Termikit

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Termikit uses

Termikit consists of Azithromycin, Fluconazole, Ornidazole.

Azithromycin:


Pharmacological action

Termikit is a macrolide antibiotic of azalides group. Termikit (Azithromycin) inhibits RNA-dependent protein synthesis of sensitive microorganisms.

It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Pharmacokinetics

Termikit (Azithromycin) rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Termikit (Azithromycin). Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the Termikit (Azithromycin) is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.

Why is Termikit prescribed?

Infectious-inflammatory diseases caused by microorganisms susceptible to Termikit (Azithromycin), including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease (borreliosis).

Dosage and administration

Dosage of Termikit is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Termikit (Azithromycin) side effects, adverse reactions

Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.

Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Dermatological reactions: rarely - photosensitization.

CNS: dizziness, headache, rarely - drowsiness, weakness.

Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.

Cardiovascular system: rarely - chest pain.

Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.

Other: rarely - hyperglycemia, arthralgia.

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Contraindications

Hypersensitivity to Termikit and other macrolide antibiotics.

Using during pregnancy and breastfeeding

Termikit (Azithromycin) crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary to use Termikit (Azithromycin) in the lactation period should solve the issue of termination of breastfeeding.

Special instructions

Termikit not recommended for use in patients with compromised liver function.

Termikit (Azithromycin) uses with careful with impaired renal function.

This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.

Termikit (Azithromycin) drug interactions

Simultaneous administration of Termikit (Azithromycin) with these drugs and medications may has followed effects:

  • ergot alkaloids: can not been exclude the risk of ergotism;
  • warfarin: there was described amplification effect of warfarin;
  • digoxin or digitoxin: may be significantly increase the concentration of cardiac glycosides in plasma and risk of glycoside intoxication;
  • disopyramide: described a case of ventricular fibrillation;
  • lovastatin: there was describes some cases of rhabdomyolysis;
  • Termikit (Azithromycin) with rifabutin increases risk of neutropenia and leukopenia;
  • cyclosporine: disturbed metabolism of cyclosporine which increases the risk of adverse and toxic reactions caused by cyclosporine

  • Fluconazole:


    Pharmacological action

    Termikit is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.

    Pharmacokinetics

    Termikit (Fluconazole) is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Termikit (Fluconazole) is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Termikit (Fluconazole) is excreted by the kidneys, 80% of the administered dose in an unmodified form.

    Why is Termikit prescribed?

    Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.

    Dosage and administration

    Dosing regimen of Termikit is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Termikit (Fluconazole) should be reduced.

    Termikit (Fluconazole) side effects, adverse reactions

    Digestive system: nausea, abdominal pain, diarrhea, flatulence.

    CNS: headache, dizziness.

    Allergic reactions: skin rash, anaphylactic reactions.

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    Termikit contraindications

    Pregnancy, children up to age 1 year, increased sensitivity to Termikit (Fluconazole) and triazole compounds.

    Using during pregnancy and breastfeeding

    Termikit is contraindicated during pregnancy and lactation.

    If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

    Special instructions

    Termikit (Fluconazole) should be used with caution in patients with severe impaired liver or kidney diseases.

    Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.

    Termikit drug interactions

    Simultaneous administration of Termikit (Fluconazole) with:

  • coumarin anticoagulants marked increase in prothrombin time.
  • rifampicin observed shortening of the half-life of Termikit (Fluconazole). Termikit (Fluconazole) Sorres Pharma increases the half-life of oral hypoglycemic agents - sulfonylureas (chlorpropamide, glibenclamide, glipizide, tolbutamide) in healthy people. Simultaneous use of Termikit (Fluconazole) and oral hypoglycemic agents in diabetic patients is allowed, however, the physician should bear in mind the possibility of hypoglycemia.

    Termikit in case of emergency / overdose

    Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.

    Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.

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    Termikit pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Termikit available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Termikit destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Termikit Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Termikit pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."AZITHROMYCIN TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."FLUCONAZOLE TABLET [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."FLUCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Termikit?

    Depending on the reaction of the Termikit after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Termikit not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Termikit addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Termikit, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Termikit consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Termikit drug as prescribed by the doctor?

    Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Termikit is mentioned below.
    Visitors%
    Twice in a day1
    100.0%

    Visitor reported doses

    No survey data has been collected yet

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Visitor reported age

    No survey data has been collected yet

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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