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Simvastatin uses

Pharmacological action

Simvastatin is a hypolipidemic agent from a group of statins, an inhibitor of HMG-CoA reductase. This medication is a prodrug because it has in its structure the closed lactone ring which is hydrolyzed after intake.

Lipid-lowering effect of statins is associated with lower levels of total cholesterol by LDL-C. Reducing cholesterol is dose-dependent and is not linear but exponential. Statins do not affect the activity of lipoprotein and hepatic lipase, have no significant effect on the synthesis and catabolism of free fatty acids, thats why their effect on TG levels again and indirectly through their main effects on reducing LDL-C.

According to the controlled studies of Simvastatin increases HDL-C to 14%.

In addition to the hypolipidemic actions Simvastatin has beneficial effects in endothelial dysfunction, on the vascular wall, the state of atheroma, improves blood rheology, have antioxidant, antiproliferative properties. There is evidence that Simvastatin improves endothelial function within 30 days of therapy.

Simvastatin therapy was accompanied by a decrease in the incidence of cardiovascular disorders, regardless of baseline LDL-C.


After oral administration Simvastatin is well absorbed from the gastrointestinal tract (average 85%). Cmax is reached after 4 h. Taking Simvastatin just before eating with low fat does not affect its the pharmacokinetic parameters.

During a "first pass" through the liver Simvastatin biotransformed to form active beta-metabolites. The plasma protein binding is 95%.

The concentration of the active metabolite of Simvastatin in human systemic circulation is less than 5%.

Excreted in unchanged form and as metabolites, mainly in the bile - 60-85%, 10-15% - in the form of inactive metabolites are excreted by the kidneys.

Why is Simvastatin prescribed?

Primary hypercholesterolemia with the ineffectiveness of diets, combined hypercholesterolemia and hypertriglyceridemia.


Dosage and administration

The dosing regimen of Simvastatin is individual. The initial dose is 5-20 mg. If necessary the dose is increased every 4 weeks. Simvastatin is taken 1 time / day in the evening. The maximum dose is 40 mg / day.

For patients receiving immunosuppressive drugs, the recommended starting dose is 5 mg; the maximum dose is 5 mg / day.

In severe renal insufficiency, the initial dose is 5-10 mg / day.

Simvastatin side effects, adverse reactions

Digestive system: constipation, diarrhea, loss of appetite, flatulence, nausea, abdominal pain, pancreatitis, increased ALT, AST, GGT, ALP.

CNS and peripheral nervous system: headache, dizziness, muscle cramps, paresthesia, peripheral neuropathy.

Cardiovascular system: possible transient hypotension.

Musculoskeletal system: myalgia, myopathy, rhabdomyolysis, increased CPK.

Allergic reactions: seldom - angioedema, lupus like syndrome, vasculitis, thrombocytopenia, eosinophilia, ESR increase, arthritis, rash, fever, shortness of breath.

Dermatological reactions: photosensitivity, skin rash, itching, redness of skin, alopecia.

Other: anemia.

Simvastatin contraindications

An active pathological process in the liver, persistent elevation of transaminases, pregnancy, lactation, hypersensitivity to Simvastatin.

Using during pregnancy and breastfeeding

Simvastatin is contraindicated in pregnancy and lactation.

Category effects on the fetus by FDA - X.

Special instructions

With careful use Simvastatin in patients with liver disease, with chronic alcoholism, with hypotension, reduced or increased tone of skeletal muscle of unknown etiology, epilepsy, severe renal insufficiency.

Before and during treatment it is necessary to monitor liver function.

Patients receiving anticoagulant coumarin derivatives, before and during treatment with Simvastatin should monitor the prothrombin time.

Simvastatin therapy should be discontinued if a significant increase in CK activity or suspected myopathy, the development of acute or severe illness when any risk factors predisposing to renal failure due to rhabdomyolysis.

It is not recommended to use Simvastatin concurrently with immunosuppressants, fibrates, nicotinic acid, antifungal azole derivatives drugs.

Safety and efficacy of Simvastatin in a pediatric practice are not established. It is not recommended to use this medication for children.

Simvastatin drug interactions

Simultaneous administration of Simvastatin with:

  • amplified the effect of indirect anticoagulants (including warfarin).
  • digoxin increased digoxin concentration in blood plasma.
  • cytotoxic drugs, itraconazole, fibrates, nicotinic acid in high doses, immunosuppressants increases the risk of myopathy. There was described one case of symptoms of rhabdomyolysis after a single dose of sildenafil dose in patients receiving Simvastatin.


    Simvastatin pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

    Simvastatin available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

    Apo-Simvastatin 10 mg Tablet1.17 USD
    Apo-Simvastatin 20 mg Tablet1.45 USD
    Apo-Simvastatin 40 mg Tablet1.45 USD
    Apo-Simvastatin 5 mg Tablet0.59 USD
    Apo-Simvastatin 80 mg Tablet1.45 USD
    Capsules; Oral; Simvastatin 10 mg
    Co Simvastatin 10 mg Tablet1.17 USD
    Co Simvastatin 20 mg Tablet1.45 USD
    Co Simvastatin 40 mg Tablet1.45 USD
    Co Simvastatin 5 mg Tablet0.59 USD
    Co Simvastatin 80 mg Tablet1.45 USD
    Jamp-Simvastatin 10 mg Tablet1.17 USD
    Jamp-Simvastatin 20 mg Tablet1.45 USD
    Jamp-Simvastatin 40 mg Tablet1.45 USD
    Jamp-Simvastatin 5 mg Tablet0.59 USD
    Jamp-Simvastatin 80 mg Tablet1.45 USD
    Mylan-Simvastatin 10 mg Tablet1.17 USD
    Mylan-Simvastatin 20 mg Tablet1.45 USD
    Mylan-Simvastatin 40 mg Tablet1.45 USD
    Mylan-Simvastatin 5 mg Tablet0.59 USD
    Mylan-Simvastatin 80 mg Tablet1.45 USD
    Novo-Simvastatin 10 mg Tablet1.17 USD
    Novo-Simvastatin 20 mg Tablet1.45 USD
    Novo-Simvastatin 40 mg Tablet1.45 USD
    Novo-Simvastatin 5 mg Tablet0.59 USD
    Novo-Simvastatin 80 mg Tablet1.45 USD
    Phl-Simvastatin 10 mg Tablet1.17 USD
    Phl-Simvastatin 20 mg Tablet1.45 USD
    Phl-Simvastatin 40 mg Tablet1.45 USD
    Phl-Simvastatin 5 mg Tablet0.59 USD
    Phl-Simvastatin 80 mg Tablet1.45 USD
    Pms-Simvastatin 10 mg Tablet1.17 USD
    Pms-Simvastatin 20 mg Tablet1.45 USD
    Pms-Simvastatin 40 mg Tablet1.45 USD
    Pms-Simvastatin 5 mg Tablet0.59 USD
    Pms-Simvastatin 80 mg Tablet1.45 USD
    Ran-Simvastatin 10 mg Tablet1.17 USD
    Ran-Simvastatin 20 mg Tablet1.45 USD
    Ran-Simvastatin 40 mg Tablet1.45 USD
    Ran-Simvastatin 5 mg Tablet0.59 USD
    Ran-Simvastatin 80 mg Tablet1.45 USD
    Ratio-Simvastatin 10 mg Tablet1.17 USD
    Ratio-Simvastatin 20 mg Tablet1.45 USD
    Ratio-Simvastatin 40 mg Tablet1.45 USD
    Ratio-Simvastatin 80 mg Tablet1.45 USD
    Sandoz Simvastatin 10 mg Tablet1.17 USD
    Sandoz Simvastatin 20 mg Tablet1.45 USD
    Sandoz Simvastatin 40 mg Tablet1.45 USD
    Sandoz Simvastatin 80 mg Tablet1.45 USD
    Simvastatin 10 mg tablet2.31 USD
    Simvastatin 100% powder10.71 USD
    Simvastatin 20 mg tablet3.83 USD
    Simvastatin 40 mg tablet3.83 USD
    Simvastatin 5 mg tablet1.63 USD
    Simvastatin 80 mg tablet3.83 USD
    Tablets, Film-Coated; Oral; Simvastatin 10 mg
    Tablets, Film-Coated; Oral; Simvastatin 20 mg
    Tablets, Film-Coated; Oral; Simvastatin 30 mg
    Tablets, Film-Coated; Oral; Simvastatin 40 mg
    Tablets, Film-Coated; Oral; Simvastatin 5 mg
    Tablets, Film-Coated; Oral; Simvastatin 60 mg
    Tablets, Film-Coated; Oral; Simvastatin 80 mg
    Tablets, Orally Disintegrating; Oral; Simvastatin 10 mg
    Tablets, Orally Disintegrating; Oral; Simvastatin 20 mg
    Tablets, Orally Disintegrating; Oral; Simvastatin 40 mg
    Tablets, Orally Disintegrating; Oral; Simvastatin 80 mg
    Tablets; Oral; Simvastatin 10 mg
    Tablets; Oral; Simvastatin 20 mg
    Tablets; Oral; Simvastatin 40 mg
    Tablets; Oral; Simvastatin 5 mg
    Tablets; Oral; Simvastatin 80 mg
    Vytorin 10-10 mg tablet4.97 USD
    Vytorin 10-20 mg tablet5.05 USD
    Vytorin 10-40 mg tablet5.05 USD
    Vytorin 10-80 mg tablet4.63 USD
    Zocor 10 mg tablet2.89 USD
    Zocor 20 mg tablet4.69 USD
    Zocor 40 mg tablet4.11 USD
    Zocor 5 mg tablet1.99 USD
    Zocor 80 mg tablet4.69 USD
    Zocor 90 40 mg tablet Bottle525.16 USD


    Simvastatin destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

    Simvastatin Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

    Simvastatin pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



    1. Dailymed."ZOCOR (SIMVASTATIN) TABLET, FILM COATED [MERCK SHARP & DOHME CORP.]". (accessed August 28, 2018).
    2. Dailymed."SIMVASTATIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed August 28, 2018).
    3. "simvastatin". (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Simvastatin?

    Depending on the reaction of the Simvastatin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Simvastatin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Simvastatin addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


    Review conducted a study on Simvastatin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Simvastatin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug Simvastatin useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Not useful1

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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