Puricos

Rating: 2.5 - 2 review(s)
What are the side effects you encounter while taking this medicine?
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Puricos uses


Pharmacological action

Puricos is a medication that violates the synthesis of uric acid. This drug is a structural analog of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing uric acid deposits and prevents their formation in tissues and kidney. Puricos increases urinary excretion of hypoxanthine and xanthine.

Pharmacokinetics

After oral administration Puricos is almost entirely absorbed from the gastrointestinal tract. This medication is metabolized to form alloxantin, which retains the ability to sufficiently long to inhibit xanthine oxidase. Cmax of Puricos in the blood plasma is reached after an average of 1.5 h, alloxantin - in 4.5 h after a single dose.

T1/2 of Puricos is 1-2 hours, alloxantin - about 15 hours. About 20% of the administered dose is excreted through the intestines and the rest by kidneys.

Why is Puricos prescribed?

Treatment and prevention of gout and hyperuricemia different genesis (including in conjunction with nephrolithiasis, renal failure, uric acid nephropathy). Recurrent mixed calcium oxalate kidney stones if hyperuricosuria. Increased production of urate due to enzyme disorders. Prevention of acute kidney disease in cytostatic and radiotherapy of tumors and leukemia, as well as full medical starvation.

Dosage and administration

The dosing regimen of Puricos is set individually under the control of concentrations of urate and uric acid in blood and urine. The ora ldose for adults is 100-900 mg / day depending on the severity of the disease. The frequency of admission is 2-4 times / day after a meal. For children under the age of 15 years - 10-20 mg / kg / day or 100-400 mg / day.

Maximum doses: if renal dysfunction - 100 mg / day. Increasing the dose is possible when on the background of the therapy remains an increased concentration of urate in the blood and urine.

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Puricos side effects, adverse reactions

Cardio-vascular system: in single cases - hypertension, bradycardia.

Digestive system: possible dyspepsia (including nausea, vomiting), diarrhea, transient increase of transaminases in blood serum; rarely - hepatitis, in single cases - stomatitis, liver function (transient increase of transaminases and alkaline phosphatase), steatorrhea.

CNS and peripheral nervous system: in single cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, seizures, neuropathy, visual impairment, cataracts, changes in the papilla of the optic nerve, disorders of taste sensations.

Hemopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function).

Urinary system: rarely - interstitial nephritis, in single cases - edema, uremia, hematuria.

Endocrine system: in single cases - sterility, impotence, gynecomastia, diabetes.

Metabolism: in single cases - hyperlipidemia.

Allergic reactions: skin rash, redness, itching; in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome.

Dermatological reactions: in rare cases - furunculosis, alopecia, discoloration of hair.

Puricos contraindications

Pronounced liver function and / or renal disease, pregnancy, lactation, hypersensitivity to Puricos.

Using during pregnancy and breastfeeding

Puricos is contraindicated during pregnancy and lactation.

Category effects on the fetus by FDA - C.

Special instructions

It is necessary to maintain urine output of at least 2 liters a day and a neutral or slightly alkaline reaction of urine, because it prevents the precipitation of urate and the formation of concretions. You should not begin therapy with Puricos until complete relief of acute attack of gout; during the first month of treatment is recommended prophylactic administration of NSAIDs or colchicine; in the case of an acute attack of gout during therapy was added to the anti-inflammatory drugs. If impaired renal and liver function (increased risk of side effects), the dose is decreased. First 6-8 weeks of treatment need regular liver function tests, and blood diseases require regular laboratory monitoring.

When a skin rash this drug is overturned, after the disappearance of the not copious rash there are possible a reappointment of the drug in its treatment of relapsed immediately terminate.

Use of azathioprine or 6-mercaptopurine on the background of Puricos permits a 4-fold reduction in their doses. This medication combined with a care with vidarabine.

Puricos drug interactions

With the simultaneous administration Puricos increases the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic agents.

Uricosuric medicines and salicylates in high doses reduce the activity of Puricos Biogaran.

With the simultaneous administration of Puricos and cytostatics there is often manifested myelotoxic effect than when applied separatively.

With the simultaneous administration of this drug and azathioprine or mercaptopurine it is observed accumulation of the latter in the body, because in connection with the activity of xanthine oxidase inhibition with Puricos necessary to biotransformation of drugs, slowing their metabolism and elimination.

Puricos in case of emergency / overdose

Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.

Treatment: forced diuresis, hemodialysis and peritoneal dialysis.

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Puricos pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Puricos available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Puricos destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Puricos Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Puricos pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."ALLOPURINOL TABLET [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ALLOPURINOL; LESINURAD: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "allopurinol". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Puricos?

Depending on the reaction of the Puricos after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Puricos not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Puricos addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Puricos, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Puricos consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Puricos useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Not useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Puricos is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Not expensive1
100.0%

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Puricos drug as prescribed by the doctor?

Few medications can be taken 3 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Puricos is mentioned below.
Visitors%
3 times in a day1
100.0%

Four visitors reported doses

What is the dose of Puricos drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 101-200mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
101-200mg2
50.0%
201-500mg2
50.0%

One visitor reported time for results

What is the time duration Puricos drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed > 3 month to notice the result from using Puricos drug. The time needed to show improvement in health condition after using the medicine Puricos need not be same for all the users. It varies based on other factors.
Visitors%
> 3 month1
100.0%

Visitor reported administration

No survey data has been collected yet

Eight visitors reported age

Visitors%
> 604
50.0%
46-603
37.5%
6-151
12.5%

Visitor reviews


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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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