Rosel-T

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Rosel-T uses

Rosel-T consists of Acetaminophen, Amantadine Hydrochloride, Chlorpheniramine Maleate.

Acetaminophen:


Pharmacological action

Rosel-T is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Rosel-T (Acetaminophen) prescribed?

Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.

Rosel-T dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Rosel-T side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Rosel-T, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).

Using during pregnancy and breastfeeding

Rosel-T (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Rosel-T (Acetaminophen) on the fetus in humans.

Rosel-T (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Rosel-T (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Rosel-T (Acetaminophen).

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Special Instructions

Rosel-T is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Rosel-T (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).

Rosel-T (Acetaminophen) Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Rosel-T (Acetaminophen).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Rosel-T (Acetaminophen).

With the simultaneous use of oral contraceptives accelerated excretion of Rosel-T (Acetaminophen) from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Rosel-T (Acetaminophen).

When Rosel-T (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Rosel-T (Acetaminophen). A case of severe toxic liver injury.

Described cases of toxic effects of Rosel-T (Acetaminophen), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Rosel-T (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Rosel-T (Acetaminophen) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Rosel-T (Acetaminophen) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Rosel-T (Acetaminophen) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Rosel-T (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Rosel-T (Acetaminophen) due to increasing its metabolism in the liver.

At simultaneous application of Rosel-T (Acetaminophen) with ethinylestradiol increases absorption of Rosel-T (Acetaminophen) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Rosel-T in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

Amantadine Hydrochloride:


Pharmacological action

Rosel-T is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.

This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. Rosel-T (Amantadine Hydrochloride) inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater Rosel-T (Amantadine Hydrochloride) influences on stiffness (rigidity and bradykinesia).

This medicine inhibits the penetration of influenza A virus into the cell.

Pharmacokinetics

Rosel-T (Amantadine Hydrochloride) after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of Rosel-T (Amantadine Hydrochloride) sulfate is 12-13 hours, in contrast to Rosel-T (Amantadine Hydrochloride) hydrochloride, which T1/2 is 30 hours.

Why is Rosel-T prescribed?

Parkinson's disease, Parkinson's syndrome (rigidity, tremor, hypokinesia).

Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.

Prevention (including in combination with vaccination) and treatment of influenza A.

Dosage and administration

For oral administration the single dose is 100-200 mg.

IV in the form of infusion in 200 mg during 3 hours.

The frequency and duration of Rosel-T use depends on the evidence, the patient's response to treatment, the epidemiological situation.

The maximum dose for oral administration is 600 mg / day.

Rosel-T (Amantadine Hydrochloride) side effects, adverse reactions

CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.

Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.

Digestive system: rarely - anorexia, nausea, constipation, dry mouth.

Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.

Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities (livedo reticularis).

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Rosel-T contraindications

Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to Rosel-T (Amantadine Hydrochloride).

Using during pregnancy and breastfeeding

The use of Rosel-T in pregnancy is possible only under strict indications and under the supervision of a physician.

If necessary to use during lactation it been should decide on the termination of breastfeeding.

Category of the fetus by FDA - C.

Special instructions

Use Rosel-T (Amantadine Hydrochloride) with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of Rosel-T (Amantadine Hydrochloride) is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.

An information about the effectiveness of Rosel-T (Amantadine Hydrochloride) to reduce extrapyramidal disorders during treatment with antipsychotic drugs (Parkinson's drug) are contradictory.

During treatment avoid drinking alcohol.

In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.

Rosel-T drug interactions

When this drug applied simultaneously with:

- may increase the side effects of other antiparkinsonian medications.

- thiazide diuretics can not been excluded the possibility of toxic effects of Rosel-T (Amantadine Hydrochloride) (ataxia, agitation, hallucinations), probably by reducing its renal clearance.

- quinine, quinidine may decrease the excretion of Rosel-T (Amantadine Hydrochloride) in urine.

There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.

Chlorpheniramine Maleate:



Drug Facts

Active Ingredients (in each 1 mL dropperful) Purpose
Rosel-T (Chlorpheniramine Maleate) Maleate 2 mg Antihistamine
Phenylephrine HCl 5 mg Nasal Decongestant

Uses

temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies

  • runny nose
  • sneezing
  • itching of the nose or throat
  • itchy, watery eyes
  • nasal congestion
  • reduces swelling of nasal passages

Warnings

Do not exceed recommended dosage.

Do not use this product in a child who is

  • now taking a prescription monoamine oxidase inhibitor (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product.

Ask a doctor before use if a child has

  • a breathing problem such as chronic bronchitis
  • glaucoma
  • heart disease
  • high blood pressure
  • thyroid disease
  • diabetes mellitus

Ask a doctor before use if a child is taking sedatives or tranquilizers

When using this product

  • excitability may occur, especially in children
  • may cause drowsiness
  • sedatives and tranquilizers may increase drowsiness effect

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur
  • new symptoms occur

Keep out of reach of children. In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.

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Directions

Do not exceed recommended dosage.

Children 6 to under 12 years of age: 1 mL (1 dropperful) every 4 hours, not to exceed 6 mL in 24 hours or as directed by a doctor
Children 2 to under 6 years of age: 0.5 mL (1/2 dropperful) every 4 hours, not to exceed 3 mL in 24 hours, or as directed by a doctor
Children under 2 years of age: Consult a doctor

Other information

Store at 59°-86°F (15°-30°C)

Inactive ingredients

Applesauce Flavor, Citric Acid, FD&C Blue #1, FD&C Yellow #6, Glycerin, Methyl Paraben, Potassium Citrate, Potassium Sorbate, Propyl Paraben, Propylene Glycol, Purified Water, Sucralose

Questions? Comments?

Call 1-800-543-9560

Rev. 05/11

E

NEW

FORMULA

NDC 00485-0096-02

Rosel-T (Chlorpheniramine Maleate)

Pediatric Drops

Antihistamine ▪ Nasal Decongestant

Sugar Free ▪ Alcohol Free ▪ Gluten Free

FOR PROFESSIONAL USE ONLY

Each 1 mL for oral administration

contains:

Rosel-T (Chlorpheniramine Maleate) Maleate

2 mg

Phenylephrine HCl

5 mg

APPLESAUCE FLAVOR

Tamper evident by foil seal under cap.

Do not use if foil seal is broken or missing.

Manufactured for:

EDWARDS

Pharmaceuticals, Inc.

Ripley, MS 38663

2 fl. oz. (60 mL)

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Rosel-T pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Rosel-T available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Rosel-T destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Rosel-T Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Rosel-T pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."AMANTADINE HYDROCHLORIDE TABLET [ACTAVIS PHARMA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. Dailymed."WAL-FINATE (CHLORPHENIRAMINE MALEATE) TABLET [WALGREEN COMPANY]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Rosel-T?

Depending on the reaction of the Rosel-T after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Rosel-T not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Rosel-T addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Rosel-T, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Rosel-T consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Rosel-T useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Not useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Rosel-T is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Not expensive1
100.0%

Visitor reported frequency of use

No survey data has been collected yet

Six visitors reported doses

What is the dose of Rosel-T drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
11-50mg3
50.0%
51-100mg2
33.3%
201-500mg1
16.7%

Two visitors reported time for results

What is the time duration Rosel-T drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 2 days to notice the result from using Rosel-T drug. The time needed to show improvement in health condition after using the medicine Rosel-T need not be same for all the users. It varies based on other factors.
Visitors%
2 days1
50.0%
1 day1
50.0%

One visitor reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Rosel-T drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
After food1
100.0%

Fifteen visitors reported age

Visitors%
16-294
26.7%
30-454
26.7%
> 603
20.0%
46-603
20.0%
6-151
6.7%

Visitor reviews


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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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