DRUGS & SUPPLEMENTS
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Zebrak is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Zebrak lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.
After oral administration Cmax of Zebrak in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Zebrak are linear. Css in the plasma is established within 1-2 weeks of therapy.
Binding to plasma proteins is less than 80%.
In blood plasma Zebrak is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.
T1/2 is 1.5 days.
Zebrak is excreted by the kidneys and the bowel.
Depression of various etiologies, panic disorder, obsessive-compulsive disorder.
Zebrak is taken oral 1 time / day.
For adults depending on the evidence the initial dose of Zebrak is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.
Digestive system: frequently - dry mouth, nausea.
CNS: frequently - drowsiness, tremor, and in rare cases - seizures.
Cardiovascular system: possible slight decrease in heart rate.
Other: often - increased sweating.
Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.
Hypersensitivity to Zebrak; simultaneous taking MAO inhibitors.
Safety of Zebrak during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.
In experimental studies there was revealed no teratogenic effects and any effect of Zebrak on reproduction and prenatal development of the fetus.
In patients with liver failure Zebrak should be used in minimal doses.
At weak and moderate renal insufficiency it does not require correction of dosing regimen of Zebrak Meliapharm, the information on the application in severe renal failure is absent.
During the treatment period with Zebrak it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Zebrak may cause a more pronounced bradycardia.
The efficacy and safety of Zebrak in children has not been established.
Zebrak should not be used concurrently with MAO inhibitors.
Patients should be prescribed with care for Zebrak in highest dose and high doses of cimetidine.
It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.
Simultaneous administration of Zebrak with:
The effects of sumatriptan and other serotonergic medications can be amplified by Zebrak in their simultaneous application.
Symptoms: dizziness, sweating, nausea, vomiting, tremor, somnolence, sinus tachycardia. In more rare cases - amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, ECG changes.
Treatment: gastric lavage and use of activated carbon. Maintaining an airway to ensure adequate ventilation and oxygenation. It is recommended careful observation and monitoring of vital functions. Due to the large volume of distribution of Zebrak is unlikely efficiency such measures as forced diuresis, dialysis, hemoperfusion and exchange transfusion. There is no specific antidote.
Depending on the reaction of the Zebrak after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Zebrak not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Zebrak addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology