Zopinox

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Zopinox uses


Pharmacological action

Zopinox is a sleeping drug from group of cyclopyrrolone derivatives. This drug is "non benzodiazepine" agonist of benzodiazepine receptors. Zopinox also has sedative, anxiolytic, muscle-relaxing center, anticonvulsant and amnesic properties. Like a derivative of benzodiazepine Zopinox enhances GABA-ergic processes in the brain, interacting with the benzodiazepine receptors, as a result of the increased sensitivity of GABA-receptors to the neurotransmitter. However, Zopinox apparently interacts with other parts of the benzodiazepine receptor than benzodiazepines.

Zopinox reduced sleep time, reduces the number of nighttime awakenings, increases total sleep time. This medication almost has no effect on sleep structure, does not reduce significantly the amount of REM sleep. Consequences of the phenomenon of waking up are missing or expressed little. Readmission Zopinox are not accompanied by cumulation.

Pharmacokinetics

Zopinox rapidly and completely absorbed from the gastrointestinal tract. Cmax achieved within 1-3 hours. Zopinox easily passes through gistogematicheskie barriers including the BBB and it is distributed in organs and tissues including brain. T1/2 is 5.5-6 hours, not accumulates.

Why is Zopinox prescribed?

Sleep disturbance, transient, situational or chronic insomnia; sleep disturbances in mental disorders, bronchial asthma with nocturnal seizures (in combination with single dose daily dose of theophylline).

Dosage and administration

The average therapeutic dose of Zopinox is 7.5 mg orally at night, in cases of severe insomnia the dose can be increased up to 15 mg. In elderly patients, as well as abnormal liver function is used 3.75 mg.

Zopinox side effects, adverse reactions

Digestive system: a feeling of bitter or metallic taste in the mouth, dry mouth, nausea, and vomiting.

CNS: dizziness, headache, drowsiness, confusion, anterograde amnesia, hallucinations, nightmares.

Dermatologic reactions: skin rash.

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Zopinox contraindications

Severe respiratory failure, pregnancy, lactation, children and teens under 15 years old, hypersensitivity to Zopinox.

Using during pregnancy and breastfeeding

Zopinox is contraindicated during pregnancy (especially in I and III trimester) and lactation (breastfeeding). If a woman uses Zopinox in III trimester of pregnancy there are possible violations of the nervous system in the newborn, the emergence of withdrawal syndrome. If the woman is prescribed by a doctor took Zopinox immediately prior to labor and delivery, it needs a constant medical surveillance for the newborn. At the time of treatment it should be stoped breastfeeding (zopiclone penetrates into breast milk).

Special instructions

With caution use in patients with severe liver failure.

Risk of drug dependence is minimal if the duration of Zopinox did not exceed 4 weeks. However, the potential danger of Zopinox dependence to exist.

During the period of treatment patients should to exclude the use of alcohol.

On the next day after taking the drug it should be cautious to drive and operate machinery.

Zopinox drug interactions

Simultaneous administration of Zopinox with trimipramine reduces the concentration of trimipramine in plasma and its effect.

Zopinox increases the influence of CNS depressants.

Zopinox in case of emergency / overdose

Symptoms: CNS depression of varying severity (from drowsiness to loss of consciousness).

Treatment: gastric lavage, taking activated charcoal, if necessary - symptomatic therapy. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital). Hemodialysis is ineffective.

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Zopinox pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Zopinox available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Zopinox destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Zopinox Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Zopinox pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. "zopiclone". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  2. "zopiclone". http://www.drugbank.ca/drugs/DB0119... (accessed August 28, 2018).
  3. "zopiclone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Zopinox?

Depending on the reaction of the Zopinox after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zopinox not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Zopinox addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Zopinox, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zopinox consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

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Visitor reported price estimates

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Visitor reported frequency of use

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One visitor reported doses

What is the dose of Zopinox drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
6-10mg1
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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