Zimnic-O

What are the side effects you encounter while taking this medicine?
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Zimnic-O uses

Zimnic-O consists of Cefixime, Ofloxacin.

Cefixime:


Zimnic-O information

Zimnic-O (Cefixime) is a semi-synthetic cephalosporin antibiotic, destined for oral use, which is able to reduce the development of the drug resistant bacteria.

Zimnic-O indications

Zimnic-O (Cefixime) is usually prescribed by doctors and personal health care providers to patients who are suffering from bacterial infections of the ears, throat, chest, urinary tract and to the individuals who have been diagnosed with the presence of a mild form of gonorrhea.

Zimnic-O (Cefixime) may also be recommended in the treatment of other medical conditions, but only if the personal health care provider, pharmacist or doctor recommends it.

Zimnic-O warnings

Patients should inform their doctor if they have had allergies to penicillin and cephalosporin antibiotics, if they have stomach and intestinal diseases (such as colitis). If the patients see no amelioration of the symptoms after a few days of treatment they should announce their caregiver. Patients who are experiencing vomiting, nausea and severe diarrhea during the treatment with Zimnic-O (Cefixime) should talk with their doctor before taking anti-diarrheal drugs, because some of these medical products (like Lomotil or Paregoric) may worsen these symptoms.

The intake of Zimnic-O (Cefixime) is known to cause false urine-sugar test results in the case of the diabetic patients. These patients should tell their doctor that they are taking Zimnic-O (Cefixime), before they submit an urine sample. Individuals who are suffering from any kidney disorder should discuss with their doctor before beginning the treatment with this medicine, because they usually need dose adjustments in order for this drug not to interfere with their medical condition.

Women who are pregnant or are planning to become pregnant should discuss this matter with their personal health care provider or doctor, before beginning the treatment with Zimnic-O (Cefixime), as this medicine may harm the baby.

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Zimnic-O intake guidelines

Patients are recommended to ask their doctor how to take every dose of Zimnic-O (Cefixime) in order to obtain the best results during and after the treatment. Patients should pay attention to the doctor's recommendations and under no circumstances should they deviate from them. In the cases in which the patients have more questions about their treatment they should ask their doctor or pharmacist for further information.

As we said before, the dose of this drug must be adjusted for patients who are suffering from renal impairment, for individuals who are undergoing ambulatory peritoneal dialysis and hemodialysis.

This medicine can be taken in without food, but the patients who develop an upset stomach are recommended to take it with food, even if food slows down the rate of Zim's absorption. Patients, who are using a liquid from of this medicine, are recommended to use a measuring spoon, in order to be able to accurately measure their dose of Zimnic-O (Cefixime).

Zimnic-O dosage

The individuals will be prescribed by their personal health care provider the exact dose of Zimnic-O (Cefixime) that they should use daily. Patients should not ignore the doctor's recommendations. Adult patients who are suffering from urethral gonococcal infections and uncomplicated cervical infections are usually recommended 400 mg per day. Children are recommended to take 8 mg per kilogram daily. This quantity may be taken as a single dose or divided in two doses which are to be taken every 12 hours.

Children who are known to weigh more than 50 kilograms and children who are older than 12 years are usually prescribed by their personal health care provider the adult dose of this medication, which consists in 400mg of drug which should be ingested daily.

As the functions of the kidneys usually decrease with age and as this medicine is eliminated from the organism by the kidneys, the personal health care provider will prescribe the elderly people only a small dose of Zimnic-O (Cefixime).

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Zimnic-O overdose

Patients who believe that they have taken an overdose of Zimnic-O (Cefixime) should immediately announce their doctor. Your personal physician will ask you to remain in the hospital for further tests and symptomatic treatment.

It is well known that any drug which is taken in excess can lead to a series of symptoms. In the case of a Zimnic-O (Cefixime) overdose, the symptoms which a patient can experience include the following: nausea, diarrhea, vomiting, headaches, blood in the urine and upper abdominal pain.

Zimnic-O Missed Dose

Patients are recommended to try to respect the schedule which their doctor gave them and not to skip any dose of Zimnic-O (Cefixime). Individuals, who are supposed to take this medicine once a day and forget to take one of the doses, should take it as soon as they remember; then, they must wait 12 hours before the next dose. After taking the second dose of this product, the patients can return to their normal schedule.

Patients, who are taking Zimnic-O (Cefixime) twice a day and forget to take one of the doses, should take it as soon as they recall and wait at least 6 hours before taking the next dose. After taking the second dose, they can proceed with their normal schedule.

Patients who are taking Zimnic-O (Cefixime) three times a day and forget to take one or more of their scheduled doses, can take a dose of this remedy as soon as they remember, and wait at least 4 hours before taking the next dose; after this they can return to their regular schedule.

Zimnic-O side effects

It is a well known the fact that any medicine has its side effects; in the case of Zimnic-O (Cefixime), the clinical manifestations which can appear include: abdominal pain, gas, indigestion, loose stools, nausea, vomiting and mild diarrhea, headaches, itching, fever, dizziness and inflammation of the large intestine.

Zimnic-O drug reactions

Patients should inform their doctor before beginning their treatment if they are taking Tegretol (which is a seizure medication) or Coumadin (which is an anticlotting medication). Patients should also inform their doctor of all the prescription and non prescription medicines that they are taking, including vitamins and herbal products.

Ofloxacin:


Pharmacological action

Zimnic-O is an antimicrobial agents of broad-spectrum action type from fluoroquinolone group. Bactericidal action of Zimnic-O (Ofloxacin) is due to blockage of the enzyme DNA gyrase in bacterial cells. This medication is highly active against most of gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Mycoplasma spp., Legionella pneumophila, Acinetobacter spp., and Chlamydia spp.

Zimnic-O (Ofloxacin) is active against some gram-positive bacteria (including Staphylococcus spp., Streptococcus spp., especially beta-hemolytic streptococci).

Enterococcus faecalis, Streptococcus pneumoniae, Pseudomonas spp. are moderately susceptible to Zimnic-O (Ofloxacin).

Anaerobic bacteria (except Bacteroides ureolyticus) are insensitive to Zimnic-O (Ofloxacin).

This drug is resistant to beta-lactamases.

Pharmacokinetics

After oral administration Zimnic-O (Ofloxacin) is rapidly and completely absorbed from the gastrointestinal tract. Ingestion has a little effect on the extent of absorption but may slow its speed. Cmax plasma levels reached in 2 hours.

The protein binding is 25%. Zimnic-O (Ofloxacin) is widely distributed in tissues and body fluids (organs of urinary system, reproductive organs, prostate, lung, ENT organs, gall bladder, bone, skin).This medicine is excreted in the urine in unchanged form (about 80% in 24 h). A small portion of the active substance (4%) is excreted in the feces. T1/2 is 6 h.

Why is Zimnic-O prescribed?

Infectious-inflammatory diseases caused by microorganisms sensitive to Zimnic-O (Ofloxacin), including: diseases of the lower respiratory tract, ear, nose, throat, skin, soft tissues, bones, joints, infectious and inflammatory diseases of the abdominal organs (except bacterial enteritis) and pelvic infection, kidney and urinary tract, prostatitis, gonorrhea.

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Dosage and administration

Dosing regimen of Zimnic-O is individual. Daily dose of 200-800 mg, the multiplicity of application 2 times / day. For patients with impaired renal function (creatinine clearance 20-50 ml / min), the first dose is 200 mg, then 100 mg every 24 hours. When CC is less than 20 ml / min, the first dose is 200 mg, then 100 mg every 48 hours.

Zimnic-O (Ofloxacin) side effects, adverse reactions

Digestive system: nausea, vomiting, diarrhea, abdominal pain and cramps, appetite loss, dry mouth, flatulence, gastrointestinal dysfunction, constipation; rarely - liver damage, liver necrosis, jaundice, hepatitis, intestinal perforation, pseudomembranous colitis, bleeding from the gastrointestinal tract, disorders of the oral mucosa, heartburn, elevated liver enzymes, including GGT and LDH, increased serum bilirubin.

CNS and peripheral nervous system: insomnia, dizziness, fatigue, drowsiness, nervousness; rarely - convulsions, anxiety, cognitive changes, depression, abnormal dreams, euphoria, hallucinations, paresthesia, syncope, tremor, confusion, nystagmus, suicidal thoughts or attempts, disorientation, psychotic reactions, paranoia, phobia, agitation, aggressiveness, emotional instability, peripheral neuropathy, ataxia, incoordination, exacerbation of extrapyramidal disorders, speech disorder.

Allergic reactions: skin rash, itching, rarely - angioedema, urticaria, vasculitis, allergic pneumonitis, anaphylactic shock, erythema multiforme, Stevens-Johnson syndrome, erythema nodosum, exfoliative dermatitis, toxic epidermal necrolysis, conjunctivitis.

Sexual system: an itch on the external genitalia in women, vaginitis, vaginal discharge; rare - burning, irritation, pain and rash in the genital area of women, dysmenorrhea, menorrhagia, metrorrhagia, vaginal candidiasis.

Cardiovascular system: rarely - heart failure, edema, hypertension, hypotension, palpitation, vasodilatation, cerebral thrombosis, pulmonary edema, and tachycardia.

Urinary system: rarely - dysuria, urinary frequency, urinary retention, anuria, polyuria formation of kidney stones, kidney failure, nephritis, hematuria, albuminuria, candiduria.

Musculoskeletal system: rarely - arthralgia, myalgia, tendonitis, muscle weakness, exacerbation of myasthenia gravis.

Metabolism: rarely - thirst, weight loss, hyper- or hypoglycemia (especially in patients with diabetes mellitus receiving insulin or oral hypoglycemic agents), acidosis, increase in serum triglycerides, cholesterol, potassium.

Respiratory system: rarely - cough, runny nose, respiratory failure, dyspnea, bronchospasm, stridor.

Sensory organs: rarely - hearing loss, tinnit, diplopia, nystagmus, impaired clarity of vision, disturbances of taste, smell, photophobia.

Dermatological reactions: rarely - photosensitivity, hyperpigmentation, vesicle-bullous eruption.

Hematopoietic system: rarely - anemia, hemorrhage, pancytopenia, agranulocytosis, leukopenia, reversible suppression of bone marrow hematopoiesis, thrombocytopenia, thrombocytopenic purpura, petechiae, ecchymosis, increased prothrombin time.

Other: chest pain, sore throat, fever, body aches, rarely - fatigue, chills, malaise, epistaxis, increased sweating.

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Zimnic-O contraindications

Pregnancy, lactation, childhood and adolescence to 18 years, increased sensitivity to Zimnic-O (Ofloxacin) or other quinolone derivatives.

Using during pregnancy and breastfeeding

Zimnic-O is contraindicated during pregnancy and lactation.

Category effects on the fetus by FDA - C.

Special instructions

Use with caution in patients with impaired renal function and liver.

During the period of treatment required to conduct monitoring of blood glucose. Long-term therapy is necessary to periodically monitor the kidney function, liver and peripheral blood picture.

When using Zimnic-O (Ofloxacin) it should be ensure adequate hydration of the body, the patient should be subjected to ultraviolet irradiation.

In experimental studies the mutagenic potential was not been identified. Long-term studies to determine the carcinogenicity of Zimnic-O (Ofloxacin) were not conducted.

Safety and efficacy in children and adolescents under the age of 18 is not defined.

Use with caution in patients whose activities are connected with the necessity of high concentration of attention and quickness of psychomotor reactions.

Zimnic-O drug interactions

Simultaneous administration of Zimnic-O (Ofloxacin) with:

  • antacids containing calcium, magnesium or aluminum, with sucralfate, with preparations containing two-and trivalent cations, such as iron, or multivitamins containing zinc it may be in breach absorption of quinolones, resulting in a decrease in their concentration in the body. These medications should not be used for 2 hours before or within 2 hours after taking Zimnic-O (Ofloxacin).
  • NSAIDs increases the risk of stimulating effect on the central nervous system and seizures.
  • theophylline may increase its concentration in blood plasma (including the equilibrium state), increasing half-life. This increases the risk of adverse reactions associated with the action of theophylline.
  • beta-lactam antibiotics, aminoglycosides and metronidazole there were observed additive interaction.

    Zimnic-O in case of emergency / overdose

    Symptoms: drowsiness, nausea, vomiting, dizziness, disorientation, lethargy, confusion.

    Treatment: gastric lavage, maintenance of vital functions.

  • Zimnic-O pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Zimnic-O available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Zimnic-O destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Zimnic-O Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Zimnic-O pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."SUPRAX (CEFIXIME) CAPSULE [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."OFLOXACIN SOLUTION [BAUSCH & LOMB INCORPORATED]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."OFLOXACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Zimnic-O?

    Depending on the reaction of the Zimnic-O after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zimnic-O not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Zimnic-O addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Zimnic-O, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Zimnic-O consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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