Victadol-P

Acetaminophen:

• Pharmacological action
• Why is Victadol-P (Acetaminophen) prescribed?
• Victadol-P dosage and administration
• Victadol-P side effects, adverse reactions
• Contraindications
• Using during pregnancy and breastfeeding
• Special Instructions
• Victadol-P (Acetaminophen) Drug Interactions
• Victadol-P in case of emergency / overdose
• Victadol-P (Acetaminophen) reviews

Pharmacological action

Victadol-P is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Victadol-P (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Victadol-P dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Victadol-P side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Victadol-P, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Victadol-P (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Victadol-P (Acetaminophen) on the fetus in humans.

Victadol-P (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Victadol-P (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Victadol-P (Acetaminophen).

Special Instructions

Victadol-P is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Victadol-P (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Victadol-P (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Victadol-P (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Victadol-P (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Victadol-P (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Victadol-P (Acetaminophen).

When Victadol-P (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Victadol-P (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Victadol-P (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Victadol-P (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Victadol-P (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Victadol-P (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Victadol-P (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Victadol-P (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Victadol-P (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Victadol-P (Acetaminophen) with ethinylestradiol increases absorption of Victadol-P (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Victadol-P in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Tramadol:

• Pharmacological action
• Pharmacokinetics
• Why is Victadol-P Karnataka Antibiotics & Pharmaceuticals prescribed?
• Dosage and administration
• Victadol-P Karnataka Antibiotics & Pharmaceuticals side effects, adverse reactions
• Victadol-P Karnataka Antibiotics & Pharmaceuticals contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Victadol-P Karnataka Antibiotics & Pharmaceuticals drug interactions
• Victadol-P Karnataka Antibiotics & Pharmaceuticals in case of emergency / overdose
• Victadol-P (Tramadol) reviews

Pharmacological action

Victadol-P Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Victadol-P (Tramadol) is a racemate (+) and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.

Victadol-P (Tramadol) Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Victadol-P (Tramadol) has also an antitussive effect.

Pharmacokinetics

After oral administration Victadol-P (Tramadol) Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). C_max in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.

Plasma protein binding is 20%. Victadol-P (Tramadol) is widely distributed in tissues. V_d after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.

Victadol-P (Tramadol) metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.

This medicine excreted by the kidneys - 90% and through the intestines - 10%.

Why is Victadol-P Karnataka Antibiotics & Pharmaceuticals prescribed?

Moderate and severe pain of various origins (including malignant tumors, acute myocardial infarction, disease, trauma). Conducting painful diagnostic or therapeutic procedures.

Dosage and administration

A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.

For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.

The duration of treatment is determined individually.

The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.

Victadol-P Karnataka Antibiotics & Pharmaceuticals side effects, adverse reactions

CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin (for IV uses in high doses or with concomitant administration of neuroleptics).

Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.

Digestive system: dry mouth, nausea, vomiting.

Metabolism: increased sweating.

Musculoskeletal system: miosis.

Victadol-P Karnataka Antibiotics & Pharmaceuticals contraindications