DRUGS & SUPPLEMENTS
Zoter is an antiviral agent. Thymidine kinase of virus-infected cells actively converts Zoter through a series of sequential reactions in the mono-, di- and triphosphate of Zoter. The latter interacts with the viral DNA polymerase, and embedded in DNA, which is synthesized for new viruses. Thus it is formed a "defective" viral DNA which leads to suppression of replication of new generations of viruses.
This mediciine Zoter is active against Herpes Simplex virus types 1 and 2, Varicella Zoster virus, Epstein-Barr virus and cytomegalovirus.
For oral administration bioavailability is 15-30%. Widely distributed in tissues and body fluids. Plasma protein binding is 9-33%. Metabolised in liver. T1/2 for oral administration - 3.3 h, intravenous - 2.5 hours; Zoter excreted in the urine, also in small quantities - with feces.
Why is Zoter prescribed?
For systemic use : infections caused by Herpes Simplex virus types 1 and 2 and Varicella Zoster; prevention of infections caused by viruses Herpes Simplex and Varicella Zoster (including in patients with low immunity); in combined therapy with the pronounced immunodeficiency (including in the clinical picture of HIV infection) and in patients undergoing marrow transplantation, prevention of cytomegalovirus infection after marrow transplantation.
For topical use in ophthalmology: keratitis and other eye damage caused by Herpes Simplex virus.
For external use: infections of the skin caused by Herpes Simplex virus and Varicella Zoster like Herpes Simplex of the skin and mucous membranes, genital herpes (primary and recurrent) localized zoster (support therapy).
Dosage and administration
Zoter for oral usage for adults and children older than 2 years - 200-400 mg of 3-5 times / day, if necessary - to 20 mg / kg (up to 800 mg per dose) 4 times / day. For children under 2 years are used in doses equal to half the adult dose. Duration of treatment - 5-10 days. In renal insufficiency is recommended correction dosing regimen.
IV in adults and children over 12 years - 5-10 mg / kg, the interval between infusions - 8 hours. Children under the age of 3 months to 12 years - 250-500 mg / m2 body surface, the interval between infusions - 8 hours, for infants dose is 10 mg / kg, the interval between infusions - 8 hours.
In renal insufficiency must be corrected dosing regimen.
Locally and externally applied 5 times / 24 h. Dose and duration of treatment depends on the testimony and the use of dosage form.
Maximum dose for adults for IV usage is 30 mg / kg / 24 h.
Zoter side effects, adverse reactions
For oral usage: nausea, vomiting, diarrhea, abdominal pain, skin rash, headache, dizziness, fatigue, reduced concentration, hallucinations, drowsiness or insomnia, fever, rarely - hair loss, a transient increase in blood concentrations of bilirubin, urea, creatinine, liver enzymes, lymphocytopenia, eritropeniya, leukopenia.
For IV usage: acute renal failure, crystalluria, encephalopathy, phlebitis, or inflammation at the injection site, nausea, vomiting.
For topically usage: a burning sensation in the application area, superficial punctate keratitis, blepharitis, conjunctivitis.
For external usage: in the application area may be a burning sensation, skin rash, itching, peeling, erythema, dry skin in contact with mucous membranes - inflammation.
Hypersensitivity to Zoter and valaciclovir; for IV usage - lactation (breast feeding).
Using during pregnancy and breastfeeding
Pregnancy. Perhaps, if the expected effect of the therapy outweighs the potential risk to the fetus ; Zoter passes through the placenta. Data on the outcome of pregnancy in women taking Zoter systemic action in the I trimester of pregnancy showed no increase in birth defects compared with the total population. Since the observation was included a small number of women, reliable and definitive conclusions about the safety of Zoter in pregnancy can be done.
Breastfeeding. Zoter penetrates into breast milk. After taking Zoter by mouth, it was determined in breast milk in concentrations, the ratio of which, with concentrations in blood plasma was 0,6-1,4. At these concentrations in breast milk, children who are breastfed can receive Zoter at a dose of 0.3 mg / kg / day. Given this, should appoint Zoter lactating women with caution, only if necessary.
Do not use Zoter with severely impaired renal function.
Note that the application of Zoter may develop acute renal failure due to precipitate formation of crystals of Zoter, which is especially likely during rapid IV introduction, the simultaneous use of nephrotoxic drugs in patients with impaired renal function and lack of water stress.
When applying aciclovir should monitor renal function (determination of the level in the blood urea nitrogen and creatinine in blood plasma).
Treatment of elderly patients should be conducted with a sufficient increase in water load and under the supervision of a physician, because among these patients increased half-life of Zoter.
In the treatment of genital herpes should avoid sex or use condoms, because use of Zoter does not prevent transmission to partners.
This medication Zoter in the form of dosage forms for topical use should not be applied to mucous membranes of the mouth, eyes, vagina.
Zoter drug interactions
With simultaneous use of probenecid decreases the tubular secretion of Zoter, and thereby increases the concentration in blood plasma and the half-life of Zoter.
With simultaneous use of Zoter with other nephrotoxic drugs increases the risk of nephrotoxicity.
Enhancing effect of Zoter is noted while appointing immunostimulators.
When mixed solutions should be considered an alkaline reaction to Zoter for IV introduction (pH 11).
Zoter in case of emergency / overdose
Symptoms: headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, renal failure, lethargy, convulsions, coma.
Treatment: symptomatic therapy, the maintenance of vital functions, adequate hydration, hemodialysis (especially in acute renal failure and anuria).There is no data for overdose when applied topically.
Zoter pharmaceutical active ingredients containing related brand and generic drugs:
Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.
Zoter available forms, composition, doses:
Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.
Zoter destination | category:
Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.
Zoter Anatomical Therapeutic Chemical codes:
A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.
Zoter pharmaceutical companies:
Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.
Frequently asked QuestionsCan i drive or operate heavy machine after consuming Zoter?
Depending on the reaction of the Zoter after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zoter not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Zoter addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Reviewsdrugs.com conducted a study on Zoter, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zoter consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
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The information was verified by Dr. Arunabha Ray, MD Pharmacology