Active ingredient: Cilastatin

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When are you taking this medicine?

Cilastatin uses


A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, Cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Indication: Combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, Cilastatin in and of itself does not have any antibacterial activity.

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Cilastatin available forms, composition, doses:


Indications and Usages:

ATC codes:


ICD-10 codes:


Cilastatin destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."CILASTATIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "Cilastatin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "Cilastatin". http://www.drugbank.ca/drugs/DB0159... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Cilastatin?

Depending on the reaction of the Cilastatin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Cilastatin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Cilastatin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Cilastatin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Cilastatin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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