DRUGS & SUPPLEMENTS

Ratio-Citalopram

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Ratio-Citalopram uses


Pharmacological action

Ratio-Citalopram is an antidepressant. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin in the synapses of neurons of the CNS. Ratio-Citalopram lacks or has a very weak ability to bind to histamine, m-choline- and adrenoreceptors.

Pharmacokinetics

After oral administration Cmax of Ratio-Citalopram in plasma is achieved within 2-4 hours. The oral bioavailability is about 80%. Changes in plasma concentrations of Ratio-Citalopram are linear. Css in the plasma is established within 1-2 weeks of therapy.

Binding to plasma proteins is less than 80%.

In blood plasma Ratio-Citalopram is present mainly in unchanged form. This drug is metabolized by demethylation, deamination and oxidation.

T1/2 is 1.5 days.

Ratio-Citalopram is excreted by the kidneys and the bowel.

Why is Ratio-Citalopram prescribed?

Depression of various etiologies, panic disorder, obsessive-compulsive disorder.

Dosage and administration

Ratio-Citalopram is taken oral 1 time / day.

For adults depending on the evidence the initial dose of Ratio-Citalopram is 10-20 mg / day, if necessary, it may be increased up to 60 mg / day. For patients older than 65 years the dose is 20 mg / day, if necessary, it may be increase to 40 mg / day.

Ratio-Citalopram side effects, adverse reactions

Digestive system: frequently - dry mouth, nausea.

CNS: frequently - drowsiness, tremor, and in rare cases - seizures.

Cardiovascular system: possible slight decrease in heart rate.

Other: often - increased sweating.

Adverse reactions are usually transient and weakly expressed. They occur mainly during the first 2 weeks of treatment and usually decrease significantly with the improvement of the patient with depression.

Ratio-Citalopram contraindications

Hypersensitivity to Ratio-Citalopram; simultaneous taking MAO inhibitors.

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Using during pregnancy and breastfeeding

Safety of Ratio-Citalopram during pregnancy and lactation has not been established. Use of the drug is justified only in cases where the potential benefits of therapy to the mother justifies the potential risk to the fetus and child.

In experimental studies there was revealed no teratogenic effects and any effect of Ratio-Citalopram on reproduction and prenatal development of the fetus.

Special instructions

In patients with liver failure Ratio-Citalopram should be used in minimal doses.

At weak and moderate renal insufficiency it does not require correction of dosing regimen of Ratio-Citalopram Meliapharm, the information on the application in severe renal failure is absent.

During the treatment period with Ratio-Citalopram it is possibly a slight decrease in heart rate that has no clinical significance, however, patients with initially reduced heart rate Ratio-Citalopram may cause a more pronounced bradycardia.

The efficacy and safety of Ratio-Citalopram in children has not been established.

Ratio-Citalopram should not be used concurrently with MAO inhibitors.

Patients should be prescribed with care for Ratio-Citalopram in highest dose and high doses of cimetidine.

It should be borne in mind that patients with depression are often a decrease in ability to concentrate which can be exacerbated by the use of psychotropic drugs.

Ratio-Citalopram drug interactions

Simultaneous administration of Ratio-Citalopram with:

  • MAO inhibitors may develop a hypertensive crisis ;
  • cimetidine may moderate increase in Css of Ratio-Citalopram in plasmaThe inhibitory effect on CYP2D6 isoenzyme is expressed very poorly, so the interaction with drugs that affect the metabolism of this enzyme is minimal. But we can not exclude the decrease in the concentration of Ratio-Citalopram in plasma by increasing its metabolism by carbamazepine induction of liver enzymes in their simultaneous application.

    The effects of sumatriptan and other serotonergic medications can be amplified by Ratio-Citalopram in their simultaneous application.

    Ratio-Citalopram in case of emergency / overdose

    Symptoms: dizziness, sweating, nausea, vomiting, tremor, somnolence, sinus tachycardia. In more rare cases - amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, ECG changes.

    Treatment: gastric lavage and use of activated carbon. Maintaining an airway to ensure adequate ventilation and oxygenation. It is recommended careful observation and monitoring of vital functions. Due to the large volume of distribution of Ratio-Citalopram is unlikely efficiency such measures as forced diuresis, dialysis, hemoperfusion and exchange transfusion. There is no specific antidote.

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    Ratio-Citalopram pharmaceutical active ingredients containing related brand and generic drugs:

    infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Ratio-Citalopram available forms, composition, doses:

    infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Ratio-Citalopram destination | category:

    infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Ratio-Citalopram Anatomical Therapeutic Chemical codes:

    infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Ratio-Citalopram pharmaceutical companies:

    infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."CITALOPRAM HYDROBROMIDE SOLUTION [SILARX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "citalopram". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "citalopram". http://www.drugbank.ca/drugs/DB0021... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Ratio-Citalopram?

    Depending on the reaction of the Ratio-Citalopram after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ratio-Citalopram not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Ratio-Citalopram addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sDrugs.com conducted a study on Ratio-Citalopram, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ratio-Citalopram consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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    The information was verified by Dr. Arunabha Ray, MD Pharmacology

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