|
|||
|
DRUGS & SUPPLEMENTS
|
Tranavan
How old is patient? |
Tranavan uses
Pharmacological action
Tranavan is an anxiolytic drug, a derivative of benzodiazepine. This medication has anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant central, antiemetic effect. The mechanism of the anxiolytic, sedative and hypnotic action is associated with increased inhibitory effect of GABA in the CNS. Anticonvulsant action, apparently in part due to increased presynaptic inhibition; inhibited the spread of epileptogenic activity arising in the epileptogenic foci in the cortex, thalamus and limbic structures, but not removed the excited state of the hearth. Muscle relaxant effect is primarily associated with the suppression of spinal polysynaptic afferent pathways and, presumably, an inhibition of monosynaptic afferent pathways; possibly also a direct inhibitory effect on motor nerves and muscle function.
Pharmacokinetics
After oral administration the bioavailability of Tranavan is 95-99%. The plasma proteins binding is about 80%. Vd is 1.3 L / kg. Tranavan is metabolized in the liver by conjugation to form inactive metabolites. T1/2 is 8-15 h. This medicine is derived primarily by the kidneys.
Why is Tranavan prescribed?
Anxiety, sleep disturbances due to anxiety or transient stressful situation, neuroses and neurosis-like states, panic disorder, endogenous psychoses: mania, catatonic state, anxiety and excitement in schizophrenia; acute alcoholic delirium; premedication in anesthesia, epilepsy (in combination therapy), status epilepticus; symptomatic convulsive status; psychosomatic disorders and headaches.
Dosage and administration
For oral administration for adults and adolescents the dose is 0.5-4 mg 1-3 times / day. In IV or IM introduction a single dose is 50 mg / kg, the dose frequency is set depending on the evidence and the clinical situation.
The maximum daily dose when Tranavan administered orally is 10 mg, for IV and IM injections a single dose is 4 mg.
Tranavan side effects, adverse reactions
CNS: rarely - dizziness, ataxia, fatigue, muscle weakness; in some cases - the episodes of amnesia.
Digestive system: rarely - dry mouth, dysphagia, nausea, diarrhea, constipation, appetite disorders; in some cases - liver function abnormalities.
Allergic reactions: rarely - skin rash, itching.
Laboratory parameters: changes in peripheral blood.
Local reactions: for IV injections can be phlebitis or venous thrombosis.
Tranavan contraindications
Myasthenia gravis, angle-closure glaucoma, acute intoxication with psychotropic drugs, acute alcohol intoxication, increased sensitivity to Tranavan.
Using during pregnancy and breastfeeding
During pregnancy, especially in the I trimester, apply Tranavan only under strict indications. Tranavan and / or its metabolites are excreted in breast milk. provision. It should be borne in mind that newborns benzodiazepines metabolized more slowly than adults, therefore it is possible accumulation of the active substance and / or its metabolites in the body of the child.
Special instructions
With extreme caution Tranavan is used in closed-angle glaucoma is suspected, severe chronic obstructive pulmonary disease, in a coma, shock, epilepsy, renal dysfunction, hyperkinesis, hypoproteinemia, severe depression, organic brain disease, porphyria, psychosis with suspected sleep apnea.
The development of adverse reactions are more likely at the beginning of treatment and in cases of exceeding the recommended doses.
With prolonged use of Tranavan may develop addiction and drug dependence.
In the case of using this medication for sedation it may be required reducing the dose of fentanyl derivative used for induction of anesthesia, and it is possible a reduction of time before the mind with induction doses.
Patients receiving Tranavan should refrain from activities in potentially hazardous activities that require attention and psychomotor speed of reaction.
Tranavan drug interactions
When this drug applied simultaneously with:
- drugs which have a depressing effect on the CNS, with alcohol, alcohol containing drugs increased inhibitory effect on the CNS.
- Tranavan and alcohol may develop agitation, aggression, pathological intoxication.
- diminishes the effectiveness of oral contraceptives.
- enhanced effect of depolarizing relaxants.
- nicotine increases the metabolism of Tranavan, and decreases its activity.
- probenecid may interfere with the binding of Tranavan with glucuronic acid, resulting in higher concentrations in blood plasma, and by enhancing the therapeutic effect may develop excessive sedation.
Tranavan in case of emergency / overdose
Symptoms: drowsiness, hypotension, confusion, depression of reflexes, coma.
Treatment: induction of vomiting, gastric lavage, IV introduction of norepinephrine to increase blood pressure, symptomatic therapy, monitoring of vital functions. The introduction of a specific antidote - an antagonist of benzodiazepine receptors flumazenil (in hospital).
Tranavan pharmaceutical active ingredients containing related brand and generic drugs:
Tranavan available forms, composition, doses:
Tranavan destination | category:
Tranavan Anatomical Therapeutic Chemical codes:
Tranavan pharmaceutical companies:
References
- Dailymed."LORAZEPAM CONCENTRATE [AMNEAL PHARMACEUTICALS, LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."LORAZEPAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "lorazepam". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Tranavan?Depending on the reaction of the Tranavan after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tranavan not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Tranavan addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Tranavan, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Tranavan consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
One visitor reported useful
How is the drug Tranavan useful in reducing or relieving the symptoms? How useful is it?According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
| Visitors | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
Visitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetFour visitors reported frequency of use
How often in a day do you take the medicine?Are you taking the Tranavan drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Tranavan is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 3 | 75.0% | |
| Twice in a day | 1 | 25.0% | |
Eight visitors reported doses
What is the dose of Tranavan drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 1-5mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 1-5mg | 7 | 87.5% | |
| 11-50mg | 1 | 12.5% | |
Two visitors reported time for results
What is the time duration Tranavan drug must be taken for it to be effective or for it to reduce the symptoms?Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Tranavan drug. The time needed to show improvement in health condition after using the medicine Tranavan need not be same for all the users. It varies based on other factors.
| Visitors | % | ||
|---|---|---|---|
| 1 day | 2 | 100.0% | |
One visitor reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Tranavan drug, before food or after food?Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
| Visitors | % | ||
|---|---|---|---|
| Empty stomach | 1 | 100.0% | |
Nine visitors reported age
| Visitors | % | ||
|---|---|---|---|
| > 60 | 6 | 66.7% | |
| 30-45 | 3 | 33.3% | |
Visitor reviews
| Tranavan as prescribed in Thailand is nothing like as good as Lorazepam. It tranquilizes but does not help at all as an anti-depressant. |
The information was verified by Dr. Rachana Salvi, MD Pharmacology