cloxacillin activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.

Storage:

Do not store above 25°C (77°F). Do not freeze.

Action:

In the non-lactating mammary gland, cloxacillin (cloxacillin benzathine) provides bactericidal levels of the active antibiotic, cloxacillin, for a prolonged period of time. This prolonged activity is due to the low solubility of the cloxacillin benzathine and to the slow-release oil-gel base. This prolonged contact between the antibiotic and the pathogenic organism enhances the probability of a bacteriological cure.

cloxacillin is not destroyed by the enzyme, penicillinase, and therefore, is active against penicillin-resistant strains of Staphylococcus aureus. It is also active against non-penicillinase-producing Staphylococcus aureus as well as Streptococcus agalactiae.

The class disc, Methicillin 5 mcg, should be used to estimate the in vitro susceptibility of bacteria to cloxacillin.

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Indications:

For the treatment of mastitis in dairy cows during the dry period.

cloxacillin has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus including penicillin-resistant strains.

Treatment of the dry cow with cloxacillin is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated attacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms.

Dosage for Dry Cows:

Infuse the contents of one syringe (10 mL) into each quarter following the last milking. See Directions for Use.

Directions for Use:

cloxacillin (cloxacillin benzathine) is for use in dry cows only. Administer immediately after the last milking. Use no later than 30 days prior to calving.

Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.

cloxacillin is packaged with the Opti-Sert® Protective Cap.

For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3–4 mm of the syringe tip.

For full insertion: Remove protective cap to expose the full length of the syringe tip.

Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.

Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.

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Precautions:

Because it is a derivative of 6-aminopenicillanic acid, cloxacillin has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.

Residue Warnings:

1. For use in dry cows only.

2. Not to be used within 30 days of calving.

3. Any animal infused with this product must not be slaughtered for food until 30 days after the latest infusion.

How Supplied:

cloxacillin (cloxacillin benzathine) Intramammary Infusion is supplied as 10 mL syringes containing 500 mg of cloxacillin activity per syringe. One display carton contains 12 syringes. One pail contains 144 syringes.

NDC 0010-4720-01 - 10 mL syringe

NDC 0010-4720-02 - 12 syringes

NDC 0010-4720-03 - 144 syringes

Opti-Sert is a registered trademark of Zoetis W LLC - used under license.

cloxacillin is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.

© 2014 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.

Made in Italy

Manufactured for:

Boehringer Ingelheim Vetmedica, Inc.

St. Joseph, MO 64506 U.S.A.

51729292

472001-03

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Cloxacillin available forms, composition, doses:

Price
Apo-Cloxi 25 mg/ml Liquid0.05 USD
Apo-Cloxi 250 mg Capsule0.19 USD
Apo-Cloxi 500 mg Capsule0.38 USD
Capsules; Oral; Cloxacillin Sodium 250 mg
Capsules; Oral; Cloxacillin Sodium 500 mg
Cloxacillin Sodium 1 g/vial5.89 USD
Cloxacillin Sodium 2 g/vial7.69 USD
Cloxacillin Sodium 500 mg/vial4.79 USD
Granules for Suspension; Oral; Cloxacillin Sodium 125 mg / 5 ml
Injectable; Injection; Cloxacillin 250 mg
Injectable; Injection; Cloxacillin 500 mg
Injectable; Injection; Cloxacillin Sodium 1 g
Injectable; Injection; Cloxacillin Sodium 2 g
Injectable; Injection; Cloxacillin Sodium 250 mg
Injectable; Injection; Cloxacillin Sodium 500 mg
Novo-Cloxin 25 mg/ml Liquid0.05 USD
Novo-Cloxin 250 mg Capsule0.19 USD
Novo-Cloxin 500 mg Capsule0.38 USD
Nu-Cloxi 25 mg/ml Liquid0.05 USD
Nu-Cloxi 250 mg Capsule0.19 USD
Nu-Cloxi 500 mg Capsule0.38 USD
Powder for Solution; Oral; Cloxacillin Sodium 125 mg / 5 ml
Powder for Solution; Oral; Cloxacillin Sodium 250 mg / 5 ml
Solution; Oral; Cloxacillin Sodium 125 mg / 5 ml
Syrup; Oral; Cloxacillin Sodium 125 mg / 5 ml

Indications and Usages:

ATC codes:


ICD-10 codes:


Cloxacillin destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."CLOXACILLIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "cloxacillin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "cloxacillin". http://www.drugbank.ca/drugs/DB0114... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Cloxacillin?

Depending on the reaction of the Cloxacillin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Cloxacillin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Cloxacillin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Cloxacillin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Cloxacillin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Cloxacillin useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Cloxacillin drug as prescribed by the doctor?

Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Cloxacillin is mentioned below.
Visitors%
4 times in a day1
100.0%

Five visitors reported doses

What is the dose of Cloxacillin drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
201-500mg2
40.0%
101-200mg1
20.0%
1-5mg1
20.0%
11-50mg1
20.0%

One visitor reported time for results

What is the time duration Cloxacillin drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Cloxacillin drug. The time needed to show improvement in health condition after using the medicine Cloxacillin need not be same for all the users. It varies based on other factors.
Visitors%
1 day1
100.0%

One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Cloxacillin drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
Empty stomach1
100.0%

Three visitors reported age

Visitors%
16-292
66.7%
30-451
33.3%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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