DRUGS & SUPPLEMENTS
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Rosel is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.
Pain weak and moderate intensity of different genesis (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in trauma, burns). Fever in infectious and inflammatory diseases.
Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.
Maximum dose: single - 1 g, daily - 4 g.
Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.
Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.
Maximum dose: 4 single dose per day.
Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.
Chronic active alcoholism, increased sensitivity to Rosel, marked disturbances of liver function and / or kidney disease, anemia, pregnancy (I term).
Rosel (Acetaminophen) crosses the placental barrier. So far, no observed adverse effects of Rosel (Acetaminophen) on the fetus in humans.
Rosel (Acetaminophen) is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.
If necessary, use of Rosel (Acetaminophen) during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.
In experimental studies found no embryotoxic, teratogenic and mutagenic action of Rosel (Acetaminophen).
Rosel is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.
With prolonged use of Rosel (Acetaminophen) is necessary to monitor patterns of peripheral blood and functional state of the liver.
Used for treatment of premenstrual tension syndrome in combination with pamabrom (diuretic, a derivative of xanthine) and mepyramine (Histamine H1-receptors blocker).
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Rosel (Acetaminophen).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Rosel (Acetaminophen).
With the simultaneous use of oral contraceptives accelerated excretion of Rosel (Acetaminophen) from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Rosel (Acetaminophen).
When Rosel (Acetaminophen) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Rosel (Acetaminophen). A case of severe toxic liver injury.
Described cases of toxic effects of Rosel (Acetaminophen), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Rosel (Acetaminophen), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Rosel (Acetaminophen) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Rosel (Acetaminophen) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Rosel (Acetaminophen) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Rosel (Acetaminophen), with rifampicin, sulfinpyrazone - may increase clearance of Rosel (Acetaminophen) due to increasing its metabolism in the liver.
At simultaneous application of Rosel (Acetaminophen) with ethinylestradiol increases absorption of Rosel (Acetaminophen) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.
Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms
Rosel is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.
This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. Rosel (Amantadine) inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater Rosel (Amantadine) influences on stiffness (rigidity and bradykinesia).
This medicine inhibits the penetration of influenza A virus into the cell.
Rosel (Amantadine) after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of Rosel (Amantadine) sulfate is 12-13 hours, in contrast to Rosel (Amantadine) hydrochloride, which T1/2 is 30 hours.
Parkinson's disease, Parkinson's syndrome (rigidity, tremor, hypokinesia).
Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.
Prevention (including in combination with vaccination) and treatment of influenza A.
For oral administration the single dose is 100-200 mg.
IV in the form of infusion in 200 mg during 3 hours.
The frequency and duration of Rosel use depends on the evidence, the patient's response to treatment, the epidemiological situation.
The maximum dose for oral administration is 600 mg / day.
CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.
Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.
Digestive system: rarely - anorexia, nausea, constipation, dry mouth.
Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.
Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities (livedo reticularis).
Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to Rosel (Amantadine).
The use of Rosel in pregnancy is possible only under strict indications and under the supervision of a physician.
If necessary to use during lactation it been should decide on the termination of breastfeeding.
Category of the fetus by FDA - C.
Use Rosel (Amantadine) with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of Rosel (Amantadine) is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.
An information about the effectiveness of Rosel (Amantadine) to reduce extrapyramidal disorders during treatment with antipsychotic drugs (Parkinson's drug) are contradictory.
During treatment avoid drinking alcohol.
In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.
When this drug applied simultaneously with:
- may increase the side effects of other antiparkinsonian medications.
- thiazide diuretics can not been excluded the possibility of toxic effects of Rosel (Amantadine) (ataxia, agitation, hallucinations), probably by reducing its renal clearance.
- quinine, quinidine may decrease the excretion of Rosel (Amantadine) in urine.
There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.
|Active Ingredients (in each 1 mL dropperful)||Purpose|
|Rosel (Chlorpheniramine) Maleate 2 mg||Antihistamine|
|Phenylephrine HCl 5 mg||Nasal Decongestant|
temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies
Do not exceed recommended dosage.
Ask a doctor before use if a child is taking sedatives or tranquilizers
Keep out of reach of children. In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.
Do not exceed recommended dosage.
|Children 6 to under 12 years of age:||1 mL (1 dropperful) every 4 hours, not to exceed 6 mL in 24 hours or as directed by a doctor|
|Children 2 to under 6 years of age:||0.5 mL (1/2 dropperful) every 4 hours, not to exceed 3 mL in 24 hours, or as directed by a doctor|
|Children under 2 years of age:||Consult a doctor|
Store at 59°-86°F (15°-30°C)
Applesauce Flavor, Citric Acid, FD&C Blue #1, FD&C Yellow #6, Glycerin, Methyl Paraben, Potassium Citrate, Potassium Sorbate, Propyl Paraben, Propylene Glycol, Purified Water, Sucralose
Antihistamine ▪ Nasal Decongestant
Sugar Free ▪ Alcohol Free ▪ Gluten Free
FOR PROFESSIONAL USE ONLY
Each 1 mL for oral administration
Rosel (Chlorpheniramine) Maleate
Tamper evident by foil seal under cap.
Do not use if foil seal is broken or missing.
Ripley, MS 38663
2 fl. oz. (60 mL)
Depending on the reaction of the Rosel after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Rosel not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Rosel addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
|No side effects||4||80.0%|
|It has side effects||1||20.0%|
|Once in a day||4||50.0%|
|Twice in a day||2||25.0%|
|3 times in a day||2||25.0%|
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The information was verified by Dr. Rachana Salvi, MD Pharmacology