Active ingredient: Cefuroxime

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Cefuroxime uses



Rx only

To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefuroxime for Injection, USP and other antibacterial drugs, cefuroxime for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.


cefuroxime for Injection, USP is a sterile semisynthetic, broad-spectrum, cephalosporin antibiotic for parenteral administration. It is the sodium salt of (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-methoxyimino-2-(fur-2-yl) acetamido] ceph-3-em-4-carboxylate, and it has the following chemical structure:

The empirical formula is C16H15N4NaO8S, representing a molecular weight of 446.4.

cefuroxime for Injection, USP contains approximately 54.2 mg (2.4 mEq) of sodium per gram of cefuroxime activity.

cefuroxime for Injection, USP in sterile crystalline form is supplied in Pharmacy Bulk Package equivalent to 7.5 g of cefuroxime as cefuroxime sodium. Solutions of cefuroxime for Injection, USP range in color from light yellow to amber, depending on the concentration and diluent used. The pH of freshly constituted solutions usually ranges from 6 to 8.5.

A pharmacy bulk package is a container of a sterile powder for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture service and are restricted to the preparation of admixtures for intravenous infusion. FURTHER DILUTION IS REQUIRED BEFORE USE.

cefuroxime Structural Formula



Following IV doses of 750 mg and 1.5 g, serum concentrations were approximately 50 and 100 mcg/mL, respectively, at 15 minutes. Therapeutic serum concentrations of approximately 2 mcg/mL or more were maintained for 5.3 hours and 8 hours or more, respectively. There was no evidence of accumulation of cefuroxime in the serum following IV administration of 1.5 g doses every 8 hours to normal volunteers. The serum half-life after IV injections is approximately 80 minutes.

Approximately 89% of a dose of cefuroxime is excreted by the kidneys over an 8-hour period, resulting in high urine concentrations.

Intravenous doses of 750 mg and 1.5 g produced urinary levels averaging 1,150 and 2,500 mcg/mL, respectively, during the first 8-hour period.

The concomitant oral administration of probenecid with cefuroxime slows tubular secretion, decreases renal clearance by approximately 40%, increases the peak serum level by approximately 30%, and increases the serum half-life by approximately 30%. cefuroxime is detectable in therapeutic concentrations in pleural fluid, joint fluid, bile, sputum, bone and aqueous humor.

cefuroxime is detectable in therapeutic concentrations in cerebrospinal fluid of adults and pediatric patients with meningitis. The following table shows the concentrations of cefuroxime achieved in cerebrospinal fluid during multiple dosing of patients with meningitis.

Patients Dose Number of Patients

Mean (Range) CSF cefuroxime


(mcg/mL) Achieved

Within 8 Hours

Post Dose

Pediatric patients

(4 weeks to 6.5 years)

200 mg/kg/day,

divided q 6 hours




Pediatric patients

(7 months to 9 years)

200 to 230 mg/kg/day, divided q 8 hours 6


(< 2-22.5)

Adults 1.5 grams q 8 hours 2



Adults 1.5 grams q 6 hours 10



cefuroxime is approximately 50% bound to serum protein.


cefuroxime has in vitro activity against a wide range of gram-positive and gram-negative organisms, and it is highly stable in the presence of beta-lactamases of certain gram-negative bacteria. The bactericidal action of cefuroxime results from inhibition of cell-wall synthesis.

cefuroxime is usually active against the following organisms in vitro.

Aerobes, Gram-positive: Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae; and Streptococcus pyogenes (and other streptococci). NOTE: Most strains of enterococci, e.g., Enterococcus faecalis (formerly Streptococcus faecalis), are resistant to cefuroxime. Methicillin-resistant staphylococci and Listeria monocytogenes are resistant to cefuroxime.

Aerobes, Gram-negative: Citrobacter spp., Enterobacter spp., Escherichia coli, Haemophilus influenzae (including ampicillin-resistant strains), Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumoniae), Moraxella (Branhamella) catarrhalis (including ampicillin- and cephalothin-resistant strains), Morganella morganii (formerly Proteus morganii), Neisseria gonorrhoeae (including penicillinase- and non-penicillinase-producing strains), Neisseria meningitidis, Proteus mirabilis, Providencia rettgeri (formerly Proteus rettgeri), Salmonella spp., and Shigella spp.

NOTE: Some strains of Morganella morganii, Enterobacter cloacae, and Citrobacter spp. have been shown by in vitro tests to be resistant to cefuroxime and other cephalosporins. Pseudomonas and Campylobacter spp., Legionella spp., Acinetobacter calcoaceticus, and most strains of Serratia spp. and Proteus vulgaris are resistant to most first- and second-generation cephalosporins.

Anaerobes: Gram-positive and gram-negative cocci (including Peptococcus and Peptostreptococcus spp.), gram-positive bacilli (including Clostridium spp.), and gram-negative bacilli (including Bacteroides and Fusobacterium spp.).

NOTE: Clostridium difficile and most strains of Bacteroides fragilis are resistant to cefuroxime.

Susceptibility Tests

Diffusion Techniques: Quantitative methods that require measurement of zone diameters give an estimate of antibiotic susceptibility. One such standard procedure1 that has been recommended for use with disks to test susceptibility of organisms to cefuroxime uses the 30 mcg cefuroxime disk. Interpretation involves the correlation of the diameters obtained in the disk test with the minimum inhibitory concentration for cefuroxime.

A report of “Susceptible” indicates that the pathogen is likely to be inhibited by generally achievable blood levels. A report of “Moderately Susceptible” suggests that the organism would be susceptible if high dosage is used or if the infection is confined to tissues and fluids in which high antibiotic levels are attained. A report of “Intermediate” suggests an equivocable or indeterminate result. A report of “Resistant” indicates that achievable concentrations of the antibiotic are unlikely to be inhibitory and other therapy should be selected.

Reports from the laboratory giving results of the standard single-disk susceptibility test for organisms other than Haemophilus spp. and Neisseria gonorrhoeae with a 30 mcg cefuroxime disk should be interpreted according to the following criteria:

Creatinine Clearance


Dose Frequency
>20 750 mg-1.5 grams q8h
10-20 750 mg q12h
<10 750 mg q24hSince cefuroxime for Injection, USP is dialyzable, patients on hemodialysis should be given a further dose at the end of the dialysis.

When only serum creatinine is available, the following formula2 (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function.

Males: clearance (mL/min) = Weight (kg) x (140 – age)
72 x serum creatinine (mg/dL)
Females: 0.85 x male value

NOTE: As with antibiotic therapy in general, administration of cefuroxime for Injection, USP should be continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or after evidence of bacterial eradication has been obtained; a minimum of 10 days of treatment is recommended in infections caused by Streptococcus pyogenes in order to guard against the risk of rheumatic fever or glomerulonephritis; frequent bacteriologic and clinical appraisal is necessary during therapy of chronic urinary tract infection and may be required for several months after therapy has been completed; persistent infections may require treatment for several weeks; and doses smaller than those indicated above should not be used. In staphylococcal and other infections involving a collection of pus, surgical drainage should be carried out where indicated.

Pediatric Patients Above 3 Months of Age: Administration of 50 to 100 mg/kg per day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime. The higher dosage of 100 mg/kg per day (not to exceed the maximum adult dosage) should be used for the more severe or serious infections.

In bone and joint infections, 150 mg/kg per day (not to exceed the maximum adult dosage) is recommended in equally divided doses every 8 hours. In clinical trials, a course of oral antibiotics was administered to pediatric patients following the completion of parenteral administration of cefuroxime for Injection, USP.

In cases of bacterial meningitis, a larger dosage of cefuroxime for Injection, USP is recommended, 200 to 240 mg/kg per day intravenously in divided doses every 6 to 8 hours.

In pediatric patients with renal insufficiency, the frequency of dosing should be modified consistent with the recommendations for adults.

Directions for Dispensing

Pharmacy Bulk Package – Not for Direct Infusion: The pharmacy bulk package is for use in a pharmacy admixture service only under a laminar flow hood. Entry into the vial must be made with a sterile transfer set or other sterile dispensing device, and the contents dispensed in aliquots using aseptic technique, the closure should be penetrated only one time using a suitable sterile dispensing set; which allows measured dispensing of the contents. The use of a syringe and needle is not recommended as it may cause leakage. AFTER INITIAL WITHDRAWAL USE ENTIRE CONTENTS OF VIAL PROMPTLY. ANY UNUSED PORTION MUST BE DISCARDED WITHIN 4 HOURS.

Preparation of Solution

Pharmacy Bulk Package – Not for Direct Infusion: This pharmacy bulk package is designed for use in the pharmacy in preparing admixtures for intravenous infusion only. Use of this product is restricted to a suitable work area, such as a laminar flow hood. The 7.5 grams pharmacy bulk package should be constituted with 77 mL of Sterile Water for Injection; each 8 mL of the resulting solution contains 750 mg of cefuroxime; 16 mL of solution contains 1.5 grams of cefuroxime.



After constitution, the intent of this pharmacy bulk package is for the preparation of solutions for IV infusion only.

Intravenous Administration: The IV route may be preferable for patients with bacterial septicemia or other severe or life-threatening infections or for patients who may be poor risks because of lowered resistance, particularly if shock is present or impending.

For intermittent IV infusion with a Y-type administration set , dosing can be accomplished through the tubing system by which the patient may be receiving other IV solutions. However, during infusion of the solution containing cefuroxime for Injection, USP, it is advisable to temporarily discontinue administration of any other solutions at the same site.

For continuous IV infusion , a solution of cefuroxime for Injection, USP may be added to an IV infusion pack containing one of the following fluids: 0.9% Sodium Chloride Injection; 5% Dextrose Injection; 10% Dextrose Injection; 5% Dextrose and 0.9% Sodium Chloride Injection; 5% Dextrose and 0.45% Sodium Chloride Injection; or 1/6 M Sodium Lactate Injection.

Solutions of cefuroxime for Injection, USP, like those of most beta-lactam antibiotics, should not be added to solutions of aminoglycoside antibiotics because of potential interaction.

However, if concurrent therapy with cefuroxime for Injection, USP and an aminoglycoside is indicated, each of these antibiotics can be administered separately to the same patient.

Compatibility and Stability

Intravenous: When the 7.5 g pharmacy bulk package is constituted as directed with Sterile Water for Injection the contents should be withdrawn without delay. However, should this not be possible, a maximum time of 4 hours from initial closure entry is permitted to complete fluid transfer operations. More dilute solutions, such as 750 mg or 1.5 g plus 100 mL of Sterile Water for Injection, 5% Dextrose Injection, or 0.9% Sodium Chloride Injection, also maintain satisfactory potency for 24 hours at room temperature and for 7 days under refrigeration.

These solutions may be further diluted to concentrations of between 1 and 30 mg/mL in the following solutions and will lose not more than 10% activity for 24 hours at room temperature or for at least 7 days under refrigeration: 0.9% Sodium Chloride Injection; 1/6 M Sodium Lactate Injection; Ringer’s Injection, USP; Lactated Ringer’s Injection, USP; 5% Dextrose and 0.9% Sodium Chloride Injection; 5% Dextrose Injection; 5% Dextrose and 0.45% Sodium Chloride Injection; 5% Dextrose and 0.225% Sodium Chloride Injection; 10% Dextrose Injection; and 10% Invert Sugar in Water for Injection.

Unused solutions should be discarded after the time periods mentioned above.

cefuroxime for Injection, USP has also been found compatible for 24 hours at room temperature when admixed in IV infusion with heparin (10 and 50 U/mL) in 0.9% Sodium Chloride Injection and Potassium Chloride (10 and 40 mEq/L) in 0.9% Sodium Chloride Injection. Sodium Bicarbonate Injection, USP is not recommended for the dilution of cefuroxime for Injection, USP.

Frozen Stability: Constitute the 7.5 g pharmacy bulk package vial as directed for IV administration. Immediately withdraw 8 mL or 16 mL from the 7.5 g pharmacy bulk package vial and add to a minibag containing 50 or 100 mL of 0.9% Sodium Chloride Injection or 5% Dextrose Injection and freeze. Frozen solutions are stable for 6 months when stored at -20°C. Frozen solutions should be thawed at room temperature and not refrozen. Do not force thaw by immersion in water baths or by microwave irradiation. Thawed solutions may be stored for up to 24 hours at room temperature or for 7 days in a refrigerator.

Note: Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit.

As with other cephalosporins, cefuroxime for Injection, USP powder as well as solutions and suspensions tend to darken, depending on storage conditions, without adversely affecting product potency.

The container may be hung by the attached bail band during dispensing of the contents.



Store cefuroxime for Injection, USP at 20° to 25°C (68° to 77°F). Protect From Light. cefuroxime for Injection, USP is a dry, white to off-white powder supplied in vials and infusion packs as follows:

cefuroxime for Injection, USP. cefuroxime sodium equivalent to 7.5 grams of cefuroxime per Pharmacy Bulk Package.

NDC 44567-712-10 7.5 gram vial Pharmacy Bulk Pack (Carton of 10)

Also available:

cefuroxime for Injection, USP. cefuroxime sodium equivalent to 750 mg or 1.5 grams cefuroxime per vial or infusion pack.

NDC 44567-710-10 750 mg vial (Carton of 10)

NDC 44567-711-10 1.5 gram vial (Carton of 10)

NDC 44567-720-10 750 mg infusion pack (Carton of 10)

NDC 44567-722-10 1.5 gram infusion pack (Carton of 10)


  • National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing. Third Informational Supplement. NCCLS Document M100-S3, Vol. 11, No. 17. Villanova, Pa: NCCLS; 1991.
  • Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16:31-41.

    CLINITEST® is a registered trademark of Ames Division, Miles Laboratories, Inc.

Manufactured for:

WG Critical Care, LLC

Paramus, New Jersey 07652

Revised: October 2012



Cefuroxime available forms, composition, doses:

Apo-Cefuroxime 250 mg Tablet1.02 USD
Apo-Cefuroxime 500 mg Tablet2.02 USD
Cedax 400 mg capsule16.13 USD
Ceftin 20 500 mg tablet Bottle436.36 USD
Ceftin 250 mg tablet1.82 USD
Ceftin 500 mg tablet3.61 USD
Cefuroxime 1.5 g/50 ml bag16.8 USD
Cefuroxime Axetil 250 mg/5ml Suspension 100ml Bottle121.27 USD
Cefuroxime axetil 250 mg tablet2.82 USD
Cefuroxime axetil 500 mg tablet8.11 USD
Cefuroxime sod 1.5 gm vial13.44 USD
Cefzil 125 mg/5ml Suspension 100ml Bottle48.36 USD
Cefzil 250 mg tablet4.76 USD
Cefzil 250 mg/5ml Suspension 100ml Bottle87.62 USD
Cefzil 500 mg tablet9.77 USD
Duricef 1 gm tablet7.35 USD
Duricef 250 mg/5ml Suspension 50ml Bottle22.99 USD
Duricef 500 mg/5ml Suspension 100ml Bottle59.36 USD
Duricef 500 mg/5ml Suspension 75ml Bottle46.93 USD
Injectable; Injection; Cefuroxime Sodium 1.5 g
Injectable; Injection; Cefuroxime Sodium 1500 mg
Injectable; Injection; Cefuroxime Sodium 250 mg
Injectable; Injection; Cefuroxime Sodium 7.5 g
Injectable; Injection; Cefuroxime Sodium 75 mg / ml
Injectable; Injection; Cefuroxime Sodium 750 mg
Maxipime 1 gm piggyback vial23.24 USD
Maxipime 1 gram vial21.7 USD
Maxipime 2 gram vial43.04 USD
Powder for Suspension; Oral; Cefuroxime Axetil 125 mg / 5 ml
Powder for Suspension; Oral; Cefuroxime Axetil 250 mg / 5 ml
Ratio-Cefuroxime 250 mg Tablet1.02 USD
Ratio-Cefuroxime 500 mg Tablet2.02 USD
Rocephin 1 gm Solution Vial65.53 USD
Rocephin 1 gm vial62.02 USD
Rocephin 10 gm vial478.32 USD
Rocephin 2 gm vial97.5 USD
Tablets, Film-Coated; Oral; Cefuroxime Axetil 125 mg
Tablets, Film-Coated; Oral; Cefuroxime Axetil 250 mg
Tablets, Film-Coated; Oral; Cefuroxime Axetil 500 mg
Tablets; Oral; Cefuroxime Axetil 125 mg
Tablets; Oral; Cefuroxime Axetil 250 mg
Tablets; Oral; Cefuroxime Axetil 500 mg
Velosef 250 mg capsule1.03 USD
Velosef 250 mg/5ml Suspension 100ml Bottle23.99 USD
Velosef 500 mg capsule2.02 USD
Zinacef 1.5 gm add-vant vial13.94 USD
Zinacef 1.5 gm vial13.45 USD
Zinacef 7.5 gm vial65.94 USD
Zinacef-water 1.5 gm/50 ml0.32 USD


Indications and Usages:

ATC codes:

ICD-10 codes:

Cefuroxime destination | category:


Drugs with same active ingredients (Pharmaceutical companies):


  1. Dailymed."CEFUROXIME INJECTION, POWDER, FOR SOLUTION [WG CRITICAL CARE, LLC]". (accessed August 28, 2018).
  2. "cefuroxime". (accessed August 28, 2018).
  3. "cefuroxime". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Cefuroxime?

Depending on the reaction of the Cefuroxime after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Cefuroxime not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Cefuroxime addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Cefuroxime, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Cefuroxime consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Seven visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Cefuroxime drug as prescribed by the doctor?

Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of website users about the frequency of taking the drug Cefuroxime is mentioned below.
Twice in a day4
3 times in a day2
4 times in a day1

Five visitors reported doses

What is the dose of Cefuroxime drug you are taking?
According to the survey conducted among website users, the maximum number of people are using the following dose 501mg-1g. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

Two visitors reported time for results

What is the time duration Cefuroxime drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say website users needed 2 weeks to notice the result from using Cefuroxime drug. The time needed to show improvement in health condition after using the medicine Cefuroxime need not be same for all the users. It varies based on other factors.
2 weeks1
5 days1

One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Cefuroxime drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
After food1

One visitor reported age


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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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