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DRUGS & SUPPLEMENTS
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Zylol
What are the side effects you encounter while taking this medicine? |
Zylol uses
Pharmacological action
Zylol is a medication that violates the synthesis of uric acid. This drug is a structural analog of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing uric acid deposits and prevents their formation in tissues and kidney. Zylol increases urinary excretion of hypoxanthine and xanthine.
Pharmacokinetics
After oral administration Zylol is almost entirely absorbed from the gastrointestinal tract. This medication is metabolized to form alloxantin, which retains the ability to sufficiently long to inhibit xanthine oxidase. Cmax of Zylol in the blood plasma is reached after an average of 1.5 h, alloxantin - in 4.5 h after a single dose.
T1/2 of Zylol is 1-2 hours, alloxantin - about 15 hours. About 20% of the administered dose is excreted through the intestines and the rest by kidneys.
Why is Zylol prescribed?
Treatment and prevention of gout and hyperuricemia different genesis (including in conjunction with nephrolithiasis, renal failure, uric acid nephropathy). Recurrent mixed calcium oxalate kidney stones if hyperuricosuria. Increased production of urate due to enzyme disorders. Prevention of acute kidney disease in cytostatic and radiotherapy of tumors and leukemia, as well as full medical starvation.
Dosage and administration
The dosing regimen of Zylol is set individually under the control of concentrations of urate and uric acid in blood and urine. The ora ldose for adults is 100-900 mg / day depending on the severity of the disease. The frequency of admission is 2-4 times / day after a meal. For children under the age of 15 years - 10-20 mg / kg / day or 100-400 mg / day.
Maximum doses: if renal dysfunction - 100 mg / day. Increasing the dose is possible when on the background of the therapy remains an increased concentration of urate in the blood and urine.
Zylol side effects, adverse reactions
Cardio-vascular system: in single cases - hypertension, bradycardia.
Digestive system: possible dyspepsia (including nausea, vomiting), diarrhea, transient increase of transaminases in blood serum; rarely - hepatitis, in single cases - stomatitis, liver function (transient increase of transaminases and alkaline phosphatase), steatorrhea.
CNS and peripheral nervous system: in single cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, seizures, neuropathy, visual impairment, cataracts, changes in the papilla of the optic nerve, disorders of taste sensations.
Hemopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function).
Urinary system: rarely - interstitial nephritis, in single cases - edema, uremia, hematuria.
Endocrine system: in single cases - sterility, impotence, gynecomastia, diabetes.
Metabolism: in single cases - hyperlipidemia.
Allergic reactions: skin rash, redness, itching; in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome.
Dermatological reactions: in rare cases - furunculosis, alopecia, discoloration of hair.
Zylol contraindications
Pronounced liver function and / or renal disease, pregnancy, lactation, hypersensitivity to Zylol.
Using during pregnancy and breastfeeding
Zylol is contraindicated during pregnancy and lactation.
Category effects on the fetus by FDA - C.
Special instructions
It is necessary to maintain urine output of at least 2 liters a day and a neutral or slightly alkaline reaction of urine, because it prevents the precipitation of urate and the formation of concretions. You should not begin therapy with Zylol until complete relief of acute attack of gout; during the first month of treatment is recommended prophylactic administration of NSAIDs or colchicine; in the case of an acute attack of gout during therapy was added to the anti-inflammatory drugs. If impaired renal and liver function (increased risk of side effects), the dose is decreased. First 6-8 weeks of treatment need regular liver function tests, and blood diseases require regular laboratory monitoring.
When a skin rash this drug is overturned, after the disappearance of the not copious rash there are possible a reappointment of the drug in its treatment of relapsed immediately terminate.
Use of azathioprine or 6-mercaptopurine on the background of Zylol permits a 4-fold reduction in their doses. This medication combined with a care with vidarabine.
Zylol drug interactions
With the simultaneous administration Zylol increases the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic agents.
Uricosuric medicines and salicylates in high doses reduce the activity of Zylol Biogaran.
With the simultaneous administration of Zylol and cytostatics there is often manifested myelotoxic effect than when applied separatively.
With the simultaneous administration of this drug and azathioprine or mercaptopurine it is observed accumulation of the latter in the body, because in connection with the activity of xanthine oxidase inhibition with Zylol necessary to biotransformation of drugs, slowing their metabolism and elimination.
Zylol in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.
Treatment: forced diuresis, hemodialysis and peritoneal dialysis.
Zylol pharmaceutical active ingredients containing related brand and generic drugs:
Zylol available forms, composition, doses:
Zylol destination | category:
Zylol Anatomical Therapeutic Chemical codes:
Zylol pharmaceutical companies:
References
- Dailymed."ALLOPURINOL TABLET [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."ALLOPURINOL; LESINURAD: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "allopurinol". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Zylol?Depending on the reaction of the Zylol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zylol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Zylol addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Zylol, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zylol consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetOne visitor reported side effects
Did you get side effects while taking the Zylol drug, or were there no side effects?According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Zylol medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
| Visitors | % | ||
|---|---|---|---|
| It has side effects | 1 | 100.0% | |
Visitor reported price estimates
No survey data has been collected yetVisitor reported frequency of use
No survey data has been collected yetVisitor reported doses
No survey data has been collected yetVisitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetOne visitor reported age
| Visitors | % | ||
|---|---|---|---|
| > 60 | 1 | 100.0% | |
Visitor reviews
There are no reviews yet. Be the first to write one! |
The information was verified by Dr. Rachana Salvi, MD Pharmacology