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DRUGS & SUPPLEMENTS
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Active ingredient: Ampicillin Sodium
What are the side effects you encounter while taking this medicine? |
Ampicillin Sodium uses
Pharmacological action
Ampicillin Sodium is an antibiotic of semisynthetic broad-spectrum penicillin group. This medication has a bactericidal effect by suppressing the synthesis of bacterial cell walls. Ampicillin Sodium is active against aerobic gram-positive bacteria: Staphylococcus spp., Streptococcus spp., Enterococcus spp., Listeria monocytogenes; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Ampicillin Sodium destroyed by penicillinase. This drug is acid-resistant.
Pharmacokinetics
After oral administration Ampicillin Sodium is well absorbed from the gastrointestinal tract. This medicine is distributed in most organs and tissues; crosses the placental barrier, poorly penetrates the BBB. When inflammation of the meninges, BBB permeability increases dramatically. 30% of Ampicillin Sodium is metabolized in the liver. This medication is excreted in the urine and bile.
Why is Ampicillin Sodium prescribed?
Infectious-inflammatory diseases caused by organisms susceptible to Ampicillin Sodium: including ear infections, throat, nose, odontogenic infections, bronchopulmonary infections, acute and chronic urinary tract infections, gastrointestinal infections, gynecological infections, meningitis, endocarditis, septicemia, sepsis, rheumatic fever, erysipelas, scarlet fever, infections of skin and soft tissues.
Dosage and administration
The dosing regimen of Ampicillin Sodium is set individually depending on the severity, localization of infection and sensitivity of the pathogen.
For adults for oral administration a single dose of this medication is 250-500 mg, the multiplicity of the reception is 4 times / day. The dose for children weighing up to 20 kg is 12.5-25 mg / kg every 6 hours.
For IV and IM using the single dose for adults is 250-500 mg every 4-6 hours; for children the single dose is 25-50 mg / kg.
The duration of treatment depends on the localization of infection and features of the disease.
The maximum oral daily dose for adults is 4 g, for IM and IV administration - 14 g.
Ampicillin Sodium side effects, adverse reactions
Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, extremely rare - anaphylactic shock.
Digestive system: nausea, vomiting.
The effects caused by chemotherapeutic action: oral candidiasis, vaginal candidiasis, intestinal dysbiosis, colitis caused by Clostridium difficile.
Ampicillin Sodium contraindications
Infectious mononucleosis, lymphatic leukemia, increased sensitivity to Ampicillin Sodium and other penicillins, abnormal liver function.
Using during pregnancy and breastfeeding
Perhaps the use of Ampicillin Sodium during pregnancy if it may be needed. Ampicillin Sodium is excreted in breast milk in low concentrations. If necessary to use Ampicillin Sodium in the lactation period it should be solved the issue of termination of breastfeeding.
Category effects on the fetus by FDA - B.
Special instructions
In the course of treatment with Ampicillin Sodium there is need the regular control of renal function, liver and peripheral blood picture. Patients with impaired renal function requires correction dosing regimen in accordance with the values of CCr.
When used in high doses in patients with renal insufficiency it may be toxic effects on the CNS.
For using of Ampicillin Sodium in patients with bacteremia it can be bacteriolysis reaction (Jarisch-Herxheimer reaction).
Ampicillin Sodium drug interactions
Simultaneous administration of Ampicillin Sodium with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) there is manifested synergism; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.
Ampicillin Sodium enhances the effect of indirect anticoagulants by inhibiting the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Ampicillin Sodium decreases the effect of drugs in the process of metabolism which produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Ampicillin Sodium which may be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of Ampicillin Sodium Upha Corporation. Ascorbic acid increases the absorption of Ampicillin Sodium.
Ampicillin Sodium decreases the effectiveness of oral contraceptives.
Ampicillin Sodium in case of emergency / overdose
Symptoms: the toxic effect on the central nervous system (especially in patients with renal insufficiency), nausea, vomiting, diarrhea, impaired water and electrolyte balance (as a consequence of vomiting and diarrhea).
Treatment: gastric lavage, activated charcoal, saline laxatives, a maintain of water and electrolyte balance, symptomatic therapy. This drug is derived by means of hemodialysis.
Ampicillin Sodium available forms, composition, doses:
Indications and Usages:
ATC codes:
ICD-10 codes:
Ampicillin Sodium destination | category:
Drugs with same active ingredients (Pharmaceutical companies):
References
- Dailymed."AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [SANDOZ INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."AMPICILLIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "ampicillin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Ampicillin Sodium?Depending on the reaction of the Ampicillin Sodium after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ampicillin Sodium not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Ampicillin Sodium addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Ampicillin Sodium, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ampicillin Sodium consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
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No survey data has been collected yetOne visitor reported doses
What is the dose of Ampicillin Sodium drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 201-500mg | 1 | 100.0% | |
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The information was verified by Dr. Rachana Salvi, MD Pharmacology