Tesofan-J

Dextromethorphan:

• Pharmacological action
• Pharmacokinetics
• Why is Tesofan-J prescribed?
• Dosage and administration
• Tesofan-J (Dextromethorphan) side effects, adverse reactions
• Tesofan-J contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Tesofan-J drug interactions
• Tesofan-J in case of emergency / overdose
• Tesofan-J (Dextromethorphan) reviews

Pharmacological action

Tesofan-J is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Tesofan-J (Dextromethorphan) has not addiction effects and it has no analgesic and hypnotic action. Tesofan-J (Dextromethorphan) starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Tesofan-J (Dextromethorphan) is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Tesofan-J (Dextromethorphan) used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (ALS) (Charcot's disease), disease of "mad cow and other prion diseases. Tesofan-J (Dextromethorphan) has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.

Pharmacokinetics

After oral administration Tesofan-J (Dextromethorphan) is completely absorbed from the gastrointestinal tract. C_max of Tesofan-J (Dextromethorphan) in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.

Why is Tesofan-J prescribed?

Dry cough of different etiology.

Dosage and administration

For adults and children over 12 years Tesofan-J prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.

Tesofan-J (Dextromethorphan) side effects, adverse reactions

Drowsiness, nausea, dizziness.

Tesofan-J contraindications

Bronchial asthma, bronchitis, simultaneous reception of mucolytic.

Using during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding) Tesofan-J (Dextromethorphan) prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.

Special instructions

With carefully administered Tesofan-J (Dextromethorphan) with impaired liver function.

Tesofan-J drug interactions

MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Tesofan-J (Dextromethorphan) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Tesofan-J (Dextromethorphan) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.

Tesofan-J in case of emergency / overdose

Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.

Treatment: mechanical ventilation, symptomatic agents.

Diphenhydramine:

• Pharmacological action
• Pharmacokinetics
• Why is Tesofan-J Xepa-Soul Pattinson prescribed?
• Dosage and administration
• Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson side effects, adverse reactions
• Tesofan-J Xepa-Soul Pattinson contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Precautionary measures
• Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson drug interactions
• Tesofan-J Xepa-Soul Pattinson in case of emergency / overdose
• Tesofan-J (Diphenhydramine) reviews

Pharmacological action

Tesofan-J Xepa-Soul Pattinson is a blocker of histamine H1-receptors. It has antiallergic activity, has a local anesthetic, antispasmodic and mild ganglion blocking action.

When Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson administered orally Tesofan-J (Diphenhydramine) has a sedative and hypnotic effects, has a moderate antiemetic effect and has a central holinoliticheskoy activity.

When applied externally it has antiallergic effect.

Pharmacokinetics

Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson is rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. C_max is achieved after 20-40 min (in the greatest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Binding to plasma proteins - 98-99%. Penetrates through the BBB. Metabolised mainly in the liver, partly - in the lungs and kidneys. T1/2 is 4-10 hours. Within one day completely removed kidneys as metabolites conjugated to glucuronic acid. Significant quantities are derived from milk and can cause sedation in infants (may be a paradoxical reaction characterized by hyperexcitability).

Why is Tesofan-J Xepa-Soul Pattinson prescribed?

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, Henoch-Schonlein purpura, serum sickness, itchy dermatitis, sleep disorders (monotherapy or in combination with drugs), chorea, sea and air sickness, vomiting in pregnancy, Meniere's syndrome, premedication.

Dosage and administration

Oral, IV, IM, rectal, topical, intranasal, in the conjunctival sac. Oral dose of Tesofan-J Xepa-Soul Pattinson for adults is 30-50 mg 1-3 times / day. The treatment course is 10-15 days. As soporific - 50 mg at bedtime. IM in doses of 50-250 mg; IV in drip - 20-50 mg. When oral administered single dose for children under 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; of 6 to 12 years - 15-30 mg. Externally applied 1-2 times / day.

Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson side effects, adverse reactions

Possible: a short-term numbness in the oral mucosa, drowsiness, weakness, decrease in psychomotor speed of reaction in children may be a paradoxical development of insomnia, irritability, and euphoria.

Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, paresis of accommodation, poor coordination of movements, tremor.

Tesofan-J Xepa-Soul Pattinson contraindications

Closure glaucoma, prostatic hypertrophy, stenosing peptic ulcer, stenosis of the bladder neck, bronchial asthma, epilepsy, hypersensitivity to Tesofan-J (Diphenhydramine).

Using during pregnancy and breastfeeding

During pregnancy and lactation, Tesofan-J (Diphenhydramine) used with caution, according to strict indications, when the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

Special instructions

With careful use Tesofan-J (Diphenhydramine) during pregnancy and lactation.

During the period of treatment with Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson should not be exposed to solar radiation should be avoided alcohol.

Used with caution in patients involved in potentially dangerous activities requiring attention and rapid psychomotor reactions.

Precautionary measures

Tesofan-J Xepa-Soul Pattinson is not recommended for SC injection. Since Tesofan-J (Diphenhydramine) has atropinopodobnym action should be cautious in its use: patients with recent respiratory infection in history (including asthma), increased intraocular pressure in hyperthyroidism, cardiovascular system, hypotension. Antihistamines drugs can reduce mental alertness as well as in adults and children and also cause agitation and hallucinations, convulsions and death in infants and children, especially in overdose. Precautions apply at age 60 and older because more likely to develop dizziness, sedation and hypotension. During treatment with Tesofan-J (Diphenhydramine) should avoid sun exposure. Should not be used during the drivers of vehicles and people, trade is connected with increased concentration. In the period of treatment should avoid drinking alcoholic beverages.

Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson drug interactions

When Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson applied simultaneously increases the effects of ethanol and drugs that depress the central nervous system.

With simultaneous use of Tesofan-J (Diphenhydramine) Xepa-Soul Pattinson and MAO inhibitors increase the anticholinergic activity of Tesofan-J (Diphenhydramine).

The antagonistic interaction observed with a joint appointment with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Intensifies anticholinergic effects of drugs with anticholinergic activity.

Tesofan-J Xepa-Soul Pattinson in case of emergency / overdose

Symptoms: dry mouth, difficulty breathing, persistent mydriasis, flushing, depression or excitement (more common in children), CNS confusion; children - the development of convulsions and death.

Treatment: induction of vomiting, gastric lavage, the prescription of activated charcoal, symptomatic and supportive therapy on a background of careful monitoring of respiration and blood pressure levels.