Vintram-P

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Vintram-P uses

Vintram-P consists of Acetaminophen, Tramadol Hydrochloride.

Acetaminophen:


Pharmacological action

Vintram-P is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Vintram-P (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Vintram-P dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Vintram-P side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Vintram-P, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Vintram-P (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Vintram-P (Acetaminophen) on the fetus in humans.

Vintram-P (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Vintram-P (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Vintram-P (Acetaminophen).

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Special Instructions

Vintram-P is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Vintram-P (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Vintram-P (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Vintram-P (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Vintram-P (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Vintram-P (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Vintram-P (Acetaminophen).

When Vintram-P (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Vintram-P (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Vintram-P (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Vintram-P (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Vintram-P (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Vintram-P (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Vintram-P (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Vintram-P (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Vintram-P (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Vintram-P (Acetaminophen) with ethinylestradiol increases absorption of Vintram-P (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Vintram-P in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Tramadol Hydrochloride:


Pharmacological action

Vintram-P Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Vintram-P (Tramadol Hydrochloride) is a racemate (+) and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.

Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Vintram-P (Tramadol Hydrochloride) has also an antitussive effect.

Pharmacokinetics

After oral administration Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). Cmax in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.

Plasma protein binding is 20%. Vintram-P (Tramadol Hydrochloride) is widely distributed in tissues. Vd after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.

Vintram-P (Tramadol Hydrochloride) metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.

This medicine excreted by the kidneys - 90% and through the intestines - 10%.

Why is Vintram-P Karnataka Antibiotics & Pharmaceuticals prescribed?

Moderate and severe pain of various origins (including malignant tumors, acute myocardial infarction, disease, trauma). Conducting painful diagnostic or therapeutic procedures.

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Dosage and administration

A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.

For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.

The duration of treatment is determined individually.

The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.

Vintram-P Karnataka Antibiotics & Pharmaceuticals side effects, adverse reactions

CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin (for IV uses in high doses or with concomitant administration of neuroleptics).

Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.

Digestive system: dry mouth, nausea, vomiting.

Metabolism: increased sweating.

Musculoskeletal system: miosis.

Vintram-P Karnataka Antibiotics & Pharmaceuticals contraindications

  • acute intoxication with alcohol and drugs, providing a depressing effect on the CNS
  • children up to age 1 year
  • hypersensitivity to Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals

    Using during pregnancy and breastfeeding

    During pregnancy patients should avoid prolonged use of Vintram-P Karnataka Antibiotics & Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.

    If necessary using in lactation (breastfeeding) should be aware that Vintram-P (Tramadol Hydrochloride) in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.

    Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.

    Patients need to avoid combination with MAO inhibitors.

    During the period of treatment with Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals you should avoid to take alcohol.

    Vintram-P (Tramadol Hydrochloride) in the form of long-acting formulations should not be used in children under the age of 14 years.

    During the period of Vintram-P (Tramadol Hydrochloride) using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.

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    Special instructions

    With caution Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals should be used in convulsions of central genesis of drug dependence, confusion, patients with impaired renal function and liver, as well as increased sensitivity to other opioid receptor agonists.

    Vintram-P (Tramadol Hydrochloride) should not be used beyond the period justified from a therapeutic point of view.

    Vintram-P Karnataka Antibiotics & Pharmaceuticals drug interactions

    Simultaneous administration of Vintram-P (Tramadol Hydrochloride) Karnataka Antibiotics & Pharmaceuticals with:

  • drugs providing a depressing effect on the CNS or with ethanol may increase the CNS depressant effects of Vintram-P (Tramadol Hydrochloride);
  • MAO inhibitors are likely development of serotonin syndrome;
  • serotonin reuptake inhibitors, tricyclic antidepressants, antipsychotics, other means of reducing the threshold of convulsive readiness, increases the risk of seizures;
  • warfarin and phenprocoumon increase anticoagulant effect;
  • carbamazepine reduced the concentration of Vintram-P (Tramadol Hydrochloride) in plasma and its analgesic effect;
  • paroxetine describes cases of serotonin syndrome, seizures;
  • sertraline, fluoxetine describes cases of serotonin syndrome;
  • opioid analgesics is likely to reduce the analgesic action. Prolonged use of opioid analgesics or barbiturates stimulates the development of cross-tolerance;
  • naloxone activates respiration, eliminating analgesia after opioid analgesics.

    Vintram-P Karnataka Antibiotics & Pharmaceuticals in case of emergency / overdose

    Symptoms: respiratory depression, until apnea, seizures, Pupillary, anuria, coma.

    Treatment: IV injection of naloxone (a specific antagonist), gastric lavage, maintenance of vital functions.

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    Vintram-P pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Vintram-P available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Vintram-P destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Vintram-P Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Vintram-P pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."TRAMADOL HYDROCHLORIDE TABLET [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Vintram-P?

    Depending on the reaction of the Vintram-P after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Vintram-P not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Vintram-P addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Vintram-P, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Vintram-P consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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