|
|||
|
DRUGS & SUPPLEMENTS
|
Thelmox
What are the side effects you encounter while taking this medicine? |
Thelmox uses
Pharmacological action
Thelmox is a worming medication a broad spectrum of action, it is most effective when enterobioze. This drug causes irreversible disturbance of glucose utilization in the body of the worm and inhibits the synthesis of ATP.
Pharmacokinetics
Thelmox is practically not absorbed from the gastrointestinal tract. The plasma protein binding is 90%. This medication is distributed unevenly in organs and accumulates in adipose tissue, liver, and larvae of helminths. Thelmox is metabolized in the liver to 2-amino derivative.
T1/2 is 2.5-5.5 hours. More than 90% of the dose is excreted unchanged in feces. Grown deep portion is excreted by kidneys.
Why is Thelmox prescribed?
Enterobiasis, ascariasis, hookworm disease, strongyloidiasis, trichuriasis, trichinosis, teniasis, echinococcosis, mixed helminth infections.
Dosage and administration
For adults and children over 10 years at enterobioze a single dose is 100 mg.
For children aged 2 to 10 years a single dose is 25-50 mg. In the case of a high probability of re-infestation the drug taking repeats after 2-4 weeks in the same dose.
It is recommended that simultaneous treatment of all family members.
When ascariasis, trichuriasis, hookworm disease, teniasis, strongyloidiasis and mixed helminthiasis - 100 mg in the morning and evening for 3 days. When trichinosis - 200-400 mg 3 times / day for 3 days, from 4th to 10th day - 400-500 mg 3 times / day. When echinococcosis - 500 mg 2 times / day in the first 3 days, then the same dose 3 times / day in the next 3 days. Later Thelmox used in doses of 25-30 mg / kg / day in 3-4 doses.
Thelmox side effects, adverse reactions
Digestive system: rarely - nausea, abdominal pain; when used in high doses for long periods of time may be vomiting, diarrhea, transient elevation of liver enzymes in serum.
CNS: Rarely - dizziness when used in high doses for long periods of time - a headache.
Hematopoietic system: when used in high doses for long periods of time may be leukopenia, anemia, eosinophilia.
Urinary system: when used in high doses for long periods of time - hematuria, cylindruria.
Other: when used in high doses for long periods of time - an allergic reaction, hair loss.
Thelmox contraindications
Pronounced liver disfunctions, pregnancy, lactation, children under 2 years of age, hypersensitivity to Thelmox.
Using during pregnancy and breastfeeding
Thelmox is contraindicated during pregnancy and lactation (breastfeeding).
Category of the fetus by FDA - C.
Special instructions
With prolonged use of Thelmox it is necessary to control the peripheral blood picture, liver and kidney function.
Within days after taking Thelmox avoid drinking alcohol.
After receiving Thelmox do not use a laxative.
It is mandatory a periodic examination of smears of the anal region and the feces after treatment.
Thelmox drug interactions
Thelmox reduces insulin requirements in diabetic patients.
It is necessary to avoid a simultaneously taking of Thelmox with lipophilic substances. With simultaneous use with cimetidine it may increase, and carbamazepine, and other inducers of metabolism to reduce the concentration of Thelmox in the blood.
Thelmox in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea, abdominal pain. With prolonged use at high doses: reversible hepatic dysfunction, hepatitis, neutropenia.
Treatment: gastric lavage, enemas, activated charcoal method; there is no specific antidote.
Thelmox pharmaceutical active ingredients containing related brand and generic drugs:
Thelmox available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.