DRUGS & SUPPLEMENTS

Teva-Ranitidine

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Teva-Ranitidine uses


Pharmacological action

Teva-Ranitidine is a blocker of histamine H2-receptors. Inhibits basal and stimulated by histamine, gastrin and acetylcholine the secretion of hydrochloric acid. Increases the pH of gastric contents and reduces the activity of pepsin. The duration of action of Teva-Ranitidine with a single admission - 12 hours.

Pharmacokinetics

After oral administration, Teva-Ranitidine is rapidly absorbed from the gastrointestinal tract. Eating and antacids significantly affect the extent of absorption. Subjected to the effect of "first passage" through the liver. Cmax in plasma is reached within 2 h after a single oral administration. After IM injection Teva-Ranitidine rapidly and almost completely absorbed from the injection site. Cmax achieved within 15 min.

Protein binding - 15%. Vd - 1.4 L / kg. Teva-Ranitidine is excreted in breast milk.

T1/2 is 2-3 h. About 30% of the dose excreted in the urine in unchanged form. Elimination rate decreases with abnormal liver function or renal function.

Why is Teva-Ranitidine prescribed?

Gastric ulcer and duodenal ulcer in acute phase; prevention of relapse of peptic ulcer; symptomatic ulcer; erosive and reflux esophagitis; Zollinger-Ellison syndrome; prevention of "stress" ulcers of the gastrointestinal tract, postoperative ulcers, recurrent bleeding from upper gastrointestinal tract; prevention of aspiration of gastric juice during operations under general anesthesia.

Dosage and administration

Individual. For oral administration for treatment of adults and children over 14 years daily Teva-Ranitidine dose is 300-450 mg; if necessary, the daily dose was increased to 600-900 mg; multiplicity of administration is 2-3 times / day. For the prevention of exacerbations of disease are used by 150 mg / day at bedtime. The duration of treatment is determined by the indications for use.

The dose of Teva-Ranitidine for patients with renal insufficiency at the level of creatinine more than 3.3 mg / 100 ml is 75 mg 2 times / day.

IV or IM by 50-100 mg every 6-8 hours.

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Teva-Ranitidine side effects, adverse reactions

Cardio-vascular system: in a few cases - AV-blockade.

Digestive system: rarely - diarrhea, constipation, and in isolated cases - hepatitis.

CNS: Rarely - headache, dizziness, fatigue, blurred vision, and in isolated cases (at seriously ill patients) - confusion, hallucinations.

Hematopoietic system: rarely - thrombocytopenia, prolonged use at high doses - leukopenia.

Metabolism: rarely - a slight increase of creatinine in serum at the beginning of treatment.

Endocrine system: long-term use in high doses may increase the content of prolactin, gynecomastia, amenorrhea, impotence, decreased libido.

From the musculoskeletal system: very rarely - arthralgia, myalgia.

Allergic reactions: rarely - a skin rash, urticaria, angioedema, anaphylactic shock, bronchospasm, hypotension.

Other: rarely - recurrent parotitis, and in isolated cases - hair loss.

Teva-Ranitidine contraindications

Pregnancy, lactation (breastfeeding), increased sensitivity to Teva-Ranitidine.

Using during pregnancy and breastfeeding

Adequate and well controlled studies of the safety of Teva-Ranitidine during pregnancy has not been conducted, therefore the use during pregnancy is contraindicated.

If necessary the use of Teva-Ranitidine during lactation should stop breastfeeding.

Special instructions

With careful use in patients with impaired renal excretory function.

Before treatment with Teva-Ranitidine is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.

With long-term treatment of debilitated patients under stress conditions may be bacterial lesions of the stomach with subsequent spread of infection.

Undesirable abrupt discontinuation of Teva-Ranitidine because of the risk of recurrence of peptic ulcer. Effectiveness of prophylactic treatment of peptic ulcer above while taking Teva-Ranitidine courses for 45 days in spring and autumn than during the reception. Quick intravenous injection of Teva-Ranitidine in rare cases cause bradycardia, usually in patients predisposed to cardiac arrhythmias.

There are a few reports that Teva-Ranitidine might contribute to the development of acute attacks of porphyria, in connection with what is necessary to avoid its use in patients with acute porphyria in history.

Therapy with Teva-Ranitidine possible distortions of laboratory data: increased creatinine, the activity of gamma-glutamyl transpeptidase and liver transaminases in the blood plasma.

In cases where Teva-Ranitidine is used in combination with antacids, the break between taking antacids and Teva-Ranitidine should be at least 1-2 hours.

Clinical data on the safety of Teva-Ranitidine in pediatric patients is limited.

Teva-Ranitidine drug interactions

In an application with antacids may decrease absorption of Teva-Ranitidine.

In an application of Teva-Ranitidine with anticholinergics may be in breach of memory and attention in elderly patients.

Probably that histamine H2-blockers reduce receptor ulcerogenic action of NSAIDs on the gastric mucosa.

In an application with warfarin may decrease clearance of warfarin. There is one case of gipoprotrombinemiey and bleeding in patients receiving warfarin.

In an application with bismuth tripotassium dicitrate may increase unwanted absorption of bismuth, with glyburide - described the cases of hypoglycemia, with ketoconazole, itraconazole - decreased absorption of ketoconazole, itraconazole.

In an application with metoprolol may increase the plasma concentrations and increased AUC and T1 / 2 of metoprolol.

In an application with sucralfate in high doses (2 g) possible violation of the absorption of Teva-Ranitidine.

In an application Teva-Ranitidine with procainamide may be decrease excretion of procainamide by the kidneys which leads to an increase in its concentration in blood plasma.

There is a data of increased absorption of triazolam in its simultaneous application, apparently due to changes in pH of gastric contents under the influence of Teva-Ranitidine.

Probably that while the application with phenytoin may increase the concentration of phenytoin in plasma and increased risk of toxicity.

In an application with furosemide moderately expressed increasing the bioavailability of furosemide.

There is a described case of ventricular arrhythmias (bigeminy) with simultaneous application of quinidine, with cisapride - described a case of cardiotoxicity.

It can not be excluded some increase in cyclosporine concentration in blood plasma in its simultaneous application with Teva-Ranitidine.

Teva-Ranitidine in case of emergency / overdose

Symptoms: seizures, bradycardia, ventricular arrhythmias.

Treatment: induction of vomiting or gastric lavage, symptomatic therapy. In convulsions - diazepam IV, bradycardia - atropine, ventricular arrhythmias - lidocaine.

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Teva-Ranitidine pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Teva-Ranitidine available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Teva-Ranitidine destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Teva-Ranitidine Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Teva-Ranitidine pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."ZANTAC (RANITIDINE HYDROCHLORIDE) INJECTION, SOLUTION [TELIGENT PHARMA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "ranitidine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
  3. "ranitidine". http://www.drugbank.ca/drugs/DB0086... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Teva-Ranitidine?

Depending on the reaction of the Teva-Ranitidine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Teva-Ranitidine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Teva-Ranitidine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Teva-Ranitidine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Teva-Ranitidine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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