Active ingredient: Ampicillin Trihydrate

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Ampicillin Trihydrate uses


Pharmacological action

Ampicillin Trihydrate is an antibiotic of semisynthetic broad-spectrum penicillin group. This medication has a bactericidal effect by suppressing the synthesis of bacterial cell walls. Ampicillin Trihydrate is active against aerobic gram-positive bacteria: Staphylococcus spp., Streptococcus spp., Enterococcus spp., Listeria monocytogenes; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Ampicillin Trihydrate destroyed by penicillinase. This drug is acid-resistant.

Pharmacokinetics

After oral administration Ampicillin Trihydrate is well absorbed from the gastrointestinal tract. This medicine is distributed in most organs and tissues; crosses the placental barrier, poorly penetrates the BBB. When inflammation of the meninges, BBB permeability increases dramatically. 30% of Ampicillin Trihydrate is metabolized in the liver. This medication is excreted in the urine and bile.

Why is Ampicillin Trihydrate prescribed?

Infectious-inflammatory diseases caused by organisms susceptible to Ampicillin Trihydrate: including ear infections, throat, nose, odontogenic infections, bronchopulmonary infections, acute and chronic urinary tract infections, gastrointestinal infections, gynecological infections, meningitis, endocarditis, septicemia, sepsis, rheumatic fever, erysipelas, scarlet fever, infections of skin and soft tissues.

Dosage and administration

The dosing regimen of Ampicillin Trihydrate is set individually depending on the severity, localization of infection and sensitivity of the pathogen.

For adults for oral administration a single dose of this medication is 250-500 mg, the multiplicity of the reception is 4 times / day. The dose for children weighing up to 20 kg is 12.5-25 mg / kg every 6 hours.

For IV and IM using the single dose for adults is 250-500 mg every 4-6 hours; for children the single dose is 25-50 mg / kg.

The duration of treatment depends on the localization of infection and features of the disease.

The maximum oral daily dose for adults is 4 g, for IM and IV administration - 14 g.

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Ampicillin Trihydrate side effects, adverse reactions

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, extremely rare - anaphylactic shock.

Digestive system: nausea, vomiting.

The effects caused by chemotherapeutic action: oral candidiasis, vaginal candidiasis, intestinal dysbiosis, colitis caused by Clostridium difficile.

Ampicillin Trihydrate contraindications

Infectious mononucleosis, lymphatic leukemia, increased sensitivity to Ampicillin Trihydrate and other penicillins, abnormal liver function.

Using during pregnancy and breastfeeding

Perhaps the use of Ampicillin Trihydrate during pregnancy if it may be needed. Ampicillin Trihydrate is excreted in breast milk in low concentrations. If necessary to use Ampicillin Trihydrate in the lactation period it should be solved the issue of termination of breastfeeding.

Category effects on the fetus by FDA - B.

Special instructions

In the course of treatment with Ampicillin Trihydrate there is need the regular control of renal function, liver and peripheral blood picture. Patients with impaired renal function requires correction dosing regimen in accordance with the values of CCr.

When used in high doses in patients with renal insufficiency it may be toxic effects on the CNS.

For using of Ampicillin Trihydrate in patients with bacteremia it can be bacteriolysis reaction (Jarisch-Herxheimer reaction).

Ampicillin Trihydrate drug interactions

Simultaneous administration of Ampicillin Trihydrate with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) there is manifested synergism; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Ampicillin Trihydrate enhances the effect of indirect anticoagulants by inhibiting the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.

Ampicillin Trihydrate decreases the effect of drugs in the process of metabolism which produce PABA.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Ampicillin Trihydrate which may be accompanied by an increase in its concentration in blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of Ampicillin Trihydrate Upha Corporation. Ascorbic acid increases the absorption of Ampicillin Trihydrate.

Ampicillin Trihydrate decreases the effectiveness of oral contraceptives.

Ampicillin Trihydrate in case of emergency / overdose

Symptoms: the toxic effect on the central nervous system (especially in patients with renal insufficiency), nausea, vomiting, diarrhea, impaired water and electrolyte balance (as a consequence of vomiting and diarrhea).

Treatment: gastric lavage, activated charcoal, saline laxatives, a maintain of water and electrolyte balance, symptomatic therapy. This drug is derived by means of hemodialysis.

Ampicillin Trihydrate available forms, composition, doses:


Indications and Usages:

ATC codes:


ICD-10 codes:


Ampicillin Trihydrate destination | category:


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Drugs with same active ingredients (Pharmaceutical companies):


References

  1. Dailymed."AMPICILLIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "ampicillin". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "ampicillin". http://www.drugbank.ca/drugs/DB0041... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Ampicillin Trihydrate?

Depending on the reaction of the Ampicillin Trihydrate after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ampicillin Trihydrate not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Ampicillin Trihydrate addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Ampicillin Trihydrate, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ampicillin Trihydrate consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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