Scheeling CeeZinc Vit C Plus Zinc for Kids

Vitamin C (Ascorbic Acid):

• Pharmacological action
• Pharmacokinetics
• Why is Scheeling CeeZinc Vit C Plus Zinc for Kids ) prescribed?
• Dosage and administration
• Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) side effects, adverse reactions
• Scheeling CeeZinc Vit C Plus Zinc for Kids ) contraindications
• Using during pregnancy and breastfeeding
• Special instructions
• Scheeling CeeZinc Vit C Plus Zinc for Kids ) drug interactions
• Scheeling CeeZinc Vit C Plus Zinc for Kids ) in case of emergency / overdose
• Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) reviews

Pharmacological action

Scheeling CeeZinc Vit C Plus Zinc for Kids ) (vitamin c) is essential for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones, and the capillary walls. Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) participates in redox reactions, the metabolism of tyrosine, converting folic acid into folinic acid, metabolism of carbohydrates, the synthesis of lipids and proteins, iron metabolism, processes of cellular respiration. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, enhances the body's resistance to infections; enhances iron absorption, contributing to its sequestration in reduced form. Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) has antioxidant properties.

With intravaginal application of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) lowers the vaginal pH, inhibiting the growth of bacteria and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri).

Pharmacokinetics

After oral administration Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) is completely absorbed from the gastrointestinal tract. Widely distributed in body tissues.

The concentration of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in blood plasma in normal amounts to approximately 10-20 mg / ml.

The concentration of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in white blood cells and platelets is higher than in erythrocytes and plasma. When deficient state of concentration in leucocytes is reduced later and more slowly and is regarded as the best criterion for evaluating the deficit than the concentration in plasma.

Plasma protein binding is about 25%.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) is reversibly oxidized to form dehydroascorbic acid, is metabolized with the formation of ascorbate-2-sulphate which is inactive and oxalic acid which is excreted in the urine.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) taken in excessive quantities is rapidly excreted unchanged in urine, it usually happens when exceeding a daily dose is 200 mg.

Why is Scheeling CeeZinc Vit C Plus Zinc for Kids ) prescribed?

For systemic use of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) RiteMED Phils: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Dosage and administration

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions Scheeling CeeZinc Vit C Plus Zinc for Kids ) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) drugs in appropriate dosage forms.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) side effects, adverse reactions

CNS: headache, fatigue, insomnia.

Digestive system: stomach cramps, nausea and vomiting.

Allergic reaction: describes a few cases of skin reactions and manifestations of the respiratory system.

Urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones of calcium oxalate.

Local reactions: with intravaginal application - a burning or itching in the vagina, increased mucous discharge, redness, swelling of the vulva. Other: sensation of heat.

Scheeling CeeZinc Vit C Plus Zinc for Kids ) contraindications

Increased sensitivity to Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)).

Using during pregnancy and breastfeeding

The minimum daily requirement of Scheeling CeeZinc Vit C Plus Zinc for Kids ) in the II and III trimester of pregnancy is about 60 mg.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) crosses the placental barrier. It should be borne in mind that the fetus can adapt to high doses of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)), which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. Therefore, during pregnancy should not to take Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in high doses, except in cases where the expected benefit outweighs the potential risk.

The minimum daily requirement during lactation (breastfeeding) is 80 mg. Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) is excreted in breast milk. A mother's diet that contains adequate amounts of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)), is sufficient to prevent deficiency in an infant. It is unknown whether dangerous to the child's mother use of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in high doses. Theoretically it is possible. Therefore, it is recommended not to exceed the maximum daily nursing mother needs to Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)), except when the expected benefit outweighs the potential risk.

Special instructions

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia.

Patients with high content body iron should apply Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in minimal doses.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase.

The use of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in high doses can cause exacerbation of sickle cell anemia.

Data on the diabetogenic action of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) are contradictory. However, prolonged use of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) should periodically monitor your blood glucose levels.

It is believed that the use of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in patients with advanced cancer.

Absorption of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) decreased while use of fresh fruit or vegetable juices, alkaline drinking.

Scheeling CeeZinc Vit C Plus Zinc for Kids ) drug interactions

In an application with barbiturates, primidone increases the excretion of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in blood plasma.

In an application of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) with iron preparations Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) by about a third.

Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) increases the excretion of iron in patients receiving deferoxamine. In the application of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Scheeling CeeZinc Vit C Plus Zinc for Kids (Vitamin C (Ascorbic Acid)) 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

Scheeling CeeZinc Vit C Plus Zinc for Kids ) in case of emergency / overdose

Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day).

Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy).

When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.

Zinc:

• Indications and usage
• Contraindications
• Warnings
• Precautions
• Adverse reactions
• Drug abuse and dependence
• Overdosage
• Dosage and administration
• How supplied
• Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) reviews

INDICATIONS AND USAGE

Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) 1 mg/mL (Zinc Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for TPN. Administration helps to maintain Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) serum levels and to prevent depletion of endogenous stores, and subsequent deficiency symptoms.

CONTRAINDICATIONS

None known.

WARNINGS

Direct intramuscular or intravenous injection of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) 1 mg/mL (Zinc Chloride Injection, USP) is contraindicated as the acidic pH of the solution (2) may cause considerable tissue irritation.

Severe kidney disease may make it necessary to reduce or omit chromium and Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) doses because these elements are primarily eliminated in the urine.

WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

PRECAUTIONS

General

Do not use unless the solution is clear and the seal is intact.

Zinc 1 mg/mL should only be used in conjunction with a pharmacy directed admixture program using aseptic technique in a laminar flow environment; it should be used promptly and in a single operation without any repeated penetrations. Solution contains no preservatives; discard unused portion immediately after admixture procedure is completed.

Zinc should not be given undiluted by direct injection into a peripheral vein because of the likelihood of infusion phlebitis and the potential for increased excretory loss of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) from a bolus injection. Administration of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) in the absence of copper may cause a decrease in serum copper levels.

Laboratory Tests

Periodic determinations of serum copper as well as Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) are suggested as a guideline for subsequent Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) administration.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term animal studies to evaluate the carcinogenic potential of Scheeling CeeZinc Vit C Plus Zinc for Kids 1 mg/mL (Zinc Chloride Injection, USP) have not been performed, nor have studies been done to assess mutagenesis or impairment of fertility.

Nursing Mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) 1 mg/mL (Zinc Chloride Injection, USP) is administered to a nursing woman.

Pediatric Use

Pregnancy Category C. Animal reproduction studies have not been conducted with Scheeling CeeZinc Vit C Plus Zinc for Kids chloride. It is also not known whether Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) chloride should be given to a pregnant woman only if clearly needed.

Geriatric Use

An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

ADVERSE REACTIONS

None known.

DRUG ABUSE AND DEPENDENCE

None known.

OVERDOSAGE

Single intravenous doses of 1 to 2 mg zinc/kg body weight have been given to adult leukemic patients without toxic manifestations. However, acute toxicity was reported in an adult when 10 mg Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) was infused over a period of one hour on each of four consecutive days. Profuse sweating, decreased level of consciousness, blurred vision, tachycardia (140/min), and marked hypothermia (94.2° F) on the fourth day were accompanied by a serum Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) concentration of 207 mcg/dl. Symptoms abated within three hours.

Hyperamylasemia may be a sign of impending Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) overdosage; patients receiving an inadvertent overdose (25 mg zinc/liter of TPN solution, equivalent to 50 to 70 mg zinc/day) developed hyperamylasemia (557 to 1850 Klein units; normal: 130 to 310).

Death resulted from an overdosage in which 1683 mg Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) was delivered intravenously over the course of 60 hours to a 72 year old patient.

Symptoms of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) toxicity included hypotension (80/40 mm Hg), pulmonary edema, diarrhea, vomiting, jaundice, and oliguria, with a serum Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) level of 4184 mcg/dl.

Calcium supplements may confer a protective effect against Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) toxicity.

DOSAGE AND ADMINISTRATION

Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) 1 mg/mL (Zinc Chloride Injection, USP) contains 1 mg zinc/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg zinc/day (2.5 to 4 mL/day). An additional 2 mg zinc/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg zinc/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg zinc/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc).

For full term infants and children up to 5 years of age, 100 mcg zinc/kg/day (0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg zinc/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

HOW SUPPLIED

Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) 1 mg/mL (Zinc Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

Revised: October, 2004

© Hospira 2004 EN-0488 Printed in USA

HOSPIRA, INC., LAKE FOREST, IL 60045 USA

10 mL Vial

Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc)

1 mg/mL

Scheeling CeeZinc Vit C Plus Zinc for Kids (Zinc) Chloride Inj., USP

Rx only

FOR I.V. USE ONLY AFTER DILUTION.

HOSPIRA, INC., LAKE FOREST, IL 60045 USA