Active ingredient: Amantadine Hydrochloride

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Amantadine Hydrochloride uses

Pharmacological action

Amantadine Hydrochloride is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.

This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. Amantadine Hydrochloride inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater Amantadine Hydrochloride influences on stiffness.

This medicine inhibits the penetration of influenza A virus into the cell.


Amantadine Hydrochloride after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of Amantadine Hydrochloride sulfate is 12-13 hours, in contrast to Amantadine Hydrochloride hydrochloride, which T1/2 is 30 hours.

Why is Amantadine Hydrochloride prescribed?

Parkinson's disease, Parkinson's syndrome.

Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.

Prevention (including in combination with vaccination) and treatment of influenza A.

Dosage and administration

For oral administration the single dose is 100-200 mg.

IV in the form of infusion in 200 mg during 3 hours.

The frequency and duration of Amantadine Hydrochloride use depends on the evidence, the patient's response to treatment, the epidemiological situation.

The maximum dose for oral administration is 600 mg / day.

Amantadine Hydrochloride side effects, adverse reactions

CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.

Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.

Digestive system: rarely - anorexia, nausea, constipation, dry mouth.

Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.

Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities.


Amantadine Hydrochloride contraindications

Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to Amantadine Hydrochloride.

Using during pregnancy and breastfeeding

The use of Amantadine Hydrochloride in pregnancy is possible only under strict indications and under the supervision of a physician.

If necessary to use during lactation it been should decide on the termination of breastfeeding.

Category of the fetus by FDA - C.

Special instructions

Use Amantadine Hydrochloride with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of Amantadine Hydrochloride is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.

An information about the effectiveness of Amantadine Hydrochloride to reduce extrapyramidal disorders during treatment with antipsychotic drugs are contradictory.

During treatment avoid drinking alcohol.

In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.

Amantadine Hydrochloride drug interactions

When this drug applied simultaneously with:

- may increase the side effects of other antiparkinsonian medications.

- thiazide diuretics can not been excluded the possibility of toxic effects of Amantadine Hydrochloride (ataxia, agitation, hallucinations), probably by reducing its renal clearance.

- quinine, quinidine may decrease the excretion of Amantadine Hydrochloride in urine.

There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.

Amantadine Hydrochloride available forms, composition, doses:

Indications and Usages:

ATC codes:

ICD-10 codes:

Amantadine Hydrochloride destination | category:


Drugs with same active ingredients (Pharmaceutical companies):


  1. Dailymed."AMANTADINE HYDROCHLORIDE TABLET [ACTAVIS PHARMA, INC.]". (accessed August 28, 2018).
  2. "amantadine". (accessed August 28, 2018).
  3. "amantadine". (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Amantadine Hydrochloride?

Depending on the reaction of the Amantadine Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Amantadine Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Amantadine Hydrochloride addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Amantadine Hydrochloride, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Amantadine Hydrochloride consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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