Selenium, Beta-Carotene Vitamin C and E

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Selenium, Beta-Carotene Vitamin C and E uses

Selenium, Beta-Carotene Vitamin C and E consists of Beta-Carotene, Selenium (Selenium Proteinate), Vitamin C (Ascorbic Acid), Vitamin E (D-Alpha Tocopherol Acetate).

Selenium (Selenium Proteinate):



Rx Only

TRACE ELEMENT ADDITIVE FOR IV USE AFTER DILUTION

DESCRIPTION

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection is a sterile, nonpyrogenic solution for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Each mL contains Selenious Acid 65.4 mcg (equivalent to elemental Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) 40 mcg/mL) and Water for Injection q.s. pH may be adjusted with nitric acid to 1.8 to 2.4.

CLINICAL PHARMACOLOGY

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) is part of glutathione peroxidase which protects cell components from oxidative damage due to peroxides produced in cellular metabolism.

Prolonged TPN support in humans has resulted in Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) deficiency symptoms which include muscle pain and tenderness. The symptoms have been reported to respond to supplementation of TPN solutions with Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)).

Pediatric conditions, Keshan disease, and Kwashiorkor, have been associated with low dietary intake of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)). The conditions are endemic to geographical areas with low Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) soil content. Dietary supplementation with Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) salts has been reported to reduce the incidence of the conditions among affected children.

Normal blood levels of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) in different human populations have been found to vary and depend on the Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) content of the food consumed. Results of surveys carried out in some countries are tabulated below:



COUNTRY


Number of

Samples

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) (mcg/100 mL) (a)

Whole Blood


Blood Cells

Plasma/

Serum

(a) Mean values with or without standard deviation in parentheses, all other ranges.
(b) Age group unknown.
(c) Three children recovered from Kwashiorkor and the other six under treatment for other diseases.
(d) Low selenium-content soil area.
(e) Well nourished children, three recovered from Kwashiorkor and the other six under treatment for other diseases.
(f) Mean values from seven subjects.
Canada 254 Adults (37.9 ± 7.8) (23.6 ± 6.0) (14.4 ± 2.9)
England 8 (b) 26-37 (32) -- --
Guatemala &

Southern USA

10 Adults

9 Children (c)

19-28 (22)

(23 ± 5)

--

(36 ± 12)

--

(15 ± 5)

New Zealand (d) 113 Adults (5.4 ± 0.1) (6.6 ± 0.3) (4.3 ± 0.1)
Thailand 3 Adults

9 Children (e)

14.4-20.2

(12.0 ± 3.6) (f)

17.8-35.8

(19.5 ± 8.2)

8.1-12.5

(8.3 ± 2.2)

USA 210 Adults 15.7-25.6

(20.6)

-- --

Plasma Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) levels of 0.3 and 0.9 mcg/100 mL have been reported to produce deficiency symptoms in humans.

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) is eliminated primarily in urine. However, significant endogenous losses through feces also occur. The rate of excretion and the relative importance of two routes varies with the chemical form of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) used in supplementation. Ancillary routes of elimination are lungs and skin.

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INDICATIONS AND USAGE

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) in TPN solutions helps to maintain plasma Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

CONTRAINDICATIONS

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

WARNINGS

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection can be toxic if given in excessive amounts. Supplementation of TPN solution with Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) should be immediately discontinued if toxicity symptoms are observed. Frequent determination of plasma Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) levels during TPN support and close medical supervision is recommended.

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection is a hypotonic solution and should be administered in admixtures only.

This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

PRECAUTIONS

As Selenium, Beta-Carotene Vitamin C and E ) is eliminated in urine and feces, Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) supplements may be adjusted, reduced or omitted in renal dysfunction and/or gastrointestinal malfunction. In patients receiving blood transfusions, contribution from such transfusions should also be considered. Frequent Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) plasma level determinations are suggested as a guideline.

In animals, Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) has been reported to enhance the action of Vitamin E and decrease the toxicity of mercury, cadmium and arsenic.

Pregnancy

Teratogenic Effects

Pregnancy Category C: Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) at high dose levels (15-30 mcg/egg) has been reported to have adverse embryological effects among chickens. There are however, no adequate and wellcontrolled studies in pregnant women. Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection should be used during pregnancy only if potential benefit justifies the potential risk to the fetus.

Presence of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) in placenta and umbilical cord blood has been reported in humans.

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ADVERSE REACTIONS

The amount of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) present in Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection is small. Symptoms of toxicity from Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) are unlikely to occur at the recommended dosage level.

OVERDOSAGE

Chronic toxicity in humans resulting from exposure to Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) in industrial environments, intake of foods grown in seleniferous soils, use of selenium-contaminated water, and application of cosmetics containing Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) has been reported in literature. Toxicity symptoms include hair loss, weakened nails, dermatitis, dental defects, gastrointestinal disorders, nervousness, mental depression, metallic taste, vomiting, and garlic odor of breath and sweat. Acute poisoning due to ingestion of large amounts of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) compounds has resulted in death with histopathological changes including fulminating peripheral vascular collapse, internal vascular congestion, diffusely hemorrhagic, congested and edematus lungs, brick-red color gastric mucosa. The death was preceded by coma.

No effective antidote to Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) poisoning in humans is known. Animal studies have shown casein and linseed oil in feeds, reduced glutathione, arsenic, magnesium sulfate, and bromobenzene to afford limited protection.

DOSAGE AND ADMINISTRATION

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection provides 40 mcg selenium/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg selenium/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.

In adults, Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) deficiency states resulting from long-term TPN support, Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.

Aseptic addition of Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection to the TPN solution under laminar flow hood is recommended. Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) is approximately 10 to 37 mcg/100 mL.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

HOW SUPPLIED

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) Injection containing selenious acid 65.4 mcg/mL (equivalent to elemental Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) 40 mcg/mL).

NDC 0517-6510-25 10 mL Single Dose Vial Packaged in boxes of 25

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F).

AMERICAN

REGENT, INC.

SHIRLEY, NY 11967

IN6510

Rev. 11/15

PRINCIPAL DISPLAY PANEL - Container

NDC 0517-6510-25

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) INJECTION

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) 400 mcg/10 mL

(40 mcg/mL)

10 mL

SINGLE DOSE VIAL

Trace Element Additive

FOR IV USE AFTER DILUTION

PRESERVATIVE FREE

Rx Only

AMERICAN REGENT, INC.

SHIRLEY, NY 11967

PRINCIPAL DISPLAY PANEL - Carton

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) INJECTION

Selenium, Beta-Carotene Vitamin C and E (Selenium (Selenium Proteinate)) 400 mcg/10 mL

(40 mcg/mL)

Trace Element Additive

NDC 0517-6510-25

25 x 10 mL

SINGLE DOSE VIALS

FOR INTRAVENOUS USE AFTER DILUTION PRESERVATIVE FREE Rx Only

Each mL contains: Selenious Acid 65.4 mcg, Water for Injection q.s.

pH adjusted with Nitric Acid. Sterile, nonpyrogenic.

WARNING: DISCARD UNUSED PORTION. Store at 20°-25°C (68°-77°F); excursions

permitted to 15°-30°C (59°-86°F).

Directions for Use: See Package Insert.

AMERICAN REGENT, INC.

SHIRLEY, NY 11967

Rev. 11/05

Container Carton

Vitamin C (Ascorbic Acid):


Pharmacological action

Selenium, Beta-Carotene Vitamin C and E ) (vitamin c) is essential for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones, and the capillary walls. Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) participates in redox reactions, the metabolism of tyrosine, converting folic acid into folinic acid, metabolism of carbohydrates, the synthesis of lipids and proteins, iron metabolism, processes of cellular respiration. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, enhances the body's resistance to infections; enhances iron absorption, contributing to its sequestration in reduced form. Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) has antioxidant properties.

With intravaginal application of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) lowers the vaginal pH, inhibiting the growth of bacteria and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).

Pharmacokinetics

After oral administration Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) is completely absorbed from the gastrointestinal tract. Widely distributed in body tissues.

The concentration of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in blood plasma in normal amounts to approximately 10-20 mg / ml.

The concentration of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in white blood cells and platelets is higher than in erythrocytes and plasma. When deficient state of concentration in leucocytes is reduced later and more slowly and is regarded as the best criterion for evaluating the deficit than the concentration in plasma.

Plasma protein binding is about 25%.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) is reversibly oxidized to form dehydroascorbic acid, is metabolized with the formation of ascorbate-2-sulphate which is inactive and oxalic acid which is excreted in the urine.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) taken in excessive quantities is rapidly excreted unchanged in urine, it usually happens when exceeding a daily dose is 200 mg.

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Why is Selenium, Beta-Carotene Vitamin C and E ) prescribed?

For systemic use of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) RiteMED Phils: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Dosage and administration

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions Selenium, Beta-Carotene Vitamin C and E ) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) drugs in appropriate dosage forms.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) side effects, adverse reactions

CNS: headache, fatigue, insomnia.

Digestive system: stomach cramps, nausea and vomiting.

Allergic reaction: describes a few cases of skin reactions and manifestations of the respiratory system.

Urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones of calcium oxalate.

Local reactions: with intravaginal application - a burning or itching in the vagina, increased mucous discharge, redness, swelling of the vulva. Other: sensation of heat.

Selenium, Beta-Carotene Vitamin C and E ) contraindications

Increased sensitivity to Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)).

Using during pregnancy and breastfeeding

The minimum daily requirement of Selenium, Beta-Carotene Vitamin C and E ) in the II and III trimester of pregnancy is about 60 mg.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) crosses the placental barrier. It should be borne in mind that the fetus can adapt to high doses of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)), which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. Therefore, during pregnancy should not to take Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in high doses, except in cases where the expected benefit outweighs the potential risk.

The minimum daily requirement during lactation (breastfeeding) is 80 mg. Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) is excreted in breast milk. A mother's diet that contains adequate amounts of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)), is sufficient to prevent deficiency in an infant. It is unknown whether dangerous to the child's mother use of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in high doses. Theoretically it is possible. Therefore, it is recommended not to exceed the maximum daily nursing mother needs to Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)), except when the expected benefit outweighs the potential risk.

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Special instructions

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia.

Patients with high content body iron should apply Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in minimal doses.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase.

The use of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in high doses can cause exacerbation of sickle cell anemia.

Data on the diabetogenic action of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) are contradictory. However, prolonged use of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) should periodically monitor your blood glucose levels.

It is believed that the use of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in patients with advanced cancer.

Absorption of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) decreased while use of fresh fruit or vegetable juices, alkaline drinking.

Selenium, Beta-Carotene Vitamin C and E ) drug interactions

In an application with barbiturates, primidone increases the excretion of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in blood plasma.

In an application of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) with iron preparations Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) by about a third.

Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) increases the excretion of iron in patients receiving deferoxamine. In the application of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Selenium, Beta-Carotene Vitamin C and E (Vitamin C (Ascorbic Acid)) 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

Selenium, Beta-Carotene Vitamin C and E ) in case of emergency / overdose

Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day).

Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy).

When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.

Vitamin E (D-Alpha Tocopherol Acetate):


A generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids.

Indication: Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)), known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.

Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) has antioxidant activity. It may also have anti-atherogenic, antithrombotic, anticoagulant, neuroprotective, antiviral, immunomodulatory, cell membrane-stabilizing and antiproliferative actions. Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) is a collective term used to describe eight separate forms, the best-known form being alpha-tocopherol. Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) is a fat-soluble vitamin and is an important antioxidant. It acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body's metabolism. Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) is often used in skin creams and lotions because it is believed to play a role in encouraging skin healing and reducing scarring after injuries such as burns. There are three specific situations when a Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) deficiency is likely to occur. It is seen in persons who cannot absorb dietary fat, has been found in premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), and is seen in individuals with rare disorders of fat metabolism. A Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) deficiency is usually characterized by neurological problems due to poor nerve conduction. Symptoms may include infertility, neuromuscular impairment, menstrual problems, miscarriage and uterine degradation. Preliminary research has led to a widely held belief that Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) may help prevent or delay coronary heart disease. Antioxidants such as Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) help protect against the damaging effects of free radicals, which may contribute to the development of chronic diseases such as cancer. It also protects other fat-soluble vitamins (A and B group vitamins) from destruction by oxygen. Low levels of Selenium, Beta-Carotene Vitamin C and E (Vitamin E (D-Alpha Tocopherol Acetate)) have been linked to increased incidence of breast and colon cancer.

Selenium, Beta-Carotene Vitamin C and E pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Selenium, Beta-Carotene Vitamin C and E available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Selenium, Beta-Carotene Vitamin C and E destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Selenium, Beta-Carotene Vitamin C and E Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Selenium, Beta-Carotene Vitamin C and E pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."BETA CAROTENE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. "beta-carotene". https://pubchem.ncbi.nlm.nih.gov/su... (accessed August 28, 2018).
  3. "Selenium". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Selenium, Beta-Carotene Vitamin C and E?

Depending on the reaction of the Selenium, Beta-Carotene Vitamin C and E after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Selenium, Beta-Carotene Vitamin C and E not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Selenium, Beta-Carotene Vitamin C and E addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Selenium, Beta-Carotene Vitamin C and E, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Selenium, Beta-Carotene Vitamin C and E consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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