DRUGS & SUPPLEMENTS
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Tralgiol Karnataka Antibiotics & Pharmaceuticals is an opioid analgesic, a derivative of cyclohexanol. It is non-selective agonist of mu-, delta- and kappa-receptors in the CNS. Tralgiol is a racemate and (-) of isomers (50% / 50%) which in various ways are involved in analgesic effects. The isomer (+) is a pure agonist opioid receptors, it has low tropism and has a pronounced selectivity for different subtypes of receptors. The isomer (-) inhibiting neuronal capture of noradrenaline activates the descending noradrenergic influence. Thats why it is broken transmission of pain impulses in the gelatinous substance of spinal cord.
Tralgiol Karnataka Antibiotics & Pharmaceuticals causes sedation. At therapeutic doses this medication almost not get respiratory depression. Tralgiol has also an antitussive effect.
After oral administration Tralgiol Karnataka Antibiotics & Pharmaceuticals quickly and almost completely absorbed from the gastrointestinal tract (90%). Cmax in plasma obtained in 2 h after taking this medication. Bioavailability in single dose is 68% and increases with repeated use.
Plasma protein binding is 20%. Tralgiol is widely distributed in tissues. Vd after oral administration and intravenous injection is 306 l and 203 l respectively. This drug crosses the placental barrier in a concentration equal to the concentration of the active substance in the plasma. 0.1% is excreted in breast milk.
Tralgiol metabolised by demethylation and conjugation to 11 metabolites, of which only 1 is active.
This medicine excreted by the kidneys - 90% and through the intestines - 10%.
Moderate and severe pain of various origins. Conducting painful diagnostic or therapeutic procedures.
A single oral dose for adults and children over 14 years is 50 mg, rectally - 100 mg, IV slowly or IM - 50-100 mg. If for parenteral injection efficiency is not enough, it is possible oral taking in a dose of 50 mg after 20-30 minutes.
For children aged 1 to 14 years set the dose rate of 1-2 mg / kg.
The duration of treatment is determined individually.
The maximum dose for adults and children over 14 years regardless of method of administration is 400 mg / day.
CNS: dizziness, weakness, drowsiness, confusion, and in some cases - seizures and convulsions of cerebral origin.
Cardio-vascular system: tachycardia, orthostatic hypotension, collapse.
Digestive system: dry mouth, nausea, vomiting.
Metabolism: increased sweating.
Musculoskeletal system: miosis.
During pregnancy patients should avoid prolonged use of Tralgiol Karnataka Antibiotics & Pharmaceuticals because the risk of addiction in the fetus and the occurrence of withdrawal in the neonatal period.
If necessary using in lactation should be aware that Tralgiol in small amounts excreted in breast milk. In the case of long-term treatment can not been excluded the possibility of drug dependence.
Tralgiol Karnataka Antibiotics & Pharmaceuticals is not recommended for treatment of withdrawal syndrome drugs.
Patients need to avoid combination with MAO inhibitors.
During the period of treatment with Tralgiol Karnataka Antibiotics & Pharmaceuticals you should avoid to take alcohol.
Tralgiol in the form of long-acting formulations should not be used in children under the age of 14 years.
During the period of Tralgiol using is not recommended to engage in activities that require special attention, speed of psychomotor reactions.
With caution Tralgiol Karnataka Antibiotics & Pharmaceuticals should be used in convulsions of central genesis of drug dependence, confusion, patients with impaired renal function and liver, as well as increased sensitivity to other opioid receptor agonists.
Tralgiol should not be used beyond the period justified from a therapeutic point of view.
Simultaneous administration of Tralgiol Karnataka Antibiotics & Pharmaceuticals with:
Symptoms: respiratory depression, until apnea, seizures, Pupillary, anuria, coma.
Treatment: IV injection of naloxone (a specific antagonist), gastric lavage, maintenance of vital functions.
Depending on the reaction of the Tralgiol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Tralgiol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Tralgiol addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology