Active ingredient: Cinnarizine

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Cinnarizine uses


Pharmacological action

Cinnarizine is a calcium channel blocker class IV with a predominant effect on the brain vessels, a derivative of piperazine. This medication improves cerebral, coronary and peripheral circulation. Cinnarizine violates the entrance of calcium ions into vascular smooth muscle cells. This drug lowers the tone of arteriolar smooth muscle, decreases the vasoconstrictor response to biogenic substances. Cinnarizine reduces the excitability of the vestibular apparatus. In patients with impaired peripheral circulation Cinnarizine improves blood flow and potentiates postischemic hyperemia. This medicine increases the resistance of tissue to hypoxia.

Pharmacokinetics

After oral administration Cinnarizine is absorbed from the gastrointestinal tract, Cmax in plasma is reached after 1-4 h. The plasma protein binding is 91%. This medication is metabolized. T1/2 is 3-6 hours. Cinnarizine is eliminated through the intestine largely unchanged, with the urine - mainly in the form of metabolites.

Why is Cinnarizine prescribed?

Ischemic attacks. Labyrinth disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea and vomiting of labyrinth origin). Motion sickness (as a prophylactic agent). Prophylaxis of migraine. Meniere's disease. Prevention and treatment of disorders of peripheral circulation - atherosclerosis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, acrocyanosis.

Dosage and administration

The dosage regimen is individual. Cinnarizine is taken orally in 25-50-75 mg 3 times / day after a meal. If necessary, the treatment can begin with half the dose and gradually increasing. To achieve the optimal therapeutic effect is used continuously for several months.

Cinnarizine side effects, adverse reactions

Digestive system: dyspepsia, dry mouth, rarely - cholestatic jaundice.

CNS: headache, drowsiness; in elderly patients in long-term use may be extrapyramidal symptoms, depression.

Allergic reactions: rarely - skin rash.

Other: weight gain, increased sweating, in rare cases - lupus-like syndrome, lichen planus.

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Cinnarizine contraindications

Hypersensitivity to Cinnarizine.

Using during pregnancy and breastfeeding

During pregnancy and lactation Cinnarizine usage is possible only in exceptional cases, when the expected benefit to the mother far outweighs the potential risk to the fetus or infant.

Special instructions

Use Cinnarizine with caution in patients with hypertension.

With prolonged use is recommended to perform control examination of liver, kidney, peripheral blood picture.

At the beginning of treatment you should refrain from potentially hazardous activities that require attention and speed of psychomotor reactions.

Cinnarizine drug interactions

When this drug applied simultaneously with:

- tricyclic antidepressants, hypnotics, drugs that have a sedative effect, alcohol, ethanol-containing medication increases the effects on the CNS.

- antihypertensive drugs increased hypotensive effect.

- nootropics, vasodilators - increases the action of nootropic drugs and vasodilators.

- phenylpropanolamine reduces sedation effect of Cinnarizine Quality Pharmaceutical Laboratory.

Cinnarizine in case of emergency / overdose

Treatment: gastric lavage, taking activated charcoal, symptomatic therapy. There is no a specific antidote.

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Cinnarizine available forms, composition, doses:


Indications and Usages:

ATC codes:


ICD-10 codes:


Cinnarizine destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


Frequently asked Questions

Can i drive or operate heavy machine after consuming Cinnarizine?

Depending on the reaction of the Cinnarizine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Cinnarizine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Cinnarizine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Cinnarizine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Cinnarizine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Cinnarizine drug as prescribed by the doctor?

Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Cinnarizine is mentioned below.
Visitors%
3 times in a day1
100.0%

Two visitors reported doses

What is the dose of Cinnarizine drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
11-50mg1
50.0%
51-100mg1
50.0%

One visitor reported time for results

What is the time duration Cinnarizine drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 week to notice the result from using Cinnarizine drug. The time needed to show improvement in health condition after using the medicine Cinnarizine need not be same for all the users. It varies based on other factors.
Visitors%
1 week1
100.0%

Visitor reported administration

No survey data has been collected yet

One visitor reported age

Visitors%
16-291
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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